Results 1 to 10 of about 88,833 (257)
Characterizing Genetic Regulatory Elements in Ovine Tissues
Frontiers in Genetics, 2021 The Ovine Functional Annotation of Animal Genomes (FAANG) project, part of the broader livestock species FAANG initiative, aims to identify and characterize gene regulatory elements in domestic sheep.
Kimberly M. Davenport +14 more
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Establishment and function of chromatin modification at enhancers [PDF]
Open Biology, 2020 How a single genome can give rise to distinct cell types remains a fundamental question in biology. Mammals are able to specify and maintain hundreds of cell fates by selectively activating unique subsets of their genome.
Amanuel Tafessu, Laura A. Banaszynski
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F1000Research, 2017 The regulation of gene transcription in higher eukaryotes is accomplished through the involvement of transcription start site (TSS)-proximal (promoters) and -distal (enhancers) regulatory elements.
David Santiago-Algarra +4 more
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Multimodal single cell analysis infers widespread enhancer co-activity in a lymphoblastoid cell line
Communications Biology, 2023 Non-coding regulatory elements such as enhancers are key in controlling the cell-type specificity and spatio-temporal expression of genes. To drive stable and precise gene transcription robust to genetic variation and environmental stress, genes are ...
Chaymae Ziyani +2 more
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Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity
eLife, 2019 Enhancers are important regulatory elements that can control gene activity across vast genetic distances. However, the underlying nature of this regulation remains obscured because it has been difficult to observe in living cells.
Jeffrey M Alexander +8 more
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PLoS Computational Biology, 2022 Genetic risk for complex traits is strongly enriched in non-coding genomic regions involved in gene regulation, especially enhancers. However, we lack adequate tools to connect the characteristics of these disruptions to genetic risk.
Alex M Casella +2 more
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Enhancer/gene relationships: Need for more reliable genome-wide reference sets
Frontiers in Bioinformatics, 2023 Differences in cells’ functions arise from differential activity of regulatory elements, including enhancers. Enhancers are cis-regulatory elements that cooperate with promoters through transcription factors to activate the expression of one or several ...
Tristan Hoellinger +9 more
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eLife, 2023 Cancer is driven by both genetic and epigenetic changes that impact on gene expression profiles and the resulting tumourigenic phenotype. Enhancers are transcriptional regulatory elements that are key to our understanding of how this rewiring of gene ...
Ibrahim Ahmed +6 more
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Breast Cancer Research, 2021 Background Approximately 5–10% of HER2-positive breast cancers can be defined by low expression of the Ste20-like kinase, SLK, and high expression of SOX10.
Khalid N. Al-Zahrani +5 more
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Genome Medicine, 2021 Background Enhancers are distal cis-regulatory elements required for cell-specific gene expression and cell fate determination. In cancer, enhancer variation has been proposed as a major cause of inter-patient heterogeneity—however, most predicted ...
Taotao Sheng +23 more
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