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Niemann–Pick disease type C1 (NP-C) is a prematurely lethal genetic lysosomal storage disorder with neurological and visceral pathology resulting from mutations in the NPC1 gene encoding the lysosomal transmembrane protein NPC1.
Michael Paul Hughes +8 more
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Functional analysis of human and chimpanzee promoters [PDF]
Background: It has long been argued that changes in gene expression may provide an additional and crucial perspective on the evolutionary differences between humans and chimpanzees.
Philipp Khaitovich +21 more
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Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq
R-loops are features of chromatin consisting of a strand of DNA hybridized to RNA, as well as the expelled complementary DNA strand. R-loops are enriched at promoters where they have recently been shown to have important roles in modifying gene ...
Jason G Dumelie, Samie R Jaffrey
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Ownership Structure and the Risk: Analysis of Indian Firms
Considering the positive relationship between ownership and firm performance in the corporate finance literature, the paper aims to investigate the effect of ownership structure on the risk associated with the firm.
Kumari Ranjita, Kumar Nishant
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Examination of Genetic Control Elements in the Phototrophic Firmicute Heliomicrobium modesticaldum
Heliomicrobium modesticaldum has been used as a model organism for the Heliobacteria, the only phototrophic family in the Firmicutes. It is a moderately thermophilic anoxygenic phototrophic bacterium that is capable of fermentative growth in the dark ...
Alexandria M. Layton, Kevin E. Redding
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Promoting human promoters [PDF]
Mol Syst Biol. 2: 2006.0030 The effect of transcription factors on human gene expression can now be quantified owing to a new computational approach. The method was successfully applied to the cases of the cell cycle program, and for liver‐specific gene expression. Transcriptional regulation of gene expression plays a major role in the acquisition of
Furman, Itay, Pilpel, Yitzhak
openaire +1 more source
The prevention of muscle atrophy carries with it clinical significance for the control of increased morbidity and mortality following physical inactivity.
Sergey S. Pintus +12 more
doaj +1 more source
The profitability of P.G. 600® in well managed sow herd
Adequate results in reproduction are one of the key points for successful pig production. P.G. 600®, a combination of pregnant mare serum gonadotropine and human chorionic gonadotropine is used as oestrus promoter on many pig farms.
Miran KASTELIC, Stane KOŠOROK
doaj +1 more source
The role of noncoding genetic variants in cardiomyopathy
Cardiomyopathies remain one of the leading causes of morbidity and mortality worldwide. Environmental risk factors and genetic predisposition account for most cardiomyopathy cases.
Myo Htet +7 more
doaj +1 more source
A Meta-Analysis of Microarray Gene Expression in Mouse Stem Cells: Redefining Stemness [PDF]
Background: While much progress has been made in understanding stem cell (SC) function, a complete description of the molecular mechanisms regulating SCs is not yet established.
Bryson, Kevin +11 more
core +1 more source

