Results 1 to 10 of about 4,995,766 (296)
Genetic variations within human gained enhancer elements affect human brain sulcal morphology [PDF]
NeuroImage, 2023 The expansion of the cerebral cortex is one of the most distinctive changes in the evolution of the human brain. Cortical expansion and related increases in cortical folding may have contributed to emergence of our capacities for high-order cognitive ...
Herve Lemaitre +7 more
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PLoS Computational Biology, 2022 Genetic risk for complex traits is strongly enriched in non-coding genomic regions involved in gene regulation, especially enhancers. However, we lack adequate tools to connect the characteristics of these disruptions to genetic risk.
Alex M Casella +2 more
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Frontiers in Genetics, 2022 A major goal of genetics research is to elucidate mechanisms explaining how genetic variation contributes to phenotypic variation. The genetic variants identified in genome-wide association studies (GWASs) generally explain only a small proportion of ...
Mariana Saint Just Ribeiro +6 more
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Parallel functional testing identifies enhancers active in early postnatal mouse brain
eLife, 2021 Enhancers are cis-regulatory elements that play critical regulatory roles in modulating developmental transcription programs and driving cell-type-specific and context-dependent gene expression in the brain. The development of massively parallel reporter
Jason T Lambert +19 more
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Characterization of transcriptional enhancers in the chicken genome using CRISPR-mediated activation
Frontiers in Genome Editing, 2023 DNA regulatory elements intricately control when, where, and how genes are activated. Therefore, understanding the function of these elements could unveil the complexity of the genetic regulation network.
Jeong Hoon Han +3 more
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iScience, 2022 Summary: Regulation of chromatin accessibility is critical for cell fate decisions. Chromatin structure responds to extrinsic environments rapidly. The traditional adult stem cell isolation approach requires tissue dissociation, which triggers stem cell ...
Anqi Dong +6 more
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Regulation of inflammation in diabetes: From genetics to epigenomics evidence
Molecular Metabolism, 2020 Background: Diabetes is one of the greatest public health challenges worldwide, and we still lack complementary approaches to significantly enhance the efficacy of preventive and therapeutic approaches.
Marc Diedisheim +5 more
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Nature Communications, 2021 Genetic elements that control inflammatory gene expression are not fully elucidated. Here the authors conduct a multi-species analysis of chromatin landscape and NF-κB binding in response to the proinflammatory cytokine TNFα, finding that conserved NF-κB
Azad Alizada +11 more
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Establishment and function of chromatin modification at enhancers [PDF]
Open Biology, 2020 How a single genome can give rise to distinct cell types remains a fundamental question in biology. Mammals are able to specify and maintain hundreds of cell fates by selectively activating unique subsets of their genome.
Amanuel Tafessu, Laura A. Banaszynski
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Characterizing Genetic Regulatory Elements in Ovine Tissues
Frontiers in Genetics, 2021 The Ovine Functional Annotation of Animal Genomes (FAANG) project, part of the broader livestock species FAANG initiative, aims to identify and characterize gene regulatory elements in domestic sheep.
Kimberly M. Davenport +14 more
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