Results 61 to 70 of about 344,740 (342)

Multidimensional collaboration; reflections on action research in a clinical context [PDF]

, 2011
This paper reflects on the challenges and benefits of multidimensional collaboration in an action research study to evaluate and improve preoperative education for patients awaiting colorectal surgery.
Cameron M., Carr W., Chelf J.H., Elliott J., Ely M., Fearon K.C.H., Fiona Poland, Hart E., Jane McCulloch, Kastanias P., Kevin Sargen, Kleinman A., Nicola J. Spalding, Penny Vicary, Robert G., Sheila Gregory, Spalding N., Spradley J.P., Stetler C.B., White P.F.   +19 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Up-regulation of NGEF via the BRAFV600E /ERK/AP1 pathway enhances invasion and migration abilities of BRAFV600E-mutant thyroid cancer

Biochemistry and Biophysics Reports
The BRAFV600E mutation is one of the most common genetic alterations in thyroid tumors, and intrinsic feedback mechanisms have limited the clinical application of BRAFV600E-specific inhibitors.
Zhao Fu, Ye Wang, Cong-Jun Wang, Zhu Yu, Jun-Qiang Chen   +4 more
doaj   +1 more source

Managing Prolonged Pain After Surgery: Examining the Role of Opioids. [PDF]

, 2018
A notable minority of patients experience persistent postsurgical pain and some of these patients consequently have prolonged exposure to opioids. Risk factors for prolonged opioid use after surgery include preoperative opioid use, anxiety, substance ...
Pozek, John-Paul J., Schwenk, Eric S., Viscusi, Eugene R.   +2 more
core   +1 more source

Cost-Benefit Analysis of the Implementation of an Enhanced Recovery Program in Liver Surgery. [PDF]

, 2016
BACKGROUND: Enhanced recovery after surgery (ERAS) programs have been shown to ease the postoperative recovery and improve clinical outcomes for various surgery types.
Blanc, C., Demartines, N., Griesser, A.C., Hübner, M., Joliat, G.R., Labgaa, I., Schäfer, M.   +6 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Factors influencing pathological complete response following neoadjuvant chemoimmunotherapy in locally advanced microsatellite stable colorectal cancer: a retrospective analysis

Frontiers in Medicine
ObjectiveThe purpose of this study is to identify and analyze the factors associated with achieving pathological complete response (pCR) in patients with locally advanced microsatellite stable (MSS) or proficient mismatch repair (pMMR) colorectal cancer ...
Mingxiang Liu, Mingxiang Liu, Qi Zhou, Qi Zhou, Bin Lan, Bin Lan, Jialiang Gan, Jialiang Gan, Sen Zhang, Sen Zhang   +9 more
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

The role of nursing in enhanced recovery after surgery programs in accordance with spine surgery: A mini review

Journal of Integrative Nursing, 2022
Spine surgery is typically having a relationship to high degrees of pain and immobility. It is a known fact that the implementation of an enhanced recovery after surgery (ERAS) approach has led to a paradigm shift in various surgical specialties.
Qing-Qing Hou, Xue Luo, Hong-Mian Li, Ying Hou, Zhi Zhang   +4 more
doaj   +1 more source