Results 41 to 50 of about 424,435 (217)

Adherence to Antiretroviral Therapy and Its Related Factors among HIV-Infected Patients: A Mixed-Methods Study [PDF]

Journal of Midwifery & Reproductive Health
Background & aim: High levels of adherence to treatment among HIV patients as one of the sexually transmitted diseases (STD) are essential for promoting viral suppression and preventing drug resistance, but little is known about the factors that ...
Amin Ghanbari, Maryam Ordibeheshti Khiaban, Nazila Sattari, Azita Fathnezhad Kazemi   +3 more
doaj   +1 more source

Mix and Match: Promoters and Terminators for Tuning Gene Expression in the Methylotrophic Yeast Ogataea polymorpha

Frontiers in Bioengineering and Biotechnology, 2022
The yeast Ogataea polymorpha is an upcoming host for bio-manufacturing due to its unique physiological properties, including its broad substrate spectrum, and particularly its ability to utilize methanol as the sole carbon and energy source.
Katrin Wefelmeier, Birgitta E. Ebert, Lars M. Blank, Simone Schmitz   +3 more
doaj   +1 more source

Adapting a health facility HIV stigma-reduction participatory training intervention to address drug use stigma in HIV care and treatment clinics in Dar es Salaam, Tanzania

Harm Reduction Journal
Background HIV prevalence among people who use drugs (PWUD) in Tanzania is 4–7 times higher than in the general population, underscoring an urgent need to increase HIV testing and treatment among PWUD.
Linda B. Mlunde, Khalida Saalim, Jessie K. Mbwambo, Pfiriael Kiwia, Elizabeth Fitch, Willbrord Manyama, Isack Rugemalila, Sue Clay, Barrot H. Lambdin, Rachel D. Stelmach, Carla Bann, Laura Nyblade   +11 more
doaj   +1 more source

Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons

eLife, 2017
The monogenic and monoallelic expression of only one out of >1000 mouse olfactory receptor (ORs) genes requires the formation of large heterochromatic chromatin domains that sequester the OR gene clusters.
Kevin Monahan, Ira Schieren, Jonah Cheung, Alice Mumbey-Wafula, Edwin S Monuki, Stavros Lomvardas   +5 more
doaj   +1 more source

Developing a minimally invasive gene therapy for multiple sclerosis

Molecular Therapy: Methods & Clinical Development
Multiple sclerosis (MS) is a neurological disease characterized by demyelinating lesions in the CNS. This study investigated whether a minimally invasive adeno-associated virus (AAV) vector (AAV.PHP.eB) can direct transgene expression in CNS cell types ...
Paul J.H. Nijhuis, Maurits Romijn, Roy Honing, Giselle van Zon, Inge Huitinga, Fred de Winter, Joost Verhaagen   +6 more
doaj   +1 more source

Reverse protection assay: a tool to analyze transcriptional rates from individual promoters

Plant Methods, 2011
Transcriptional activity of entire genes in chloroplasts is usually assayed by run-on analyses. To determine not only the overall intensity of transcription of a gene, but also the rate of transcription from a particular promoter, we created the Reverse ...
Zubo Yan O, Kusnetsov Victor V, Börner Thomas, Liere Karsten   +3 more
doaj   +1 more source

Phylogenetic comparison of the known Chlamydia trachomatis σ66 promoters across to Chlamydia pneumoniae and Chlamydia caviae identifies seven poorly conserved promoters

, 2008
We used four different phylogenetic footprinting programs and the six chlamydial species with publicly available whole genome sequences to analyze the 12 known σ66 promoters of Chlamydia trachomatis that phylogenetically footprinted negative in our ...
Mathews, Sarah A., Timms, Peter, Grech, Brian J., Mathews, S, Grech, B   +4 more
core   +1 more source

Identification of Leaf Promoters for Use in Transgenic Wheat [PDF]

, 2018
Wheat yields have plateaued in recent years and given the growing global population there is a pressing need to develop higher yielding varieties to meet future demand.
Parry, Martin, Martin Parry, Parry, M. A. J., Alotaibi, Saqer S, Alotaibi, Saqer S., Raines, Christine A, Raines, C. A., Parry, Martin A.J., Sparks, Caroline A, Caroline Sparks, Andrew Simkin, Saqer S. Alotaibi, Simkin, A. J., Raines, Christine, Simkin, Andrew J, Sparks, Caroline A., Caroline A. Sparks, Andrew J. Simkin, Christine Raines, Raines, Christine A., Alotaibi, Saqer, Christine A. Raines, Sparks, Caroline, Simkin, Andrew, Parry, Martin AJ, Alotaibi, S. S., Saqer Alotaibi, Martin A. J. Parry, Sparks, C. A., Simkin, Andrew J.   +29 more
core   +1 more source

Recent Developments in Heterologous Expression of Cellulases Using the Pichia pastoris Expression System: A Comprehensive Literature Review

Applied Microbiology
Cellulosic biomass is considered an important and sustainable source of renewable energy, which needs a complex mixture of different enzymes for its degradation. After amylase, cellulases are the second most important enzymes, gain more importance due to
Nazish Muzaffar, Abdur Raziq, Muhammad Waseem Khan, Niaz Muhammad Khan, Bushra Shahid, Anbareen Gul, Hayat Ullah   +6 more
doaj   +1 more source

Promoting Adipose Specificity: The Adiponectin Promoter [PDF]

Endocrinology, 2010
In the modern obesogenic environment, obesity, insulin resistance and type 2 diabetes mellitus are becoming a global epidemic. At the organismal level, obesity is causally linked to the metabolic dysfunction of energy balance and homeostasis in the adipose tissue (reviewed in Refs. 1–3).
openaire   +2 more sources