Results 161 to 170 of about 8,934,200 (403)
A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
Nature Communications, 2018 Temozolomide (TMZ) was used for the treatment of glioblastoma (GBM) for over a decade, but its treatment benefits are limited by acquired resistance, a process that remains incompletely understood.
Xiaoyue Chen +13 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source
CERTAIN CONDITIONS DETERMINING ENHANCED INFECTION WITH THE RABBIT PAPILLOMA VIRUS [PDF]
, 1944 William F. Friedewald
openalex +1 more source
Genes & Development, 2018 This review by Catarino and Stark discusses recent insights into mechanistic aspects of enhancer functions. It covers recent developments in the prediction of enhancers based on chromatin characteristics and their identification by functional reporter ...
Rui R Catarino, A. Stark
semanticscholar +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
EMBO Molecular Medicine, 2016 Cancer is a disease of the genome caused by oncogene activation and tumor suppressor gene inhibition. Deep sequencing studies including large consortia such as TCGA and ICGC identified numerous tumor‐specific mutations not only in protein‐coding ...
Sven Diederichs +22 more
doaj +1 more source
LXXI. On the general problem of photographic reproduction, with suggestions for enhancing gradation originally invisible [PDF]
, 1911 Lord Rayleigh
openalex +1 more source
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
FEBS Letters, EarlyView.In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász +6 more
wiley +1 more source
Meta-analysis of massively parallel reporter assays enables prediction of regulatory function across cell types. [PDF]
, 2019 Deciphering the potential of noncoding loci to influence gene regulation has been the subject of intense research, with important implications in understanding genetic underpinnings of human diseases.
Ahituv, Nadav +3 more
core