Results 51 to 60 of about 4,995,766 (296)

Post-Zygotic and Inter-Individual Structural Genetic Variation in a Presumptive Enhancer Element of the Locus between the IL10Rβ and IFNAR1 Genes

PLoS ONE, 2013
Although historically considered as junk-DNA, tandemly repeated sequence motifs can affect human phenotype. For example, variable number tandem repeats (VNTR) with embedded enhancers have been shown to regulate gene transcription. The post-zygotic variation is the presence of genetically distinct populations of cells in an individual derived from a ...
Razzaghian HR, Forsberg LA, Prakash KR, Przerada S, Paprocka H, Zywicka A, Westerman MP, Pedersen NL, O'Hanlon TP, Rider LG, Miller FW, Srutek E, Jankowski M, Zegarski W, Piotrowski A, Absher D, Dumanski JP   +16 more
openaire   +6 more sources

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Discovering human transcription factor physical interactions with genetic variants, novel DNA motifs, and repetitive elements using enhanced yeast one-hybrid assays [PDF]

Genome Research, 2019
Identifying transcription factor (TF) binding to noncoding variants, uncharacterized DNA motifs, and repetitive genomic elements has been technically and computationally challenging. Current experimental methods, such as chromatin immunoprecipitation, generally test one TF at a time, and computational motif algorithms often lead to
Shrestha, Shaleen, Sewell, Jared Allan, Santoso, Clarissa Stephanie, Forchielli, Elena, Carrasco Pro, Sebastian, Martinez, Melissa, Fuxman Bass, Juan Ignacio   +6 more
openaire   +4 more sources

Technical and biological sources of noise confound multiplexed enhancer AAV screening

Nature Communications
Cis-acting regulatory enhancer elements are powerful tools for achieving cell type-specific genetic access in adeno-associated virus (AAV) delivery platforms.
Avery C. Hunker, John K. Mich, Naz Taskin, Amy Torkelson, Trangthanh Cardenas, Jean-Benoît Lalanne, Joseph T. Mahoney, Darren Bertagnolli, Anish Bhaswanth Chakka, Rushil Chakrabarty, Nicholas P. Donadio, Rebecca Ferrer, Molly Gasperini, Jeff Goldy, Junitta Guzman, Kelly Jin, Shannon Khem, Rana Kutsal, Refugio A. Martinez, Dakota Newman, Nick Pena, Christine Rimorin, Dana Rocha, Nadiya V. Shapovalova, Michael Tieu, Natalie Weed, Thomas Zhou, Rebecca Hodge, Shenqin Yao, Jay Shendure, Kimberly A. Smith, Ed S. Lein, Bosiljka Tasic, Boaz P. Levi, Jonathan T. Ting   +34 more
doaj   +1 more source

NUBIScan, an in silico approach for prediction of nuclear receptor response elements [PDF]

, 2002
Nuclear receptors (NRs) are transcription factors activated by a multitude of hormones, other endogenous substances, and exogenous molecules. These proteins modulate the regulation of target genes by contacting their promoter or enhancer sequences at ...
Kaufmann, M. R., Handschin, C., Meyer, U. A., Podvinec, M., Meyer UA, Kaufmann MR, Handschin C, Podvinec M   +7 more
core   +1 more source

Analysis of Estrogen Response Element Binding by Genetically Selected Steroid Receptor DNA Binding Domain Mutants Exhibiting Altered Specificity and Enhanced Affinity [PDF]

Journal of Biological Chemistry, 1999
To analyze the role of amino acids in the steroid receptor DNA binding domain (DBD) recognition helix in binding of the receptor to the estrogen response element (ERE), we adapted the powerful P22 challenge phage selection system for use with a vertebrate protein. We used the progesterone receptor DNA binding domain and selected for mutants that gained
S, Chusacultanachai, K A, Glenn, A O, Rodriguez, E K, Read, J F, Gardner, B S, Katzenellenbogen, D J, Shapiro   +6 more
openaire   +2 more sources

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom, Dorella Scarponi, Giulia Zucchetti, Teresa Perillo, Maria Montanaro, Elisa Marconi, Chiara Rutigliano, Paolo Colavero, Paola Quarello, Marina Bertolotti, Monica Cellini, Carlo Clerici, Maurizio Mascarin, Francesca Bomben, Andrea Ferrari, the expert workgroup   +15 more
wiley   +1 more source

Supplementary Data from Genetic, Pharmacogenomic, and Immune Landscapes of Enhancer RNAs Across Human Cancers

, 2022
Supplementary Data from Genetic, Pharmacogenomic, and Immune Landscapes of Enhancer RNAs Across Human ...
Charles Lussier (14956153), Zhao Zhang (52732), Yuan Liu (88411), Qiang Li (8118), Leng Han (9018434), An-Yuan Guo (14956156), Youqiong Ye (5945879), Mei Luo (773169), Jian Zhang (1682)   +8 more
core   +2 more sources

Determinants of enhancer and promoter activities of regulatory elements

, 2020
The proper activities of enhancers and gene promoters are essential for coordinated transcription within a cell. Although diverse methodologies have been developed to identify enhancers and promoters, most have tacitly assumed that these elements are ...
Albin Sandelin, Sandelin, Albin, Robin Andersson, Andersson, Robin   +3 more
core   +1 more source

A transcribed enhancer dictates mesendoderm specification in pluripotency [PDF]

, 2017
Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage specification during development. Here, we evaluate remodeling of the enhancer landscape and modulation of the lncRNA transcriptome during mesendoderm specification.
Marco Mina, Ibberson, M., Plaisance, Isabelle, Ounzain, S., Leib, S.L., Burdet, Frédéric, Kernen, Jasmin, Alexanian, Michael, Maric, D., Friedman, C.E., Nemir, Mohamed, Jenkinson, S.P., Micheletti, R., Alexanian, M., Villeneuve, D., Villeneuve, Dominic, Pedrazzini, T., Ching-Chia Ting, Damien Maison, Thierry Pedrazzini, Nemir, M., Mina, M., Clayton E. Friedman, Iole Pezzuto, Ounzain, Samir, Hernandez, Nouria, Stephen P. Jenkinson, Maric, Daniel, Daniel Maric, Maison, D., Kernen, J., Ting, Ching-Chia, Mark Ibberson, Pedrazzini, Thierry, Nathan J. Palpant, Burdet, F., Plaisance, I., Pezzuto, Iole, Pezzuto, I., Stephen L. Leib, Nouria Hernandez, Maison, Damien, Leib, Stephen, Mohamed Nemir, Frédéric Burdet, Mina, Marco, Ibberson, Mark, Ting, C.C., Samir Ounzain, Rudi Micheletti, Jasmin Kernen, Palpant, Nathan J., Jenkinson, Stephen Philip, Micheletti, Rudi, Isabelle Plaisance, Dominic Villeneuve, Palpant, N.J., Michael Alexanian, Friedman, Clayton E., Hernandez, N., Burdet F, Maison D, Pezzuto I, Villeneuve D, Pedrazzini T, Mina M, Nemir M, Maric D, Micheletti R, Ting CC, Palpant NJ, Plaisance I, Ounzain S, Friedman CE, Kernen J, Leib SL, Hernandez N, Ibberson M, Alexanian M, Jenkinson SP   +79 more
core   +2 more sources