Results 1 to 10 of about 466,642 (309)

The SPARC complex defines RNAPII promoters in Trypanosoma brucei

open access: yeseLife, 2022
Kinetoplastids are a highly divergent lineage of eukaryotes with unusual mechanisms for regulating gene expression. We previously surveyed 65 putative chromatin factors in the kinetoplastid Trypanosoma brucei.
Desislava P Staneva   +8 more
doaj   +1 more source

Comprehensive bioinformatic analysis reveals oncogenic role of H2A.Z isoforms in cervical cancer progression [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2021
Objective(s): Cervical cancer ranks as the fourth most common neoplasia in women worldwide in which epigenetic alterations play an important role. Several studies have reported pro-oncogenic role of the histone variant H2A.Z in different types of cancer;
Eric Salmerón-Bárcenas   +6 more
doaj   +1 more source

A Novel Small NPC1 Promoter Enhances AAV-Mediated Gene Therapy in Mouse Models of Niemann–Pick Type C1 Disease

open access: yesCells, 2023
Niemann–Pick disease type C1 (NP-C) is a prematurely lethal genetic lysosomal storage disorder with neurological and visceral pathology resulting from mutations in the NPC1 gene encoding the lysosomal transmembrane protein NPC1.
Michael Paul Hughes   +8 more
doaj   +1 more source

Examination of Genetic Control Elements in the Phototrophic Firmicute Heliomicrobium modesticaldum

open access: yesMicroorganisms, 2022
Heliomicrobium modesticaldum has been used as a model organism for the Heliobacteria, the only phototrophic family in the Firmicutes. It is a moderately thermophilic anoxygenic phototrophic bacterium that is capable of fermentative growth in the dark ...
Alexandria M. Layton, Kevin E. Redding
doaj   +1 more source

Genome-Wide Atlas of Promoter Expression Reveals Contribution of Transcribed Regulatory Elements to Genetic Control of Disuse-Mediated Atrophy of Skeletal Muscle

open access: yesBiology, 2021
The prevention of muscle atrophy carries with it clinical significance for the control of increased morbidity and mortality following physical inactivity.
Sergey S. Pintus   +12 more
doaj   +1 more source

The role of noncoding genetic variants in cardiomyopathy

open access: yesFrontiers in Cardiovascular Medicine, 2023
Cardiomyopathies remain one of the leading causes of morbidity and mortality worldwide. Environmental risk factors and genetic predisposition account for most cardiomyopathy cases.
Myo Htet   +7 more
doaj   +1 more source

Genomic and transcriptomic analysis of Ligilactobacillus salivarius IBB3154—in search of new promoters for vaccine construction

open access: yesMicrobiology Spectrum, 2023
Transcriptomic analysis of the genome sequenced Ligilactobacillus salivarius strain IBB3154 grown at two different temperatures (37°C vs 42°C) identified differentially expressed genes involved in metabolic pathways, osmoregulation, and surface protein ...
Patrycja Kobierecka   +6 more
doaj   +1 more source

Differential Functions of Individual Transcription Factor Binding Sites in the Tandem Repeats Found in Clinically Relevant cyp51A Promoters in Aspergillus fumigatus

open access: yesmBio, 2022
Aspergillus fumigatus is the major filamentous fungal pathogen in humans. The gold standard treatment of A. fumigatus is based on azole drug use, but the appearance of azole-resistant isolates is increasing at an alarming rate.
Sanjoy Paul   +3 more
doaj   +1 more source

CHOOSING EQUITY AS A SOURCE OF FINANCE: PERCEPTION OF SME PROMOTERS

open access: yesCopernican Journal of Finance & Accounting, 2020
This paper tries to understand the perception of SMEs’ promoters in choosing equity as one of their sources of finance. To explore reasons the research has been done in five phases which included: a literature review, offer document objectives, ratio ...
Ansita Aggarwal, Satya Ranjan Acharya
doaj   +1 more source

Mix and Match: Promoters and Terminators for Tuning Gene Expression in the Methylotrophic Yeast Ogataea polymorpha

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
The yeast Ogataea polymorpha is an upcoming host for bio-manufacturing due to its unique physiological properties, including its broad substrate spectrum, and particularly its ability to utilize methanol as the sole carbon and energy source.
Katrin Wefelmeier   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy