Results 31 to 40 of about 88,833 (257)

Blood disease–causing and –suppressing transcriptional enhancers: general principles and GATA2 mechanisms

Blood Advances, 2019
: Intensive scrutiny of human genomes has unveiled considerable genetic variation in coding and noncoding regions. In cancers, including those of the hematopoietic system, genomic instability amplifies the complexity and functional consequences of ...
Emery H. Bresnick, Kirby D. Johnson
doaj   +1 more source

Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus [PDF]

, 2011
We provide experimental evidence of a replication enhancer element (REE) within the capsid gene of tick-borne encephalitis virus (TBEV, genus Flavivirus).
I. M. Jones, Gould, EA, Tuplin, Andrew, Gould, E. A., A. Buckley, E. A. Gould, A. Tuplin, Tuplin, A., Jones, I. M., Jones, I. M. (Ian M.), Buckley, A., Gould, E., T. S. Gritsun, Jones, IM, Gritsun, T. S., Tuplin, A, Evans, DJ, Evans, David J., Gritsun, TS, D. J. Evans, Evans, D. J., Buckley, A   +21 more
core   +1 more source

Genomic Knockout of Two Presumed Forelimb Tbx5 Enhancers Reveals They Are Nonessential for Limb Development

Cell Reports, 2018
Summary: A standard approach in the identification of transcriptional enhancers is the use of transgenic animals carrying DNA elements joined to reporter genes inserted randomly in the genome.
Thomas J. Cunningham, Joseph J. Lancman, Marie Berenguer, P. Duc Si Dong, Gregg Duester   +4 more
doaj   +1 more source

Comparative analysis on the structural features of the 5' flanking region of kappa-casein genes from six different species [PDF]

, 2002
Kappa-casein plays an essential role in the formation, stabilisation and aggregation of milk micelles. Control of kappa-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other ...
C. Bruce A. Whitelaw,, Whitelaw, C Bruce A, Zsuzsanna Bösze, Bösze, Zsuzsanna, Kastanis, Petros, Barta, Endre, Simon Boa, Boa, Simon, �kos Gerencs�r, Petros Kastanis, C. Bruce A. Whitelaw, Zsuzsanna B�sze, Endre Barta, Gerencsér, Akos, Ákos Gerencsér, Whitelaw, C. Bruce A., C Bruce A Whitelaw   +16 more
core   +1 more source

Androgen Receptor-Mediated Transcription in Prostate Cancer

Cells, 2022
Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate cancer (PCa) growth and differentiation. This process involves a complex interplay of coregulatory proteins, chromatin remodeling complexes, and other ...
Doğancan Özturan, Tunç Morova, Nathan A. Lack   +2 more
doaj   +1 more source

PEACOCK: a machine learning approach to assess the validity of cell type-specific enhancer-gene regulatory relationships

npj Systems Biology and Applications, 2023
The vast majority of disease-associated variants identified in genome-wide association studies map to enhancers, powerful regulatory elements which orchestrate the recruitment of transcriptional complexes to their target genes’ promoters to upregulate ...
Caitlin Mills, Crystal N. Marconett, Juan Pablo Lewinger, Huaiyu Mi   +3 more
doaj   +1 more source

Genetic dissection of the α-globin super-enhancer in vivo [PDF]

