Results 41 to 50 of about 88,833 (257)

Enhancer requirement for murine cytomegalovirus growth and genetic complementation by the human cytomegalovirus enhancer [PDF]

, 1998
The cytomegalovirus (CMV) enhancer is a highly complex regulatory region containing multiple elements that interact with a variety of host-encoded transcription factors. Many of these sequence elements are conserved among the different species strains of
Angulo, A, Koszinowski, U H, Messerle, M, Ghazal, P   +3 more
core   +1 more source

Wellington : a novel method for the accurate identification of digital genomic footprints from DNase-seq data [PDF]

, 2013
The expression of eukaryotic genes is regulated by cis-regulatory elements such as promoters and enhancers, which bind sequence-specific DNA-binding proteins.
Bonifer, Constanze, Piper, Jason, Cockerill, Peter N., Elze, Markus C., Cockerill, Peter N, Bonifer, Constanze; id_orcid, Ott, Sascha, Elze, Markus C, Cauchy, Pierre   +8 more
core   +1 more source

Epigenomic profiling of primary gastric adenocarcinoma reveals super-enhancer heterogeneity [PDF]

, 2016
Regulatory enhancer elements in solid tumours remain poorly characterized. Here we apply micro-scale chromatin profiling to survey the distal enhancer landscape of primary gastric adenocarcinoma (GC), a leading cause of global cancer mortality ...
라선영
core   +1 more source

Regulatory Architecture of the RCA Gene Cluster Captures an Intragenic TAD Boundary, CTCF-Mediated Chromatin Looping and a Long-Range Intergenic Enhancer

Frontiers in Immunology, 2022
The Regulators of Complement Activation (RCA) gene cluster comprises several tandemly arranged genes with shared functions within the immune system. RCA members, such as complement receptor 2 (CR2), are well-established susceptibility genes in complex ...
Jessica Cheng, Joshua S. Clayton, Joshua S. Clayton, Rafael D. Acemel, Ye Zheng, Ye Zheng, Rhonda L. Taylor, Rhonda L. Taylor, Sündüz Keleş, Sündüz Keleş, Martin Franke, Susan A. Boackle, Susan A. Boackle, John B. Harley, John B. Harley, John B. Harley, Elizabeth Quail, Elizabeth Quail, José Luis Gómez-Skarmeta, Daniela Ulgiati   +19 more
doaj   +1 more source

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

A method of predicting changes in human gene splicing induced by genetic variants in context of cis-acting elements [PDF]

, 2010
Background: polymorphic variants and mutations disrupting canonical splicing isoforms are among the leading causes of human hereditary disorders. While there is a substantial evidence of aberrant splicing causing Mendelian diseases, the implication of ...
Churbanov, Alexander, Hicks, Chindo, Churbanov Alexander, Chindo Hicks, Vorechovsky, Igor, Vořechovský Igor, Hicks Chindo, Igor Vořechovský, Alexander Churbanov   +8 more
core   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

A transcribed enhancer dictates mesendoderm specification in pluripotency [PDF]

, 2017
Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage specification during development. Here, we evaluate remodeling of the enhancer landscape and modulation of the lncRNA transcriptome during mesendoderm specification.
Marco Mina, Ibberson, M., Plaisance, Isabelle, Ounzain, S., Leib, S.L., Burdet, Frédéric, Kernen, Jasmin, Alexanian, Michael, Maric, D., Friedman, C.E., Nemir, Mohamed, Jenkinson, S.P., Micheletti, R., Alexanian, M., Villeneuve, D., Villeneuve, Dominic, Pedrazzini, T., Ching-Chia Ting, Damien Maison, Thierry Pedrazzini, Nemir, M., Mina, M., Clayton E. Friedman, Iole Pezzuto, Ounzain, Samir, Hernandez, Nouria, Stephen P. Jenkinson, Maric, Daniel, Daniel Maric, Maison, D., Kernen, J., Ting, Ching-Chia, Mark Ibberson, Pedrazzini, Thierry, Nathan J. Palpant, Burdet, F., Plaisance, I., Pezzuto, Iole, Pezzuto, I., Stephen L. Leib, Nouria Hernandez, Maison, Damien, Leib, Stephen, Mohamed Nemir, Frédéric Burdet, Mina, Marco, Ibberson, Mark, Ting, C.C., Samir Ounzain, Rudi Micheletti, Jasmin Kernen, Palpant, Nathan J., Jenkinson, Stephen Philip, Micheletti, Rudi, Isabelle Plaisance, Dominic Villeneuve, Palpant, N.J., Michael Alexanian, Friedman, Clayton E., Hernandez, N.   +59 more
core   +1 more source

Dynamic chromatin architectures provide insights into the genetics of cattle myogenesis

Journal of Animal Science and Biotechnology, 2023
Background Sharply increased beef consumption is propelling the genetic improvement projects of beef cattle in China. Three-dimensional genome structure is confirmed to be an important layer of transcription regulation.
Jie Cheng, Xiukai Cao, Xiaogang Wang, Jian Wang, Binglin Yue, Wei Sun, Yongzhen Huang, Xianyong Lan, Gang Ren, Chuzhao Lei, Hong Chen   +10 more
doaj   +1 more source