Results 21 to 30 of about 141,342 (308)
Mapping the Shh long-range regulatory domain [PDF]
, 2014 Coordinated gene expression controlled by long-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and layers of control mechanisms.
Hill, Robert E +3 more
core +1 more source
Cell Reports, 2016 DNA methylation is one of a number of modes of epigenetic gene regulation. Here, we profile the DNA methylome, transcriptome, and global occupancy of histone modifications (H3K4me1, H3K4me3, H3K27me3, and H3K27ac) in a series of mouse embryonic stem ...
Andrew D. King +7 more
doaj +1 more source
Kinetic sculpting of the seven stripes of the Drosophila even-skipped gene
eLife, 2020 We used live imaging to visualize the transcriptional dynamics of the Drosophila melanogaster even-skipped gene at single-cell and high-temporal resolution as its seven stripe expression pattern forms, and developed tools to characterize and visualize ...
Augusto Berrocal +3 more
doaj +1 more source
The Causes and Consequences of Spatial Organization of the Genome in Regulation of Gene Expression
Frontiers in Immunology, 2021 Regulation of gene expression in time, space and quantity is orchestrated by the functional interplay of cis-acting elements and trans-acting factors.
Marios Agelopoulos +2 more
doaj +1 more source
Transcriptional control by enhancers and enhancer RNAs [PDF]
Transcription, 2019 The regulation of gene expression is a fundamental cellular process and its misregulation is a key component of disease. Enhancers are one of the most salient regulatory elements in the genome and help orchestrate proper spatiotemporal gene expression during development, in homeostasis, and in response to signaling.
Michael W. Lewis +2 more
openaire +2 more sources
Epigenetics, 2022 Illumina Infinium DNA Methylation (5mC) arrays are a popular technology for low-cost, high-throughput, genome-scale measurement of 5mC distribution, especially in cancer and other complex diseases. After the success of its HumanMethylation450 array (450k)
Martin Bizet +6 more
doaj +1 more source
Information, 2023 Enhancers are short DNA segments (50–1500 bp) that effectively activate gene transcription when transcription factors (TFs) are present. There is a correlation between the genetic differences in enhancers and numerous human disorders including cancer and
Mehwish Gill +3 more
doaj +1 more source
The CRISP(Y) Future of Pediatric Soft Tissue Sarcomas
Frontiers in Chemistry, 2020 The RNA-guided clustered regularly interspaced palindromic repeats (CRISPR)/associated nuclease 9 (Cas9)-based genome editing technology has increasingly become a recognized method for translational research.
Silvia Pomella, Rossella Rota
doaj +1 more source
Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers
Epigenetics, 2022 Genome-wide association studies (GWAS) have identified SNPs linked with lung cancer risk. Our aim was to discover the genes, non-coding RNAs, and regulatory elements within GWAS-identified risk regions that are deregulated in non-small cell lung ...
Marina Laplana +14 more
doaj +1 more source
From enhanced coinduction towards enhanced induction [PDF]
Proceedings of the ACM on Programming Languages, 2022 There exist a rich and well-developed theory of enhancements of the coinduction proof method, widely used on behavioural relations such as bisimilarity. We study how to develop an analogous theory for inductive behaviour relations, i.e., relations defined from inductive observables.
openaire +4 more sources