Results 41 to 50 of about 350,297 (294)

Research Progress of Cancer-associated Fibroblasts in Lung Cancer

Chinese Journal of Lung Cancer, 2020
Tumor stroma plays key roles in promoting tumor recurrence and treatment resistance. Cancer-associated fibroblasts (CAFs) are one of the most abundant and key components in the stroma of lung cancer.
Chongbiao HUANG, Jie XU, Zengxun LI
doaj   +1 more source

Joint effects of polycyclic aromatic hydrocarbons, smoking, and XPC polymorphisms on damage in exon 2 of KRAS gene among young coke oven workers

Frontiers in Public Health, 2022
Genetic polymorphisms may contribute to individual susceptibility to DNA damage induced by environmental exposure. In this study, we evaluate the effects of co-exposure to PAHs, smoking and XPC polymorphisms, alone or combined, on damage in exons.
Siqin Chen, Xingyue Yin, Yuefeng He, Qinghua He, Xiaomei Li, Maosheng Yan, Suli Huang, Jiachun Lu, Binyao Yang   +8 more
doaj   +1 more source

Assessing the Value of Prehabilitation in Patients Undergoing Colorectal Surgery According to the Enhanced Recovery After Surgery (ERAS) Pathway for the Improvement of Postoperative Outcomes: Protocol for a Randomized Controlled Trial [PDF]

, 2017
A key element in the postoperative phase of the standardized Enhanced Recovery After Surgery (ERAS) treatment pathways is mobilization. Currently, there are no recommendations in the ERAS guidelines for preoperative physical activity. Patients undergoing
Breitenstein, Stefan, Gisi, David, Gloor, Severin, Greco, Nicola, Kerstan-Huber, Marta, Merki-Künzli, Cornelia, Misirlic, Merima, Mungo, Giuseppe, Raptis, Dimitri Aristotle, Switalla, Denise, Tschuor, Christoph, Wirz, Markus   +11 more
core   +1 more source

Enhanced Recovery after Surgery

, 2023
Enhanced recovery after surgery (ERAS) protocols are specialized perioperative care guidelines. The protocol was first published in 2005. Since then, it has been associated with improved perioperative outcomes. This multimodal peri-operative protocols standardize the perioperative care to minimize the surgical stress response and post-operative pain ...
Navin, Kumar,, Rohik, Anjum,, Dhiraj, Mallik,, Farhanul, Huda,, Bibek, Karki,, Somprakas, Basu,   +5 more
openaire   +2 more sources

Unveiling the heterogeneity and immunotherapy potency of tumor-associated neutrophils in the tumor microenvironment of gastric cancer

BMC Gastroenterology
Background The differentiation characteristics of neutrophils within the gastric cancer (GC) tumor microenvironment (TME) and their interactions with malignant gastric epithelial cells require further investigation. Furthermore, the therapeutic potential
Tong-tong Qi, Si-jiang Zhou, Zhu Yu, Yong Li, Jun-qiang Chen   +4 more
doaj   +1 more source

Cardiac magnetic resonance findings predict increased resource utilization in elective coronary artery bypass grafting [PDF]

, 2008
Morbidity following CABG (coronary artery bypass grafting) is difficult to predict and leads to increased healthcare costs. We hypothesized that pre-operative CMR (cardiac magnetic resonance) findings would predict resource utilization in elective CABG ...
Alfakih, American Heart Association, Anna F. Dominiczak, Baks, Bellenger, Berry, Berry, British Heart Foundation Heart Statistics, Christian Delles, Colin Berry, Eisenberg, Ferguson, Fieno, Geissler, Geoffrey A. Berg, Gibbons, Hein, Henry J. Dargie, Higgins, Higgins, Hombach, John E. Foster, Lassnigg, Lorenz, Lukas U. Zimmerli, Lund, Mark, Michalopoulos, Mosteller, Mounsey, Nathanson, Pell, Pennell, Roques, Rosamond, Schvartzman, Selvanayagam, Sievers, Simonetti, Tracey Steedman, Tu, Tu, Zimmerli   +42 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer

Frontiers in Pharmacology
BackgroundFrizzled class receptor 2 (FZD2), is a critical protein in the Wnt signaling pathway, which plays significant roles in various cancers. However, its role in cancer progression, prognosis, and diagnosis remains largely unexplored.
Sijiang Zhou, Sijiang Zhou, Sijiang Zhou, Sijiang Zhou, Da Li, Da Li, Da Li, Da Li, Chao Quan, Chao Quan, Zhu Yu, Zhu Yu, Zhu Yu, Yue Feng, Yue Feng, Yue Feng, Yue Feng, Shengyu Wang, Shengyu Wang, Shengyu Wang, Shengyu Wang, Yong Li, Yong Li, Yong Li, Yong Li, Tongtong Qi, Tongtong Qi, Tongtong Qi, Tongtong Qi, Junqiang Chen, Junqiang Chen, Junqiang Chen, Junqiang Chen   +32 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Systemic nutritional status and its dynamic changes as predictors of response to neoadjuvant immunotherapy in locally advanced MSS/pMMR colorectal cancer

Frontiers in Medicine
BackgroundPatients with locally advanced microsatellite-stable/mismatch repair–proficient (MSS/pMMR) colorectal cancer show heterogeneous responses to neoadjuvant immunotherapy, and effective predictive biomarkers are lacking. Systemic nutritional status
Haining Chen, Haining Chen, Zhiyuan Xia, Zhiyuan Xia, Yefu Shen, Yefu Shen, Xihua Xie, Xihua Xie, Ming Qiu, Ming Qiu, Minghui Lin, Minghui Lin, Shen Pang, Shen Pang, Dongchao Liu, Dongchao Liu, Wei Huang, Wei Huang, Sen Zhang, Sen Zhang   +19 more
doaj   +1 more source