Results 31 to 40 of about 141,342 (308)
Unique activities of two overlapping PAX6 retinal enhancers [PDF]
, 2023 Enhancers play a critical role in development by precisely modulating spatial, temporal, and cell type-specific gene expression. Sequence variants in enhancers have been implicated in diseases; however, establishing the functional consequences of these ...
Lahne, M +6 more
core +4 more sources
eLife, 2017 Combinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear when this regulatory system evolved.
Federico Gaiti +5 more
doaj +1 more source
The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine, 2019 The range of opportunities people enjoy in life largely depends on social, biological, and genetic factors for which individuals are not responsible. Philosophical debates about equality of opportunities have focussed mainly on addressing social determinants of inequalities.
Giubilini, A, Minerva, F
openaire +2 more sources
Computational prediction of splicing regulatory elements shared by Tetrapoda organisms [PDF]
, 2009 Background: auxiliary splicing sequences play an important role in ensuring accurate and efficient splicing by promoting or repressing recognition of authentic splice sites.
Churbanov, Alexander +8 more
core +1 more source
Epigenomic Landscapes of hESC-Derived Neural Rosettes: Modeling Neural Tube Formation and Diseases
Cell Reports, 2017 We currently lack a comprehensive understanding of the mechanisms underlying neural tube formation and their contributions to neural tube defects (NTDs).
Cristina Valensisi +6 more
doaj +1 more source
Signatures of Recent Positive Selection in Enhancers Across 41 Human Tissues
G3: Genes, Genomes, Genetics, 2019 Evolutionary changes in enhancers are widely associated with variation in human traits and diseases. However, studies comprehensively quantifying levels of selection on enhancers at multiple evolutionary periods during recent human evolution and how ...
Jiyun M. Moon +3 more
doaj +1 more source
Super-enhancers are transcriptionally more active and cell-type-specific than stretch enhancers
, 2018 BackgroundSuper-enhancers and stretch enhancers represent classes of transcriptional enhancers that have been shown to control the expression of cell identity genes and carry disease- and trait-associated variants.
Aziz Khan +2 more
core +2 more sources
Role of enhancers in development and diseases [PDF]
, 2021 Enhancers are cis-regulatory elements containing short DNA sequences that serve as binding sites for pioneer/regulatory transcription factors, thus orchestrating the regulation of genes critical for lineage determination.
Maurya, Shailendra S +1 more
core +1 more source
An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice
eLife, 2019 Evolutionary studies are often limited by missing data that are critical to understanding the history of selection. Selection experiments, which reproduce rapid evolution under controlled conditions, are excellent tools to study how genomes evolve under ...
João PL Castro +12 more
doaj +1 more source
Psychopharmaceutical Enhancers: Enhancing Identity? [PDF]
Neuroethics, 2009 The use of psychopharmaceuticals to enhance human mental functioning such as cognition and mood has raised a debate on questions regarding identity and authenticity. While some hold that psychopharmaceutical substances can help users to ‘become who they really are’ and thus strengthen their identity and authenticity, others believe that the substances ...
Bolt, Ineke, Schermer, Maartje
openaire +2 more sources