Results 91 to 100 of about 6,250,950 (265)
, 2009 Acknowledgements -- Introduction -- Human enhancement ethics: the state of the debate / Nick Bostrom and Julian Savulescu -- Pt. I. Human enhancement in general -- 1. Can anyone really be talking about ethically modifying human nature?
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Accuracy Enhancement of Automated System for Multicomponent Batching of Bulk Materials
MATEC Web of Conferences, 2015 In the paper the choice of reasonable structure of automated system for multicomponent batching of bulk materials has been substantiated to minimize the batching error of about 3% in case the recipe mixture includes small components of big importance in ...
Bukreev V.G. +2 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Watershed restoration inventory
, 1998 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.1998-Mode of access: Internet from the Oregon Government ...
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
MEDICAL ENHANCEMENT AND POSTHUMANITY
, 2009 Introduction / Bert Gordijn and Ruth Chadwick -- Pt. I. Medical enhancement -- 1. The history of medical enhancement: from Restitutio ad Integrum to Transformatio ad Optimum? / Urban Wiesing -- 2. Therapy, enhancement and improvement / Ruth Chadwick --
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Oregon Watershed Enhancement Board
, 2017 Title from PDF caption (viewed on November 23, 2022).Covers OCLC #1351607912 and OCLC #1066116055.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and
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Submicron structure random field on granular soil material with retinex algorithm optimization
EPJ Web of Conferences, 2017 In this paper, a Retinex scale optimized image enhancement algorithm is proposed, which can enhance the micro vision image and eliminate the influence of the uneven illumination.
Liang Yu +4 more
doaj +1 more source