Results 21 to 30 of about 88,833 (257)

Regulation of inflammation in diabetes: From genetics to epigenomics evidence

Molecular Metabolism, 2020
Background: Diabetes is one of the greatest public health challenges worldwide, and we still lack complementary approaches to significantly enhance the efficacy of preventive and therapeutic approaches.
Marc Diedisheim, Elena Carcarino, Claire Vandiedonck, Ronan Roussel, Jean-François Gautier, Nicolas Venteclef   +5 more
doaj   +1 more source

Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals

Nature Communications, 2021
Genetic elements that control inflammatory gene expression are not fully elucidated. Here the authors conduct a multi-species analysis of chromatin landscape and NF-κB binding in response to the proinflammatory cytokine TNFα, finding that conserved NF-κB
Azad Alizada, Nadiya Khyzha, Liangxi Wang, Lina Antounians, Xiaoting Chen, Melvin Khor, Minggao Liang, Kumaragurubaran Rathnakumar, Matthew T. Weirauch, Alejandra Medina-Rivera, Jason E. Fish, Michael D. Wilson   +11 more
doaj   +1 more source

Assessment of de novo copy-number variations in Italian patients with schizophrenia: Detection of putative mutations involving regulatory enhancer elements [PDF]

, 2017
Objectives: Variants appearing de novo in genes regulating key neurodevelopmental processes and/or in non-coding cis-regulatory elements (CREs), as enhancers, may increase the risk for schizophrenia. However, CREs involvement in schizophrenia needs to be
Bellomo, Antonello, Roberto Brugnoli, Valentina Montefusco, Giuseppe Plescia, Francesca, Pacitti, Maria Salvina, Signorelli, Gambi, Francesco, Stratta, Paolo, Giulio, Corrivetti, Roncone, Rita, Tiziano, Acciavatti, Maj, Mario, Nigro, Vincenzo, Cinzia, Niolu, Santonastaso, Paolo, Giuseppe Piegari, Annalisa, Camerlengo, Sacchetti, Emilio, Eleonora Merlotti, Fagiolini, Andrea, Gaetano, Callista, Bucci, Paola, Fabio, Liliana, Dell’Osso, Paolo, Valsecchi, Comparelli, Anna, Costanza, Arzani, Marchesi, Carlo, Lucio, Oldani, Andriola, Ileana, Monteleone, Palmiero, Elena, Tenconi, Tortorella, Alfonso, Giugliano, Teresa, Carla, Gramaglia, Galderisi, Silvana, Anna Rita, Atti, Bertolino, Alessandro, Enrico, D’Ambrosio, Marco, Savarese, Simone, Bolognesi, Di Fabio, Cristina Montemagni., Aguglia, Eugenio, Monica, Cimmino, Rocca, Paola, Mario, Altamura, Rossi, Alessandro, Steardo, Luca, Mucci, Armida, Piluso, Giulio, Siracusano, Alberto   +51 more
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Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome. [PDF]

, 2014
Enhancers can regulate the transcription of genes over long genomic distances. This is thought to lead to selection against genomic rearrangements within such regions that may disrupt this functional linkage.
Rinkwitz, S, Bally-Cuif, Laure, Chilamakuri, Chandra S R, Wilson, David I., Ishibashi, M, Rinkwitz, Silke, Wilson, SW, Crollius, H. R., Hawkins, Thomas A., FitzPatrick, David R, Becker, Thomas S, Wilson, Stephen W., Strähle, U., Becker, TS, Rastegar, S., Lenhard, B., Hawkins, TA, Raymond, F. L., Chilamakuri, CS, Hawkins, T. A., Louis, A., Louis, A, Louis, Alexandra, Wilson, D. I., Chilamakuri, Chandra S. R., Hawkins, Thomas A, Ishibashi, Minaka, Crollius, Hugues Roest, Naville, M., Strähle, U, Wilson, S. W., Rastegar, Sepand, Lenhard, Boris, Becker, Thomas S., Straehle, Uwe, Manning, E, Bally-Cuif, L., FitzPatrick, David R., Bengani, H, Manning, E., Rastegar, S, Ferg, M, Roest Crollius, Hugues, Heyningen, V. van, Roest Crollius, H, Ferg, Marco, Bengani, Hemant, Lucy Raymond, F., Lucy Raymond, F, Naville, Magali, Krecsmarik, Monika, FitzPatrick, D. R., Bengani, H., Chilamakuri, C. S. R., Wilson, Stephen W, Ishibashi, M., Naville, M, Wilson, David I, van Heyningen, V, Bally-Cuif, L, Wilson, DI, Rinkwitz, S., Strähle, Uwe, Chilamakuri, Chandra Sekhar Reddy, FitzPatrick, DR, Raymond, F. Lucy, Ferg, M., Krecsmarik, M, Becker, T. S., van Heyningen, Veronica, Lenhard, B, Manning, Elizabeth, Krecsmarik, M.   +72 more
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An E box comprises a positional sensor for regional differences in skeletal muscle gene expression and methylation [PDF]