, 2016
Many genes determining cell identity are regulated by clusters of Mediator-bound enhancer elements collectively referred to as super-enhancers. These super-enhancers have been proposed to manifest higher-order properties important in development and ...
Davies, James O.J., Ayyub, H., Ruth Williams, Davies, James O J, Li, Pik-Shan, Oudelaar, A Marieke, Li, PS, Suciu, Maria C, Jim R Hughes, Wood, W., Kassouf, Mira T., Li, Pik Shan, Oudelaar, AM, Rode, C, Jelena Telenius, Kassouf, Mira T, Ayyub, H, Hanssen, Lars LP, Sharpe, JA, Smith, Andrew J H, Suciu, Maria C., Telenius, Jelena, Davies, J., Suciu, MC, Tatjana Sauka-Spengler, Babbs, C, Hughes, J., Higgs, Douglas R., Williams, R., Jacqueline A Sloane-Stanley, Sharpe, Jacqueline A., Hanssen, L., Sloane-Stanley, Jacqueline A., Hanssen, Lars L.P., Hughes, Jim R, Sue Butler, Sauka-Spengler, T, Suciu, M., Pennacchio, Len A., Rode, Christina, Ayyub, Helena, Hay, D., Hay, Deborah, Rode, C., Graham, Bryony J, Hughes, JR, Telenius, J, Richard J Gibbons, Bryony J Graham, Williams, R, Sloane-Stanley, Jacqueline A, Pennacchio, Len A, Butler, Sue, Gibbons, Richard J., Graham, Bryony J., Helena Ayyub, Hanssen, LLP, Andrew J H Smith, Babbs, C., Christian Babbs, Graham, BJ, Gibbons, Richard J, Kassouf, MT, Williams, Ruth; id_orcid, Sloane-Stanley, Jaqcueline A., Sharpe, Jacqueline A, Wood, William G., Pik-Shan Li, Sloane-Stanley, JA, Butler, S, Lars L P Hanssen, Davies, JOJ, Higgs, DR, Hanssen, Lars L P, Jacqueline A Sharpe, Wood, William G, A Marieke Oudelaar, Higgs, Douglas R, Sharpe, J., Telenius, J., Pennacchio, L., Babbs, Christian, Wood, WG, Oudelaar, A., Len A Pennacchio, Maria C Suciu, Oudelaar, A. Marieke, Butler, S., Christina Rode, Williams, Ruth, Higgs, D., Sloane-Stanley, J., Smith, A., Smith, AJH, Gibbons, R, Li, P., Gibbons, R., Smith, Andrew J.H., Douglas R Higgs, Sauka-Spengler, T., Deborah Hay, Hughes, Jim R., Mira T Kassouf, Smith, Andrew JH, William G Wood, Graham, B., Pennacchio, LA, Gibbons, Richard, Kassouf, M., Davies, James OJ, Sauka-Spengler, Tatjana, James O J Davies   +111 more
core   +1 more source

miREE: miRNA Recognition Elements Ensemble [PDF]

, 2011
Background Computational methods for microRNA target prediction are a fundamental step to understand the miRNA role in gene regulation, a key process in molecular biology. In this paper we present miREE, a novel microRNA target prediction tool.
Enrico Macii, Acquaviva, Andrea, Paula H Reyes-Herrera, Macii Enrico, Acquaviva Andrea, REYES HERRERA, PAULA HELENA, Andrea Acquaviva, Elisa Ficarra, Ficarra, Elisa, Reyes-Herrera Paula H, Macii, Enrico, Ficarra Elisa, Reyes Herrera Ph   +12 more
core   +1 more source

Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism

Cell Reports, 2018
Summary: Transcriptional dysregulation of the MYC oncogene is among the most frequent events in aggressive tumor cells, and this is generally accomplished by acquisition of a super-enhancer somewhere within the 2.8 Mb TAD where MYC resides.
Jurian Schuijers, John Colonnese Manteiga, Abraham Selby Weintraub, Daniel Sindt Day, Alicia Viridiana Zamudio, Denes Hnisz, Tong Ihn Lee, Richard Allen Young   +7 more
doaj   +1 more source

Understanding the Dynamics of Gene Regulatory Systems : Characterisation and Clinical Relevance of cis-Regulatory Polymorphisms [PDF]

, 2013
Peer ...
MacKenzie, Alasdair, Philip Cowie, Alasdair MacKenzie, Cowie, Philip David, Ross, Ruth, Ruth Ross   +5 more
core   +1 more source