Differentially methylated regions within lung cancer risk loci are enriched in deregulated enhancers
Epigenetics, 2022 Genome-wide association studies (GWAS) have identified SNPs linked with lung cancer risk. Our aim was to discover the genes, non-coding RNAs, and regulatory elements within GWAS-identified risk regions that are deregulated in non-small cell lung ...
Marina Laplana +14 more
doaj +1 more source
Psychopharmaceutical Enhancers: Enhancing Identity? [PDF]
Neuroethics, 2009 The use of psychopharmaceuticals to enhance human mental functioning such as cognition and mood has raised a debate on questions regarding identity and authenticity. While some hold that psychopharmaceutical substances can help users to ‘become who they really are’ and thus strengthen their identity and authenticity, others believe that the substances ...
Bolt, Ineke, Schermer, Maartje
openaire +2 more sources
A hierarchical model of transcriptional dynamics allows robust estimation of transcription rates in populations of single cells with variable gene copy number [PDF]
, 2013 Motivation: cis-regulatory DNA sequence elements, such as enhancers and silencers, function to control the spatial and temporal expression of their target genes.
Woodcock, Dan J +8 more
core +1 more source
eLife, 2017 Combinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear when this regulatory system evolved.
Federico Gaiti +5 more
doaj +1 more source
Epigenomic Landscapes of hESC-Derived Neural Rosettes: Modeling Neural Tube Formation and Diseases
Cell Reports, 2017 We currently lack a comprehensive understanding of the mechanisms underlying neural tube formation and their contributions to neural tube defects (NTDs).
Cristina Valensisi +6 more
doaj +1 more source
The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine, 2019 The range of opportunities people enjoy in life largely depends on social, biological, and genetic factors for which individuals are not responsible. Philosophical debates about equality of opportunities have focussed mainly on addressing social determinants of inequalities.
Giubilini, A, Minerva, F
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From enhanced coinduction towards enhanced induction [PDF]
Proceedings of the ACM on Programming Languages, 2022 There exist a rich and well-developed theory of enhancements of the coinduction proof method, widely used on behavioural relations such as bisimilarity. We study how to develop an analogous theory for inductive behaviour relations, i.e., relations defined from inductive observables.
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Signatures of Recent Positive Selection in Enhancers Across 41 Human Tissues
G3: Genes, Genomes, Genetics, 2019 Evolutionary changes in enhancers are widely associated with variation in human traits and diseases. However, studies comprehensively quantifying levels of selection on enhancers at multiple evolutionary periods during recent human evolution and how ...
Jiyun M. Moon +3 more
doaj +1 more source
An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice
eLife, 2019 Evolutionary studies are often limited by missing data that are critical to understanding the history of selection. Selection experiments, which reproduce rapid evolution under controlled conditions, are excellent tools to study how genomes evolve under ...
João PL Castro +12 more
doaj +1 more source
A novel Nodal enhancer dependent on pluripotency factors and Smad2/3 signaling conditions a regulatory switch during epiblast maturation [PDF]
, 2014 During early development, modulations in the expression of Nodal, a TGFβ family member, determine the specification of embryonic and extra-embryonic cell identities.
Jérôme Collignon (34631) +29 more
core +1 more source