, 1999
To dissect the molecular mechanisms conferring positional information in skeletal muscles, we characterized the control elements responsible for the positionally restricted expression patterns of a muscle-specific transgene reporter, driven by regulatory
Hughes, Stephen H., Grieshammer, Uta, McGrew, Michael J., Nguyen, Tom, McGrew, M J; id_orcid, Nguyen, T, Horgan, D, Grieshammer, U, Ceccarelli, E, Ceccarelli, Elena, Rosenthal, Nadia, Horgan, David, Rosenthal, N, Hughes, S H   +13 more
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Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene [PDF]

, 1987
Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified by gene transfer experiments and shown to bind to purified glucocorticoid receptor.
Strähle, Uwe, Boshart, Michael, Schmid, Wolfgang, Miksicek, Richard, Jansen, Hans-Michael, Gloss, Bernd, Schlitz, Günther, Stewart, Francis   +7 more
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Highly conserved elements discovered in vertebrates are present in non-syntenic loci of tunicates, act as enhancers and can be transcribed during development [PDF]

, 2013
Co-option of cis-regulatory modules has been suggested as a mechanism for the evolution of expression sites during development. However, the extent and mechanisms involved in mobilization of cisregulatory modules remains elusive.
Meola, Nicola, Basu, Swaraj, Roure A, Brown, Euan R, Hadzhiev, Y., Brown E, Lemaire P, Amore, G., Strähle, U., Simone, M. de, Hadzhiev, Yavor, Stupka E., Müller F, Banfi, Sandro, Roure, A., Birney, E., Gueroult-Bellone, Marion, De Simone, Marco, Gueroult-Bellone, M., Amore, Gabriele, Roure, Agnes, Ferg M, Licastro, Danilo, Basu, S., Petrera, F., Sanges, R., Brown, Euan R., Gueroult Bellone M, Sanges R, Stupka, Elia, Ferg, Marco, Strähle U, Lemaire, P., Müller, F., Strahle, Uwe, Birney, Ewan, Brown, Euan R; id_orcid, Brown, E. R., Basu S, Stupka, E., Muller, Ferenc, De Simone M, Petrera, Francesca, Petrera F, Lemaire, Patrick, Licastro, D., Sanges, Remo, Hadzhiev Y, Banfi, S., Meola N, Meola, N., Licastro D, Ferg, M., Amore G, Birney E   +54 more
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Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells [PDF]

, 2002
Expression of the gene for the macrophage colony stimulating factor receptor (CSF-1R), c-fms, has been viewed as a hallmark of the commitment of multipotent precursor cells to macrophages.
Bonifer, Constanze, Pieter J.M. Leenen, Himes, R, Clarke, D, Himes, Roy, Riggs, A. D., Bonifer, Constanze; id_orcid, Tagoh, H., Tagoh, Hiromi, Hume, David, Himes, R., Tagoh, H, Hume, D., Leenen, PJ, Roy Himes, Clarke, D., Bonifer, C, Leenen, Pieter J M, Constanze Bonifer, David Hume, Riggs, AD, Bonifer, C., Leenen, P. J. M., Arthur D. Riggs, Leenen, Pieter, Clarke, Deborah, Hiromi Tagoh, Deborah Clarke, Riggs, Arthur D, Hume, D   +29 more
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Broadening our understanding of the genetics of Juvenile Idiopathic Arthritis (JIA): Interrogation of three dimensional chromatin structures and genetic regulatory elements within JIA-associated risk loci.

PLoS ONE, 2020
ObjectiveThe risk loci for juvenile idiopathic arthritis (JIA) consist of extended haplotypes that include functional elements in addition to canonical coding genes.
Kaiyu Jiang, Haeja Kessler, Yungki Park, Marc Sudman, Susan D Thompson, James N Jarvis   +5 more
doaj   +1 more source

Role of cyclic AMP in the control of cell-specific gene expression [PDF]

, 1993
Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael, Schmid, Wolfgang, Schütz, Günther, Nitsch, Doris   +3 more
core   +1 more source