Results 221 to 230 of about 9,920,783 (328)

SPATIO-TEMPORAL ORGANIZATION OF THE SUPER-ENHANCER STRUCTURE IN CANCER CELLS

European Journal of Histochemistry
Our research investigates the spatiotemporal organization of nuclear architecture via biomolecular condensation, focusing on the role of liquid–liquid phase separation (LLPS) in gene regulation during cancer progression. We identify phosphatidylinositol
doaj   +1 more source

Enhancer RNA-mediated transcriptional regulatory programs reveal the malignant progression of glioma. [PDF]

Sci Adv
Ma Y, Wang S, Jia Y, Wang S, Liu W, Yu J, Wang J, Geng J, Zhao J, Zhao Z, Xu J, Liu H.   +11 more
europepmc   +1 more source

GAS1RR, an immune-related enhancer RNA, is related to biochemical recurrence-free survival in prostate cancer. [PDF]

Exp Biol Med (Maywood), 2023
Xiong Z, Ge Y, Xiao J, Wang Y, Li L, Ma S, Lan L, Liu B, Qin B, Luan Y, Yang C, Ye Z, Wang Z.   +12 more
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Biological roles of enhancer RNA m6A modification and its implications in cancer. [PDF]

Cell Commun Signal
Han Y, Sun J, Yao M, Miao L, Li M.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

RNA polymerase II dynamics shape enhancer–promoter interactions

Nature Genetics, 2023
Gilad Barshad, James J. Lewis, Alexandra G. Chivu, Abderhman Abuhashem, Nils Krietenstein, E. Rice, Yitian Ma, Zhong Wang, O. Rando, A. Hadjantonakis, C. Danko   +10 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Enhancer RNA transcription pinpoints functional genetic variants linked to asthma. [PDF]

Nat Commun
Sasse SK, Dahlin A, Sanford L, Gruca MA, Gupta A, Gally F, Wu AC, Iribarren C, Dowell RD, Weiss ST, Gerber AN.   +10 more
europepmc   +1 more source