Results 301 to 310 of about 9,920,783 (328)

Enhancer RNAs

2017
Targeted mutagenesis is required to evaluate the function of DNA segments across the genome. In recent years the CRISPR/Cas9 technology has been widely used for functional genome studies and is partially replacing classical homologous recombination methods in different aspects.
Andrey Guillaume, Spielmann Malte
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Enhancing the RNA engineering toolkit

Science, 2017
The CRISPR-Cas13 system can be used to engineer ...
Li, Yang, Ling-Ling, Chen
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Enhancing Diagnosis Through RNA Sequencing

Clinics in Laboratory Medicine, 2020
The diagnostic rate of comprehensive genomic sequencing remains only 25% to 30% due to the difficulty in interpreting variants of uncertain significance and noncoding mutations and in elucidating downstream effects of these and other genetic changes. Unlike DNA sequencing, RNA sequencing (RNAseq) reveals the functional consequence of genetic variation ...
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Enhancer-associated RNAs as therapeutic targets

Expert Opinion on Biological Therapy, 2015
Regulation of gene expression involves a variety of mechanisms driven by a complex regulatory network of factors. Control of transcription is an important step in gene expression regulation, which integrates the function of cis-acting and trans-acting elements.
Nicolas Léveillé, Carlos A Melo, Reuven Agami   +2 more
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Enhanced RNA binding of dimerized aminoglycosides

Bioorganic & Medicinal Chemistry, 1999
Aminoglycoside antibiotics have recently emerged as an intriguing family of RNA binding molecules and they became leading structures for the design of novel RNA ligands. The demystification of the aminoglycoside-RNA recognition phenomenon is required for the development of superior binders.
K, Michael, H, Wang, Y, Tor
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Visualization of Enhancer-Derived Noncoding RNA

2016
Enhancers are principal regulators that allow spatiotemporal tissue-specific control of gene expression. While mounting evidence suggests that enhancer-derived long noncoding RNAs (long ncRNAs), including enhancer RNAs (eRNAs), are an important component of enhancer function, their expression has not been broadly analyzed at a single cell level via ...
Youtaro, Shibayama, Stephanie, Fanucchi, Musa M, Mhlanga   +2 more
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RNA Interference Enhanced Implants

2011
RNA interference (RNAi) has in the last decade seen ever increasing use in cell biology as both a tool with which most cell functions can be modulated and as a natural mechanism through which cells regulate their gene expression. As RNAi can be used to direct stem cell differentiation, enhance tissue development, modulate inflammation and control other
Morten Østergaard Andersen, Jørgen Kjems   +1 more
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Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation

Biochemical and Biophysical Research Communications, 2008
Nkx2.2AS is an endogenous antisense transcript to Nkx2.2 gene, subcellularly located in the cytoplasm. We tested if Nkx2.2AS transcripts have any biological function by regulating transcription level of Nkx2.2 coding gene in the differentiation of neural stem cells.
Shiro, Tochitani, Yoshihide, Hayashizaki
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Magnesium Pemoline: Enhancement of Brain RNA Polymerases

Science, 1966
The stimulation by magnesium pemoline of systems that synthesize brain nucleic acid was studied in vivo and in vitro. There are differential effects between true RNA polymerase and pseudo-RNA polymerase. The selective stimulation of true RNA polymerase by magnesium pemoline was not observed with stimulants of the central nervous system and psychotropic
A J, Glasky, L N, Simon
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Enhancer RNAs: a class of long noncoding RNAs synthesized at enhancers.

Cold Spring Harbor perspectives in biology, 2015
Recent studies have revealed that active enhancers are transcribed, producing a class of noncoding RNAs called enhancer RNAs (eRNAs). eRNAs are distinct from long noncoding RNAs (lncRNAs), but these two species of noncoding RNAs may share a similar role in the activation of mRNA transcription.
Tae-Kyung, Kim, Martin, Hemberg, Jesse M, Gray   +2 more
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