Results 1 to 10 of about 127,657 (311)
Biology Open, 2022 The expression of a large number of genes is regulated by regulatory elements that are located far away from their promoters. Identifying which gene is the target of a specific regulatory element or is affected by a non-coding mutation is often ...
Ellora Hui Zhen Chua +2 more
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Characterization of enhancer fragments in Drosophila robo2
Fly, 2022 Receptor proteins of the Roundabout (Robo) family regulate axon guidance decisions during nervous system development. Among the three Drosophila robo family genes (robo1, robo2 and robo3), robo2 displays a dynamic expression pattern and regulates ...
Gina Hauptman +3 more
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Building a Mammalian Retina: An Eye on Chromatin Structure
Frontiers in Genetics, 2021 Regulation of gene expression by chromatin structure has been under intensive investigation, establishing nuclear organization and genome architecture as a potent and effective means of regulating developmental processes.
Marwa Daghsni +3 more
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Characterization of sequence determinants of enhancer function using natural genetic variation
eLife, 2022 Sequence variation in enhancers that control cell-type-specific gene transcription contributes significantly to phenotypic variation within human populations.
Marty G Yang +4 more
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Insights into the roles and driving forces of CCT3 in human tumors
Frontiers in Pharmacology, 2022 CCT3 played a key role in many cancers. This study aimed to further explore the characteristics of CCT3 from a pan-cancer perspective and reveal the driving forces for CCT3.
Jingang Ma +9 more
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Frontiers in Cell and Developmental Biology, 2022 Epigenetic regulation is integral in orchestrating the spatiotemporal regulation of gene expression which underlies tissue development. The emergence of new tools to assess genome-wide epigenetic modifications has enabled significant advances in the ...
Virginia Panara +3 more
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eLife, 2020 Genome-wide association studies for non-syndromic orofacial clefting (OFC) have identified single nucleotide polymorphisms (SNPs) at loci where the presumed risk-relevant gene is expressed in oral periderm.
Huan Liu +12 more
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Cell Genomics, 2022 Summary: Repeat elements can be dysregulated at a genome-wide scale in human diseases. For example, in Ewing sarcoma, hundreds of inert GGAA repeats can be converted into active enhancers when bound by EWS-FLI1.
Y. Esther Tak +16 more
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Enhancers in polymeric nonviral gene delivery systems
View, 2021 Gene therapy is a promising therapeutic tool for cancers and inherited diseases. For successful gene therapy, gene delivery systems must be designed reasonably to allow DNA or other nuclear acids to be taken up by the cancer cells and then transported to
Zhiyu Yang +3 more
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Biology and Life Sciences Forum, 2022 Wheat flour (WF) was replaced with potato flour (PF) at 10%, 20% and 30% (w/w) in combination with enhancers xanthan gum (XG) and wheat gluten (WG). The flour quality, rheological properties and noodle quality were analyzed.
Luis Olivera-Montenegro +5 more
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