Results 11 to 20 of about 141,342 (308)
Typical Enhancers, Super-Enhancers, and Cancers
Cancers, 2022 Non-coding segments of the human genome are enriched in cis-regulatory modules that constitute functional elements, such as transcriptional enhancers and Super-enhancers. A hallmark of cancer pathogenesis is the dramatic dysregulation of the “archetype” gene expression profiles of normal human cells.
Marianna A. Koutsi +6 more
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Enhancers, enhancers – from their discovery to today’s universe of transcription enhancers [PDF]
Biological Chemistry, 2015 AbstractTranscriptional enhancers are short (200–1500 base pairs) DNA segments that are able to dramatically boost transcription from the promoter of a target gene. Originally discovered in simian virus 40 (SV40), a small DNA virus, transcription enhancers were soon also found in immunoglobulin genes and other cellular genes as key determinants of cell-
Schaffner, Walter
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Journal of Bioethical Inquiry, 2022 AbstractTransgender healthcare faces a dilemma. On the one hand, access to certain medical interventions, including hormone treatments or surgeries, where desired, may be beneficial or even vital for some gender dysphoric trans people. But on the other hand, access to medical interventions typically requires a diagnosis, which, in turn, seems to imply ...
Hazem Zohny +2 more
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Enhancing Photorealism Enhancement
IEEE Transactions on Pattern Analysis and Machine Intelligence, 2023 Code and data available at https://github.com/intel-isl/PhotorealismEnhancement Video available at https://youtu.be ...
Stephan R. Richter +2 more
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Unique activities of overlapping developmental enhancers [PDF]
, 2023 Enhancers are non-coding elements that activate gene expression in precise spatial and temporal patterns, controlling the complex, tissue-specific gene expression programs underpinning the development and homeostasis of complex organisms.
Uttley, Kirsty
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Achievement and Enhancement [PDF]
Canadian Journal of Philosophy, 2019 AbstractWe engage with the nature and the value of achievement through a critical examination of an argument according to which biomedical “enhancement” of our capacities is impermissible because enhancing ourselves in this way would threaten our achievements. We call this the argument against enhancement from achievement.
Lisa Forsberg, Anthony Skelton
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Autonomy and Enhancement [PDF]
Neuroethics, 2013 Some have objected to human enhancement on the grounds that it violates the autonomy of the enhanced. These objections, however, overlook the interesting possibility that autonomy itself could be enhanced. How, exactly, to enhance autonomy is a difficult problem due to the numerous and diverse accounts of autonomy in the literature.
Schaefer G.O., Kahane G., Savulescu J.
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Epigenomics, 2018 Enhancers are short noncoding segments of DNA (100-1000 bp) that control the temporal and spatial activity of genes in an orientation-independent manner. They can be separated from their target genes by large distances and are thus known as distal regulatory elements.
Snetkova, Valentina, Skok, Jane A
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WIREs Developmental Biology, 2012 AbstractTranscription of eukaryotic genes is an exceedingly sophisticated and complicated process, orchestrated by layers of control mechanisms involving a myriad of transcription factors and DNA control sequences, with both groups subject to multiple modifications.
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Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome. [PDF]
, 2015 Enhancers can regulate the transcription of genes over long genomic distances. This is thought to lead to selection against genomic rearrangements within such regions that may disrupt this functional linkage.
Rinkwitz, S +72 more
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