Results 81 to 90 of about 3,055,415 (293)
Multistakeholder governance processes as production sites: enhanced cooperation "in the making"
Internet Policy Review, 2016 The paper combines actor-network theory and interpretative policy analysis to conceptualise multistakeholder arrangements in internet governance as production sites in which heterogeneous actors engage in dynamic processes of social ordering such as ...
Julia Pohle
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Enhanced Cooperation in the EU [PDF]
, 2019 Enhanced Cooperation in the EU Abstract Enhanced cooperation has been a widely discussed in the context of the further possible development of the European integration and its direction.
Černý, Filip
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Adaptace českého právního řádu na zřízení Úřadu evropského veřejného žalobce
Acta Universitatis Carolinae Iuridica, 2019 Council Regulation (EU) 2017/1939 of 12 October 2017 implementing enhanced cooperation on the establishment of the European Public Prosecutor’s Office (“the EPPO”) was published in the Official Journal of the European Union on 31 October 2017.
Jiří Pavlík
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
An Asia-Pacific Model of Development Cooperation [PDF]
Part One of the Osaka Action Agenda has clarified the implications of the basic political commitment to free and open trade and investment in the Bogor Declaration and has set out operational guiding principles and a well-developed strategy of ...
Foundation for Development Cooperation
core +2 more sources
Enhancing French Digital Preservation Cooperation.
, 2022 Since 2019, four groups have been created within the French association “Aristote”, including members of National Library & Archives and several Ministries. These four groups are working on these subjects: 1. Digital Formats knowledge: in all our institutions we must deal with many different formats, it was necessary to share our experience, help each ...
Grandcolas, Yannick +4 more
openaire +2 more sources