Results 261 to 270 of about 1,265,582 (308)
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Strategies to Enhance Metabolic Stabilities
2019Macrocyclic peptides are a unique class of molecules that display a relatively constrained peptidic backbone as compared to their linear counterparts leading to the defined 3-D orientation of the constituent amino acids (pharmacophore). Although they are attractive candidates for lead discovery owing to the unique conformational features, their ...
Bhavesh, Khatri +2 more
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Metabolic engineering for enhanced oil in biomass
Progress in Lipid Research, 2019The world is hungry for energy. Plant oils in the form of triacylglycerol (TAG) are one of the most reduced storage forms of carbon found in nature and hence represent an excellent source of energy. The myriad of applications for plant oils range across foods, feeds, biofuels, and chemical feedstocks as a unique substitute for petroleum derivatives ...
Vanhercke, Thomas +8 more
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Enhanced thyroxine metabolism in hexachlorobenzene-intoxicated rats
Journal of Endocrinological Investigation, 1989The effect of hexachlorobenzene (HCB) (1 g/kg bw) administration for 4 weeks, on thyroxine (T4) and triiodothyronine (T3) metabolism was studied in Wistar rats. The effect on serum binding of T4 has also been studied. Animals were injected with a tracer dose of either labeled hormone and by examining serum L-125I-T4 and L-125-I-T3, kinetics of ...
D L, Kleiman de Pisarev +2 more
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Enhancement and Inhibition of Drug Metabolism
Annual Review of Pharmacology, 1971A large number of factors can alter rates of drug metabolism. This re view wiII discuss the enhancement and inhibition of drug metabolism. By enhancement is meant that increase in rate of in vitro drug metabolism ob served following the inclusion of other drugs or chemicals in the reaction mixture.
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Enhanced precision and efficiency in metabolic regulation: Compartmentalized metabolic engineering
Bioresource TechnologyMetabolic engineering has witnessed remarkable advancements, enabling successful large-scale, cost-effective and efficient production of numerous compounds. However, the predominant expression of heterologous genes in the cytoplasm poses limitations, such as low substrate concentration, metabolic competition and product toxicity.
Rubing Wang +5 more
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Signalling cascades integrating light-enhanced nitrate metabolism
Biochemical Journal, 2008In higher plants, light is crucial for regulation of nitrate uptake, translocation and assimilation into organic compounds. Part of this metabolism is tightly coupled to photosynthesis because the enzymes involved, nitrite reductase and glutamate synthase, are localized to the chloroplasts and receive reducing power from photosynthetic electron ...
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