Results 41 to 50 of about 3,261,863 (291)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

open access: yesFEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda   +2 more
wiley   +1 more source

Enhanced Cooperation and Free Movement. Territorial Aspects of ‘Harmonisation’

open access: yesPrzegląd Prawniczy Uniwersytetu im. Adama Mickiewicza, 2017
In this article we examine the notion of ‘harmonisation’ in its interplay with the application of provisions on the free movement of goods. Due to the introduction of the European unitary patent protection system, we are witnessing the first cases of ...
Miłosz Malaga, Anna Wilińska-Zelek
doaj   +1 more source

Individual and Cooperative Superexchange Enhancement in Cuprates

open access: yesJournal of Chemical Theory and Computation
It is now widely accepted that the antiferromagnetic coupling within high-temperature superconductors strongly exhibits a profound correlation with the upper limit of the superconducting transition temperature these materials can reach. Thus, accurately calculating the positive and negative mechanisms that influence magnetic coupling in specific ...
Jiang, Tonghuan   +3 more
openaire   +3 more sources

Enhanced Position Estimation via Node Cooperation [PDF]

open access: yes2010 IEEE International Conference on Communications, 2010
Two-way time-of-arrival (TW-ToA) is a widely used ranging protocol that can provide the distance between two devices without time synchronization. One drawback of the TW-ToA is poor positioning accuracy in the absence of a sufficient number of reference ranging devices.
Sahinoglu, Z., Gezici, Sinan
openaire   +3 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Enhanced cooperation under the Lisbon Treaty. [PDF]

open access: yes, 2011
Enhanced cooperation is often regarded as being a way out of EU decision-making deadlock and as a major possibility of proceeding with European integration in selected areas.
Groenendijk, Nico
core   +2 more sources

Enhancing Text Generation with Cooperative Training

open access: yes, 2023
Recently, there has been a surge in the use of generated data to enhance the performance of downstream models, largely due to the advancements in pre-trained language models. However, most prevailing methods trained generative and discriminative models in isolation, which left them unable to adapt to changes in each other.
Wu, Tong   +5 more
openaire   +2 more sources

Using cooperative learning to enhance critical reflection [PDF]

open access: yes2014 IEEE Frontiers in Education Conference (FIE) Proceedings, 2014
Over the past two decades, one of the key changes in Engineering curricula has been in the emphasis placed on the development of personal transferable skills. Employers also profess to seek these competencies when making recruiting decisions. Such skills include the ability to learn through collaboration and through meaningful critical reflection on ...
Meriel Huggard   +2 more
openaire   +3 more sources

Enhanced Cooperation in the EU [PDF]

open access: yes, 2019
Enhanced Cooperation in the EU Abstract Enhanced cooperation has been a widely discussed in the context of the further possible development of the European integration and its direction.
Černý, Filip
core  

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

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