Results 21 to 30 of about 4,995,766 (296)

Assessment of de novo copy-number variations in Italian patients with schizophrenia: Detection of putative mutations involving regulatory enhancer elements [PDF]

, 2017
Objectives: Variants appearing de novo in genes regulating key neurodevelopmental processes and/or in non-coding cis-regulatory elements (CREs), as enhancers, may increase the risk for schizophrenia. However, CREs involvement in schizophrenia needs to be
Bellomo, Antonello, Roberto Brugnoli, Valentina Montefusco, Giuseppe Plescia, Francesca, Pacitti, Maria Salvina, Signorelli, Gambi, Francesco, Stratta, Paolo, Giulio, Corrivetti, Roncone, Rita, Tiziano, Acciavatti, Maj, Mario, Nigro, Vincenzo, Cinzia, Niolu, Santonastaso, Paolo, Giuseppe Piegari, Annalisa, Camerlengo, Sacchetti, Emilio, Eleonora Merlotti, Fagiolini, Andrea, Gaetano, Callista, Bucci, Paola, Fabio, Liliana, Dell’Osso, Paolo, Valsecchi, Comparelli, Anna, Costanza, Arzani, Marchesi, Carlo, Lucio, Oldani, Andriola, Ileana, Monteleone, Palmiero, Elena, Tenconi, Tortorella, Alfonso, Giugliano, Teresa, Carla, Gramaglia, Galderisi, Silvana, Anna Rita, Atti, Bertolino, Alessandro, Enrico, D’Ambrosio, Marco, Savarese, Simone, Bolognesi, Di Fabio, Cristina Montemagni., Aguglia, Eugenio, Monica, Cimmino, Rocca, Paola, Mario, Altamura, Rossi, Alessandro, Steardo, Luca, Mucci, Armida, Piluso, Giulio, Siracusano, Alberto   +51 more
core   +4 more sources

A genomic-scale view of the cAMP response element-enhancer decoy: A tumor target-based genetic tool [PDF]

Proceedings of the National Academy of Sciences, 2002
Enhancer DNA decoy oligodeoxynucleotides (ODNs) inhibit transcription by competing for transcription factors. A decoy ODN composed of the cAMP response element (CRE) inhibits CRE-directed gene transcription and tumor growth without affecting normal cell growth.
Yee Sook, Cho, Meyoung-Kon, Kim, Chris, Cheadle, Catherine, Neary, Yun Gyu, Park, Kevin G, Becker, Yoon S, Cho-Chung   +6 more
openaire   +2 more sources

Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro [PDF]

, 1988
The possibility of DNA-binding proteins interacting in vitro with the polymerase II transcriptional machinery was explored by using a competition assay with individual target sequences for enhancer-binding factors.
Lubon, H, Lubon, Henryk, Hennighausen, L, Hennighausen, Lothar, Ghazal, Peter, Ghazal, P   +5 more
core   +1 more source

A constitutive enhancer in the bovine papillomavirus upstream regulatory region shares genetic elements with the viral P1 promoter [PDF]

Journal of Virology, 1992
The bovine papillomavirus upstream regulatory region represents a common element in the regulation of transcription from the five early viral promoters. We have determined the sequences required for transcription from the viral P1 promoter, which is located at the 5' end of the upstream regulatory region.
G L, Bream, P, Vaillancourt, M R, Botchan   +2 more
openaire   +2 more sources

Multimodal single cell analysis infers widespread enhancer co-activity in a lymphoblastoid cell line

Communications Biology, 2023
Non-coding regulatory elements such as enhancers are key in controlling the cell-type specificity and spatio-temporal expression of genes. To drive stable and precise gene transcription robust to genetic variation and environmental stress, genes are ...
Chaymae Ziyani, Olivier Delaneau, Diogo M. Ribeiro   +2 more
doaj   +1 more source

Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity

eLife, 2019
Enhancers are important regulatory elements that can control gene activity across vast genetic distances. However, the underlying nature of this regulation remains obscured because it has been difficult to observe in living cells.
Jeffrey M Alexander, Juan Guan, Bingkun Li, Lenka Maliskova, Michael Song, Yin Shen, Bo Huang, Stavros Lomvardas, Orion D Weiner   +8 more
doaj   +1 more source

Enhancer/gene relationships: Need for more reliable genome-wide reference sets

Frontiers in Bioinformatics, 2023
Differences in cells’ functions arise from differential activity of regulatory elements, including enhancers. Enhancers are cis-regulatory elements that cooperate with promoters through transcription factors to activate the expression of one or several ...
Tristan Hoellinger, Tristan Hoellinger, Camille Mestre, Hugues Aschard, Hugues Aschard, Wilfried Le Goff, Sylvain Foissac, Thomas Faraut, Sarah Djebali, Sarah Djebali   +9 more
doaj   +1 more source

Genetic and molecular analysis of the Enhancer (En) transposable element system of Zea mays

The EMBO Journal, 1985
A newly isolated, unstable mutation wx-844::En-1 of Zea mays was proven to be caused by the insertion of the autonomous transposable element En into the Waxy (Wx) gene. Molecular analysis revealed that En-1 is 8.4 kb long, has a 13-bp long perfect inverted repeat at its termini and generates a 3-bp target site duplication.
A, Pereira, Z, Schwarz-Sommer, A, Gierl, I, Bertram, P A, Peterson, H, Saedler   +5 more
openaire   +2 more sources

Enhancer Cis Elements Instruct Enhancer-Promoter Interaction, Enhancer-Promoter Insulation and Compartmental Segregation [PDF]

, 2022
Enhancers harbor instructions encoded for the interactions between cis-elements and transcription factors to orchestrate lineage specific gene programs.
Lu, Hanbin
core   +1 more source

The strong enhancer element in the immediate early region of the human cytomegalovirus genome [PDF]

, 1985
The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-
Boshart, Michael, Schaffner, Walter, Weber, Frank, Dorsch-Häsler, Karoline, Jahn, Gerhard, Rüger, Rüdiger, Fleckenstein, Bernhard, Stoerker, Jay, Calendar, R., Gold, L.   +9 more
core   +1 more source