Results 11 to 20 of about 4,995,766 (296)

Streamlined scanning for enhancer elements in Drosophila melanogaster

BioTechniques, 2016
Enhancer elements in most eukaryotic organisms are often positioned at a great distance away from the transcription start site of the gene they regulate. Complex three-dimensional chromatin organization and insulators usually guide and limit the range of
Roumen Voutev, Richard S. Mann
doaj   +2 more sources

Genetic effects of sequence-conserved enhancer-like elements on human complex traits

Genome Biology, 2022
Background The vast majority of findings from human genome-wide association studies (GWAS) map to non-coding sequences, complicating their mechanistic interpretations and clinical translations.
Xiang Zhu, Shining Ma, Wing Hung Wong
doaj   +3 more sources

Modeling antenna array elements and bandwidth enhanced by genetic algorithm [PDF]

IEEE Antennas and Propagation Society International Symposium. Digest. Held in conjunction with: USNC/CNC/URSI North American Radio Sci. Meeting (Cat. No.03CH37450), 2004
A systematic approach for optimal design of broadband antenna arrays is proposed. The method is based on circuit modeling of the antenna array and optimization with genetic algorithm. An optimal design of a printed dipole antenna array is demonstrated.
Liu, Yu-Hao, Liu, An-Shyi, Pang, Yi-Hsin, Wu, Ruey-Beei   +3 more
openaire   +2 more sources

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer [PDF]

Journal of Clinical Investigation, 2012
The contraction pattern of the heart relies on the activation and conduction of the electrical impulse. Perturbations of cardiac conduction have been associated with congenital and acquired arrhythmias as well as cardiac arrest. The pattern of conduction depends on the regulation of heterogeneous gene expression by key transcription factors and ...
Boogaard, M. van den, Wong, L.Y.E., Tessadori, F., Bakker, M.L., Dreizehnter, L.K., Wakker, V., Bezzina, C.R., Hoen, P.A.C. 't, Bakkers, J., Barnett, P., Christoffels, V.M.   +10 more
openaire   +6 more sources

Enhancers in embryonic stem cells are enriched for transposable elements and genetic variations associated with cancers [PDF]

Nucleic Acids Research, 2011
Using an enhancer-associated epigenetic signature, we made genome-wide predictions of transcriptional enhancers in human B and T lymphocytes and embryonic stem cells (ES cells). We validated and characterized the predicted enhancers using four types of information, including overlap with other genomic marks for enhancers; association with cell-type ...
Teng, Li, Firpi, Hiram A., Tan, Kai
openaire   +2 more sources

Molecular Genetic Analysis of Drosophila eyes absent Mutants Reveals an Eye Enhancer Element [PDF]

Genetics, 2000
Abstract The eyes absent (eya) gene is critical for normal eye development in Drosophila and is highly conserved to vertebrates. To define regions of the gene critical for eye function, we have defined the mutations in the four viable eya alleles.
J E, Zimmerman, Q T, Bui, H, Liu, N M, Bonini   +3 more
openaire   +2 more sources

The role of antibiotic resistance mobile genetic element MCR-1 in enhancing bacterial survival in macrophages

Journal of Emergency Medicine, Trauma & Acute Care, 2021
Background: Antimicrobial resistance (AMR) determinants such as mobile colistin resistance (MCR-1) that encodes colistin resistance are increasingly spreading in healthcare-associated and community-acquired infections.
Hashim, Amina, Elgamal, Mahmoud, Chowdhury, Shazeda H., Hattab, Fatima A., Al-Shibly, Rafal, Eltai, Nahla, Al-Thani, Asmaa, Zughaier, Susu M.   +7 more
openaire   +2 more sources

Recent advances in high-throughput approaches to dissect enhancer function [version 1; referees: 3 approved]

F1000Research, 2017
The regulation of gene transcription in higher eukaryotes is accomplished through the involvement of transcription start site (TSS)-proximal (promoters) and -distal (enhancers) regulatory elements.
David Santiago-Algarra, Lan T.M. Dao, Lydie Pradel, Alexandre España, Salvatore Spicuglia   +4 more
doaj   +1 more source

Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome. [PDF]

, 2015
Enhancers can regulate the transcription of genes over long genomic distances. This is thought to lead to selection against genomic rearrangements within such regions that may disrupt this functional linkage.
Rinkwitz, S, Bally-Cuif, Laure, Chilamakuri, Chandra S R, Wilson, David I., Ishibashi, M, Rinkwitz, Silke, Wilson, SW, Crollius, H. R., Hawkins, Thomas A., Becker, Thomas S, Wilson, Stephen W., Strähle, U., Becker, TS, Rastegar, S., Lenhard, B., Hawkins, TA, Raymond, F. L., Chilamakuri, CS, Hawkins, T. A., Louis, A., Louis, A, Louis, Alexandra, Wilson, D. I., Chilamakuri, Chandra S. R., Hawkins, Thomas A, Ishibashi, Minaka, Crollius, Hugues Roest, Naville, M., Strähle, U, Wilson, S. W., Rastegar, Sepand, Lenhard, Boris, Becker, Thomas S., Straehle, Uwe, Manning, E, Bally-Cuif, L., FitzPatrick, David R., Bengani, H, Manning, E., Rastegar, S, Ferg, M, Roest Crollius, Hugues, Heyningen, V. van, Roest Crollius, H, Ferg, Marco, Bengani, Hemant, Lucy Raymond, F., Lucy Raymond, F, Naville, Magali, Krecsmarik, Monika, FitzPatrick, D. R., Bengani, H., Chilamakuri, C. S. R., Wilson, Stephen W, Ishibashi, M., Naville, M, Wilson, David I, van Heyningen, V, Bally-Cuif, L, Wilson, DI, Rinkwitz, S., Strähle, Uwe, Chilamakuri, Chandra Sekhar Reddy, FitzPatrick, DR, Raymond, F. Lucy, Ferg, M., Krecsmarik, M, Becker, T. S., van Heyningen, Veronica, Lenhard, B, Manning, Elizabeth, Krecsmarik, M., Fitzpatrick, David R   +72 more
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A Very Strong Enhancer Is Located Upstream of an Immediate Early Gene of Human Cytomegalovirus [PDF]

, 1985
A strong transcription enhancer was identified in the genomic DNA (235 kb) of human cytomegalovirus (HCMV), a ubiquitous and severe pathogen of the herpesvirus group.
Boshart, Michael, Schaffner, Walter, Weber, Frank, Jahn, Gerhard, Dorsch-Häsler, Karoline, Fleckenstein, Bernhard   +5 more
core   +1 more source