Results 111 to 120 of about 6,250,950 (265)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Oregon Watershed Enhancement Board small grant areas
, 2007 Title from PDF caption (viewed on July 6, 2022)."OWEB- A. Seim, November 2007."No relief shownIncludes legend.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Patron-Driven Expedited Cataloging Enhancement to WebPAC Pro
Code4Lib Journal, 2012 This article outlines the development of an integrated patron-driven expedited cataloging feature in the catalog of the Connecticut State University Library System (CONSULS).
Steven Jay Bernstein
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
HUMANITY'S END: WHY WE SHOULD REJECT RADICAL ENHANCEMENT
, 2010 Acknowledgments -- 1. What is radical enhancement? -- 2. Radical enhancement and posthumanity -- 3. The technologist: Ray Kurzweil and the law of accelerating returns -- 4. Is uploading ourselves into machines a good bet? -- 5. The therapist: Aubrey
Agar, Nicholas
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
An Investigation to Determine an Optimum Protective Garment Material in Nuclear Medicine
Journal of Biomedical Physics and Engineering, 2018 Aim: The aim of this study is to find an optimum material to protect garment for protection against 99Tcm radionuclide. Materials and Methods: Monte Carlo simulation code was applied to investigate radiation attenuation of 13 shielding materials ...
R Parvaresh +5 more
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