Results 41 to 50 of about 4,995,766 (296)

Genomic Approaches Uncover Increasing Complexities in the Regulatory Landscape at the Human SCL (TAL1) Locus [PDF]

, 2010
The SCL (TAL1) transcription factor is a critical regulator of haematopoiesis and its expression is tightly controlled by multiple cis-acting regulatory elements.
Kelly Chiang, Bonhoure, N, Andrews, RM, Shane C Dillon, Dillon, SC, Alexander W Bruce, Jim, J.H., Cordelia Langford, Jonathan L Cooper, Vetrie, D., Bonhoure, N., Bruce, A.W., Robert M Andrews, Johanna H Jim, Chiang, K, Dillon, S.C., Cooper, J.L., Peter D Ellis, Chiang, K., Vetrie, D, Amanda Hall, Cooper, JL, Bruce, AW, Nicolas Bonhoure, Ellis, P.D., Dhami, P., Dhami, P, Langford, C., Andrews, R.M., Jim, JH, Ellis, PD, David Vetrie, Langford, C, Hall, A., Pawandeep Dhami, Hall, A   +35 more
core   +1 more source

Optimised plasmids for sustained transgene expression in vivo [PDF]

, 2010
Plasmid based gene therapy approaches often lack long term transgene expression in vivo due to silencing or loss of the vector. One way to overcome these limitations is to combine non-silenced promoters with strong viral enhancers.
Magnusson, Terese
core   +1 more source

Androgen Receptor-Mediated Transcription in Prostate Cancer

Cells, 2022
Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate cancer (PCa) growth and differentiation. This process involves a complex interplay of coregulatory proteins, chromatin remodeling complexes, and other ...
Doğancan Özturan, Tunç Morova, Nathan A. Lack   +2 more
doaj   +1 more source

PEACOCK: a machine learning approach to assess the validity of cell type-specific enhancer-gene regulatory relationships

npj Systems Biology and Applications, 2023
The vast majority of disease-associated variants identified in genome-wide association studies map to enhancers, powerful regulatory elements which orchestrate the recruitment of transcriptional complexes to their target genes’ promoters to upregulate ...
Caitlin Mills, Crystal N. Marconett, Juan Pablo Lewinger, Huaiyu Mi   +3 more
doaj   +1 more source

Genetic properties and chromatin structure of the yeast gal regulatory element: an enhancer-like sequence. [PDF]

Proceedings of the National Academy of Sciences, 1984
DNA molecules created by fusing a 365-base-pair segment of yeast DNA encoding the galactose-regulated upstream promoter element (gal) to a set of derivatives that systematically delete sequences upstream from the his3 gene are introduced in single copy back into the yeast genome precisely at the his3 locus and then assayed for transcription. Fusions of
openaire   +2 more sources

Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism

Cell Reports, 2018
Summary: Transcriptional dysregulation of the MYC oncogene is among the most frequent events in aggressive tumor cells, and this is generally accomplished by acquisition of a super-enhancer somewhere within the 2.8 Mb TAD where MYC resides.
Jurian Schuijers, John Colonnese Manteiga, Abraham Selby Weintraub, Daniel Sindt Day, Alicia Viridiana Zamudio, Denes Hnisz, Tong Ihn Lee, Richard Allen Young   +7 more
doaj   +1 more source

Enhancer requirement for murine cytomegalovirus growth and genetic complementation by the human cytomegalovirus enhancer [PDF]

, 1998
The cytomegalovirus (CMV) enhancer is a highly complex regulatory region containing multiple elements that interact with a variety of host-encoded transcription factors. Many of these sequence elements are conserved among the different species strains of
Angulo, A, Koszinowski, U H, Messerle, M, Ghazal, P   +3 more
core   +2 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Regulatory Architecture of the RCA Gene Cluster Captures an Intragenic TAD Boundary, CTCF-Mediated Chromatin Looping and a Long-Range Intergenic Enhancer

Frontiers in Immunology, 2022
The Regulators of Complement Activation (RCA) gene cluster comprises several tandemly arranged genes with shared functions within the immune system. RCA members, such as complement receptor 2 (CR2), are well-established susceptibility genes in complex ...
Jessica Cheng, Joshua S. Clayton, Joshua S. Clayton, Rafael D. Acemel, Ye Zheng, Ye Zheng, Rhonda L. Taylor, Rhonda L. Taylor, Sündüz Keleş, Sündüz Keleş, Martin Franke, Susan A. Boackle, Susan A. Boackle, John B. Harley, John B. Harley, John B. Harley, Elizabeth Quail, Elizabeth Quail, José Luis Gómez-Skarmeta, Daniela Ulgiati   +19 more
doaj   +1 more source

VEZF1 elements mediate protection from DNA methylation [PDF]

, 2010
There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
Gowher Humaira, Hair, Alan, Miklos Gaszner, West Adam G., Gary Felsenfeld, Jacqueline Dickson, Dickson Jacqueline, Strogantsev, Ruslan, Gaszner Miklos, Dickson, Jacqueline, Adam G West, Humaira Gowher, Gaszner, Miklos, West, Adam G, Gowher, Humaira, West, Adam G., Felsenfeld Gary, Ruslan Strogantsev, Strogantsev Ruslan, Hair Alan, Felsenfeld, Gary, Alan Hair   +21 more
core   +2 more sources