Results 171 to 180 of about 9,293,313 (313)

Molecular determinants of AR-enhancer interaction and cistrome reprogramming in prostate cancer progression. [PDF]

Endocr Relat Cancer
Fernandes RC, Greenland KK, Campbell MJ, Bevan CL.   +3 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Regulatory logic underlying neural crest contributions to the head versus the heart. [PDF]

Proc Natl Acad Sci U S A
Gandhi S, Rajan ARD, Urrutia H, Wilson JS, Ling ITC, Williams R, Sauka-Spengler T, Bronner ME.   +7 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Genome reorganization and its functional impact during breast cancer progression. [PDF]

Elife
Reed KSM, Fritz A, Greenyer H, Heselmeyer-Haddad K, Frietze S, Stein J, Stein G, Misteli T.   +7 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A Transcription Factor-Centric View of Transcription Regulation. [PDF]

Biology (Basel)
He J, Chi J, Feng S.
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Splashed E-box and AP-1 motifs cooperatively drive regeneration response and shape regeneration abilities

Biology Open, 2023
Teruhisa Tamaki, Takafumi Yoshida, Eri Shibata, Hidenori Nishihara, Haruki Ochi, Atsushi Kawakami   +5 more
doaj   +1 more source

Regulatory changes underlying the evolution of skylight navigation. [PDF]

iScience
Roth H, Sarfert M, Simdianova A, Balke J, Perry MW, Nowick K, Wernet MF.   +6 more
europepmc   +1 more source