Results 21 to 30 of about 127,657 (311)
WIREs Developmental Biology, 2012 AbstractTranscription of eukaryotic genes is an exceedingly sophisticated and complicated process, orchestrated by layers of control mechanisms involving a myriad of transcription factors and DNA control sequences, with both groups subject to multiple modifications.
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Transcriptional control by enhancers and enhancer RNAs [PDF]
Transcription, 2019 The regulation of gene expression is a fundamental cellular process and its misregulation is a key component of disease. Enhancers are one of the most salient regulatory elements in the genome and help orchestrate proper spatiotemporal gene expression during development, in homeostasis, and in response to signaling.
Michael W. Lewis +2 more
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Computational prediction of splicing regulatory elements shared by Tetrapoda organisms [PDF]
, 2009 Background: auxiliary splicing sequences play an important role in ensuring accurate and efficient splicing by promoting or repressing recognition of authentic splice sites.
Churbanov, Alexander +8 more
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Cell Reports, 2016 DNA methylation is one of a number of modes of epigenetic gene regulation. Here, we profile the DNA methylome, transcriptome, and global occupancy of histone modifications (H3K4me1, H3K4me3, H3K27me3, and H3K27ac) in a series of mouse embryonic stem ...
Andrew D. King +7 more
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Kinetic sculpting of the seven stripes of the Drosophila even-skipped gene
eLife, 2020 We used live imaging to visualize the transcriptional dynamics of the Drosophila melanogaster even-skipped gene at single-cell and high-temporal resolution as its seven stripe expression pattern forms, and developed tools to characterize and visualize ...
Augusto Berrocal +3 more
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The Causes and Consequences of Spatial Organization of the Genome in Regulation of Gene Expression
Frontiers in Immunology, 2021 Regulation of gene expression in time, space and quantity is orchestrated by the functional interplay of cis-acting elements and trans-acting factors.
Marios Agelopoulos +2 more
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Epigenetics, 2022 Illumina Infinium DNA Methylation (5mC) arrays are a popular technology for low-cost, high-throughput, genome-scale measurement of 5mC distribution, especially in cancer and other complex diseases. After the success of its HumanMethylation450 array (450k)
Martin Bizet +6 more
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Information, 2023 Enhancers are short DNA segments (50–1500 bp) that effectively activate gene transcription when transcription factors (TFs) are present. There is a correlation between the genetic differences in enhancers and numerous human disorders including cancer and
Mehwish Gill +3 more
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H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation. [PDF]
, 2013 SummaryChromatin modifications have been implicated in the self-renewal and differentiation of embryonic stem cells (ESCs). However, the function of histone variant H2A.Z in ESCs remains unclear.
Northrup, D. +18 more
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The CRISP(Y) Future of Pediatric Soft Tissue Sarcomas
Frontiers in Chemistry, 2020 The RNA-guided clustered regularly interspaced palindromic repeats (CRISPR)/associated nuclease 9 (Cas9)-based genome editing technology has increasingly become a recognized method for translational research.
Silvia Pomella, Rossella Rota
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