Results 31 to 40 of about 4,995,766 (296)

Staphylococcus petrasii diagnostics and its pathogenic potential enhanced by mobile genetic elements

International Journal of Medical Microbiology, 2019
Staphylococcus petrasii is recently described coagulase negative staphylococcal species and an opportunistic human pathogen, still often misidentified in clinical specimens. Four subspecies are distinguished in S. petrasii by polyphasic taxonomical analyses, however a comparative study has still not been done on the majority of isolates and their ...
Veronika, Vrbovská, Vojtěch, Kovařovic, Ivana, Mašlaňová, Adéla, Indráková, Petr, Petráš, Ondrej, Šedo, Pavel, Švec, Lenka, Fišarová, Marta, Šiborová, Kamil, Mikulášek, Ivo, Sedláček, Jiří, Doškař, Roman, Pantůček   +12 more
openaire   +2 more sources

eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways

eLife, 2023
Cancer is driven by both genetic and epigenetic changes that impact on gene expression profiles and the resulting tumourigenic phenotype. Enhancers are transcriptional regulatory elements that are key to our understanding of how this rewiring of gene ...
Ibrahim Ahmed, Shen-Hsi Yang, Samuel Ogden, Wei Zhang, Yaoyong Li, The OCCAMs consortium, Andrew D Sharrocks   +6 more
doaj   +1 more source

An E box comprises a positional sensor for regional differences in skeletal muscle gene expression and methylation [PDF]

, 1999
To dissect the molecular mechanisms conferring positional information in skeletal muscles, we characterized the control elements responsible for the positionally restricted expression patterns of a muscle-specific transgene reporter, driven by regulatory
McGrew, M J; id_orcid, Nguyen, T, Horgan, D, Grieshammer, U, Ceccarelli, E, Rosenthal, N, Hughes, S H   +6 more
core   +1 more source

AKT-mediated phosphorylation of Sox9 induces Sox10 transcription in a murine model of HER2-positive breast cancer

Breast Cancer Research, 2021
Background Approximately 5–10% of HER2-positive breast cancers can be defined by low expression of the Ste20-like kinase, SLK, and high expression of SOX10.
Khalid N. Al-Zahrani, John Abou-Hamad, Julia Pascoal, Cédrik Labrèche, Brennan Garland, Luc A. Sabourin   +5 more
doaj   +1 more source

Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer

Genome Medicine, 2021
Background Enhancers are distal cis-regulatory elements required for cell-specific gene expression and cell fate determination. In cancer, enhancer variation has been proposed as a major cause of inter-patient heterogeneity—however, most predicted ...
Taotao Sheng, Shamaine Wei Ting Ho, Wen Fong Ooi, Chang Xu, Manjie Xing, Nisha Padmanabhan, Kie Kyon Huang, Lijia Ma, Mohana Ray, Yu Amanda Guo, Ngak Leng Sim, Chukwuemeka George Anene-Nzelu, Mei Mei Chang, Milad Razavi-Mohseni, Michael A. Beer, Roger Sik Yin Foo, Raghav Sundar, Yiong Huak Chan, Angie Lay Keng Tan, Xuewen Ong, Anders Jacobsen Skanderup, Kevin P. White, Sudhakar Jha, Patrick Tan   +23 more
doaj   +1 more source

Broadening our understanding of the genetics of Juvenile Idiopathic Arthritis (JIA): Interrogation of three dimensional chromatin structures and genetic regulatory elements within JIA-associated risk loci.

