Results 11 to 20 of about 124,245 (199)
Cytogenetics laboratory tests are among the most important procedures for the diagnosis of genetic diseases, especially in the area of hematological malignancies.
Yahya Bokhari +10 more
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An amendment to this paper has been published and can be accessed via the original article.
Madelin R. Siedler +14 more
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Achievement and Enhancement [PDF]
AbstractWe engage with the nature and the value of achievement through a critical examination of an argument according to which biomedical “enhancement” of our capacities is impermissible because enhancing ourselves in this way would threaten our achievements. We call this the argument against enhancement from achievement.
Lisa Forsberg, Anthony Skelton
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Enhancers are short noncoding segments of DNA (100-1000 bp) that control the temporal and spatial activity of genes in an orientation-independent manner. They can be separated from their target genes by large distances and are thus known as distal regulatory elements.
Snetkova, Valentina, Skok, Jane A
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Typical Enhancers, Super-Enhancers, and Cancers
Non-coding segments of the human genome are enriched in cis-regulatory modules that constitute functional elements, such as transcriptional enhancers and Super-enhancers. A hallmark of cancer pathogenesis is the dramatic dysregulation of the “archetype” gene expression profiles of normal human cells.
Marianna A. Koutsi +6 more
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AbstractTranscription of eukaryotic genes is an exceedingly sophisticated and complicated process, orchestrated by layers of control mechanisms involving a myriad of transcription factors and DNA control sequences, with both groups subject to multiple modifications.
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Transcriptional control by enhancers and enhancer RNAs [PDF]
The regulation of gene expression is a fundamental cellular process and its misregulation is a key component of disease. Enhancers are one of the most salient regulatory elements in the genome and help orchestrate proper spatiotemporal gene expression during development, in homeostasis, and in response to signaling.
Michael W. Lewis +2 more
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From enhanced coinduction towards enhanced induction [PDF]
There exist a rich and well-developed theory of enhancements of the coinduction proof method, widely used on behavioural relations such as bisimilarity. We study how to develop an analogous theory for inductive behaviour relations, i.e., relations defined from inductive observables.
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Enhancers, enhancers – from their discovery to today’s universe of transcription enhancers [PDF]
AbstractTranscriptional enhancers are short (200–1500 base pairs) DNA segments that are able to dramatically boost transcription from the promoter of a target gene. Originally discovered in simian virus 40 (SV40), a small DNA virus, transcription enhancers were soon also found in immunoglobulin genes and other cellular genes as key determinants of cell-
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Accuracy Assessment and Correction of SRTM DEM Using ICESat/GLAS Data under Data Coregistration
Shuttle Radar Topography Mission (SRTM) digital elevation model (DEM) inherently suffers from various errors. Many previous works employed Geoscience Laser Altimeter System onboard the Ice, Cloud, and land Elevation Satellite (ICESat/GLAS) data to assess
Chuanfa Chen, Shuai Yang, Yanyan Li
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