Results 61 to 70 of about 3,261,863 (291)

Book Review: Michael Baun and Dan Marek (eds.) The New Member States and the European Union. Foreign Policy and Europeanization [PDF]

Romanian Journal of European Affairs, 2014
A radical decision at the time, the 2004 enlargement constituted a critical juncture for the Central and Eastern European Countries. Although a great deal of literature has been written in regard to other aspects of Europeanization, the effects of EU ...
Adelin Dumitru
doaj  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Determinants of public cooperation in multiplex networks

New Journal of Physics, 2017
Synergies between evolutionary game theory and statistical physics have significantly improved our understanding of public cooperation in structured populations.
Federico Battiston, Matjaž Perc, Vito Latora   +2 more
doaj   +1 more source

Prospects for India-Serbia collaboration within the BRICS framework [PDF]

Srpska Politička Misao
This scholarly paper examines the prospects and strategic significance of cooperation between Serbia and India within the BRICS platform. Special attention is devoted to the economic dimension of cooperation, especially in international politics ...
Terzić Predrag, Anchev Stefan
doaj   +1 more source

Direct reciprocity in spatial populations enhances R-reciprocity as well as ST-reciprocity. [PDF]

PLoS ONE, 2013
As is well-known, spatial reciprocity plays an important role in facilitating the emergence of cooperative traits, and the effect of direct reciprocity is also obvious for explaining the cooperation dynamics.
Kohei Miyaji, Jun Tanimoto, Zhen Wang, Aya Hagishima, Naoki Ikegaya   +4 more
doaj   +1 more source

Enhanced Chelate Cooperativity in Polar Solvents

Journal of the American Chemical Society, 2017
Abstract High-throughput UV–vis titrations in combination with chemical double-mutant cycles (DMCs) have been used to study the competition of a polar solvent for formation of intramolecular H-bonds. Twenty-four different zinc porphyrin–pyridine complexes were investigated in mixtures of toluene and phenol. DMCs were used to determine
Stefan Henkel, Maria Cristina Misuraca, Yudi Ding, Maxime Guitet, Christopher A. Hunter   +4 more
openaire   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Impact of interaction style and degree on the evolution of cooperation on Barabási-Albert scale-free network. [PDF]

PLoS ONE, 2017
In this work, we study an evolutionary prisoner's dilemma game (PDG) on Barabási-Albert scale-free networks with limited player interactions, and explore the effect of interaction style and degree on cooperation.
Fengjie Xie, Jing Shi, Jun Lin
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source