PLoS ONE, 2020
ObjectiveThe risk loci for juvenile idiopathic arthritis (JIA) consist of extended haplotypes that include functional elements in addition to canonical coding genes.
Kaiyu Jiang, Haeja Kessler, Yungki Park, Marc Sudman, Susan D Thompson, James N Jarvis   +5 more
doaj   +1 more source

Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer [PDF]

BMC Medical Genetics, 2015
Common genetic variants residing near upstream regulatory elements for MYB, the gene encoding transcription factor cMYB, promote the persistence of fetal hemoglobin (HbF) into adulthood. While they have no consequences in healthy individuals, high HbF levels have major clinical benefits in patients with sickle cell disease (SCD) or β thalassemia. Here,
Mtatiro, Siana N., Mgaya, Josephine, Singh, Tarjinder, Mariki, Harvest, Rooks, Helen, Soka, Deogratius, Mmbando, Bruno, Thein, Swee Lay, Barrett, Jeffrey C., Makani, Julie, Cox, Sharon E., Menzel, Stephan   +11 more
openaire   +7 more sources

Blood disease–causing and –suppressing transcriptional enhancers: general principles and GATA2 mechanisms

Blood Advances, 2019
: Intensive scrutiny of human genomes has unveiled considerable genetic variation in coding and noncoding regions. In cancers, including those of the hematopoietic system, genomic instability amplifies the complexity and functional consequences of ...
Emery H. Bresnick, Kirby D. Johnson
doaj   +1 more source

Genetic dissection of the α-globin super-enhancer in vivo [PDF]

, 2016
Many genes determining cell identity are regulated by clusters of Mediator-bound enhancer elements collectively referred to as super-enhancers. These super-enhancers have been proposed to manifest higher-order properties important in development and ...
Davies, James O.J., Ayyub, H., Ruth Williams, Davies, James O J, Li, Pik-Shan, Oudelaar, A Marieke, Suciu, Maria C, Jim R Hughes, Wood, W., Kassouf, Mira T., Li, Pik Shan, Jelena Telenius, Kassouf, Mira T, Hanssen, Lars LP, Smith, Andrew J H, Suciu, Maria C., Telenius, Jelena, Davies, J., Tatjana Sauka-Spengler, Hughes, J., Higgs, Douglas R., Williams, R., Jacqueline A Sloane-Stanley, Sharpe, Jacqueline A., Hanssen, L., Sloane-Stanley, Jacqueline A., Hanssen, Lars L.P., Hughes, Jim R, Sue Butler, Suciu, M., Pennacchio, Len A., Rode, Christina, Ayyub, Helena, Hay, D., Hay, Deborah, Rode, C., Graham, Bryony J, Richard J Gibbons, Bryony J Graham, Sloane-Stanley, Jacqueline A, Pennacchio, Len A, Butler, Sue, Gibbons, Richard J., Graham, Bryony J., Helena Ayyub, Andrew J H Smith, Babbs, C., Christian Babbs, Gibbons, Richard J, Williams, Ruth; id_orcid, Sharpe, Jacqueline A, Wood, William G., Pik-Shan Li, Lars L P Hanssen, Hanssen, Lars L P, Jacqueline A Sharpe, Wood, William G, A Marieke Oudelaar, Higgs, Douglas R, Sharpe, J., Telenius, J., Pennacchio, L., Babbs, Christian, Oudelaar, A., Len A Pennacchio, Maria C Suciu, Oudelaar, A. Marieke, Butler, S., Christina Rode, Williams, Ruth, Higgs, D., Sloane-Stanley, J., Smith, A., Li, P., Gibbons, R., Smith, Andrew J.H., Douglas R Higgs, Sauka-Spengler, T., Deborah Hay, Hughes, Jim R., Mira T Kassouf, Smith, Andrew JH, William G Wood, Graham, B., Kassouf, M., Davies, James OJ, Sauka-Spengler, Tatjana, James O J Davies   +87 more
core   +1 more source

Genomic Knockout of Two Presumed Forelimb Tbx5 Enhancers Reveals They Are Nonessential for Limb Development

Cell Reports, 2018
Summary: A standard approach in the identification of transcriptional enhancers is the use of transgenic animals carrying DNA elements joined to reporter genes inserted randomly in the genome.
Thomas J. Cunningham, Joseph J. Lancman, Marie Berenguer, P. Duc Si Dong, Gregg Duester   +4 more
doaj   +1 more source