Results 231 to 240 of about 34,698 (281)
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The assay of Met-enkephalin aminopeptidase with [125I]Met-enkephalin
Journal of Biochemical and Biophysical Methods, 1982Presented here are procedural modifications which permit the utilization of 125I-labeled Met-enkephalin as substrate in the assay of rat brain enkephalin aminopeptidase. Th hydrolysis of enkephalin is monitored by the release of [125I]tyrosine separated on Porapak Q.
James L. Caffrey, Donald H. Hodges
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Rapid separation of enkephalins and endorphins on Sep-Pak reverse phase cartridges.
International journal of peptide & protein research, 2009A simple, rapid method is described for separating neuropeptides. Samples were injected on Sep-Pak disposable reverse phase cartridges and eluted with a step gradient of n-propanol in formate-pyridine buffer.
R. Lahti
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Synthesis of phosphonic analogs of enkephalins. Pentapeptides with COOH replaced by PO3H2 group.
International journal of peptide & protein research, 2009Eight analogs of enkephalins containing the phosphonic analogs of Gly, Leu, Met, Phe and Pro have been synthesized by standard procedures in solution.
L. Kupczyk-subotkowska, P. Mastalerz
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Synthesis and biological activity of △Phe4-enkephalins
, 2009The ΔPhe4-enkephalins have been synthesized and examined in an in vitro receptor binding assay and an in vivo tail flick analgesia test. The ΔPhe4 residue was derived from Boc-Gly-Phe(β-OH)-OH by spontaneous dehydration and azlactonization. The dipeptide
Y. Shimohigashi +3 more
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Enkephalin-containing polypeptides are potent inhibitors of enkephalin degradation
Peptides, 1983Enkephalin-containing polypeptides derived from pro-enkephalin A, pro-enkephalin B, or pro-opiomelanocortin were inhibitors of enkephalin degradation by aminoenkephalinases purified from cytosol or membranes. Of the peptides, Argo-Met-enkephalin was the most potent inhibitor for the aminoenkephalinases, with an IC50 of about 0.6 microM, it was more ...
Nicholas Ling +5 more
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Enkephalin Release and Enkephalin-Precursors in Chicken Retina [PDF]
, 1989 The demonstration of enkephalin-like immunoreactive neurons (Brecha, et al., 1979), opiate receptors (Osborne and Hertz, 1981; Slaughter, et al., 1985) and opiate-affected ganglion cell responses (Djamgoz, et al., 1981; Dick and Miller, 1981) favour the acceptance of an opiate-transmitter system in vertebrate retina.
Mark Dowton +2 more
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Enkephalins and nigrostriatal function
Neurology, 1978Unilateral lesions of the substantia nigra were made with 6-hydroxydopamine in rats. In this model, drugs such as naloxone, which block endogenous enkephalin receptors, potentiated agents with postsynaptic dopaminergic actions, while antagonizing agents with presynaptic dopaminergic actions.
Richard L. Borison, Bruce I. Diamond
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Spontaneous inactivation of enkephalin
Biochemical and Biophysical Research Communications, 1978Summary Dilute solutions of enkephalin are not stable upon prolonged storage. A new peak of UV absorption (at 325 nm) gradually appears. This change in spectral properties is accompanied by an alteration in the chromatographic pattern as well as the spontaneous modification of the tyrosyl residue of the enkephalin molecule.
Talia Miron +3 more
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European Journal of Pharmacology, 1980
Morphine is known to produce mydriasis in mice. We have found that enkephalins caused a similar effect. Morphine was twice as active as D-Ala-D-Leu-enkephalin (BW-180C), 5 times as active as Met-enkephalin and 7 times as active as Leu-enkephalin. The time course of the effect was shortest for the enkephalins ( t 1/2 = 8-12 min), intermediate for BW ...
Yechiel Eshel +2 more
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Morphine is known to produce mydriasis in mice. We have found that enkephalins caused a similar effect. Morphine was twice as active as D-Ala-D-Leu-enkephalin (BW-180C), 5 times as active as Met-enkephalin and 7 times as active as Leu-enkephalin. The time course of the effect was shortest for the enkephalins ( t 1/2 = 8-12 min), intermediate for BW ...
Yechiel Eshel +2 more
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Blood-brain barrier restriction of peptides and the low uptake of enkephalins.
Endocrinology, 1978Blood-brain barrier penetration of leucine-enkephalin, methionine-enkephalin, and other peptide-like compounds was measured after intracarotid injection of three isotopes and was found to be non-saturable over the nanomolar range of concentrations tested.
E. Cornford +3 more
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