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Enkephalin in the goldfish retina [PDF]
Cellular and Molecular Neurobiology, 1986 Enkephalin-like immunoreactive amacrine cells were visualized using the highly sensitive avidin-biotin method. The somas of these cells were situated in the inner nuclear and ganglion cell layers. Enkephalin-stained processes were observed in layers 1, 3, and 5 of the inner plexiform layer.
C.B. Watt +3 more
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On the Origin of Leu-Enkephalin and Met-Enkephalin in the Rat Neurohypophysis
Endocrinology, 1985The posterior lobe of the pituitary contains large amounts of Leu- and Met-enkephalin (LE and ME, respectively). A marked depletion of ME (81.9%) and LE (94.5%) in the posterior pituitary occurred after transection of the pituitary stalk. This indicates that most, if not all, of the enkephalins are in processes of central neurons. In the present study,
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Science, 1978
The intraventricular injection of methionine-enkephalin (50 to 100 micrograms) or [d-Ala2]-methionine-enkephalinamide (1.5 to 12 micrograms), a synthetic enkephalin analog resistant to enzyme degradation, caused a marked dose-dependent increase in ...
G. Biggio +4 more
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The intraventricular injection of methionine-enkephalin (50 to 100 micrograms) or [d-Ala2]-methionine-enkephalinamide (1.5 to 12 micrograms), a synthetic enkephalin analog resistant to enzyme degradation, caused a marked dose-dependent increase in ...
G. Biggio +4 more
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1990
Morphine, an opium alkaloid derived from the poppy, Papaver somniferum, has been one of the most commonly used analgesics in both clinical and experimental fields despite its addictive properties. In 1975, after a specific opiate receptor had been demonstrated, two endogenous opioid peptides, methionine enkephalin (Met-enk) and leucine enkephalin (Leu ...
Teruo Kudo, Reizo Inoki
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Morphine, an opium alkaloid derived from the poppy, Papaver somniferum, has been one of the most commonly used analgesics in both clinical and experimental fields despite its addictive properties. In 1975, after a specific opiate receptor had been demonstrated, two endogenous opioid peptides, methionine enkephalin (Met-enk) and leucine enkephalin (Leu ...
Teruo Kudo, Reizo Inoki
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Potent tetrapeptide enkephalins
Life Sciences, 1981Abstract Small peptides with opiate-like activity have generally had structures closely resembling that of the opioid pentapeptide enkephalin: Tyr-Gly-Gly-Phe-Met-COOH. Single deletions of any one of the amino acids has been demonstrated to reduce opiate activity drastically.
Richard E. Chipkin +6 more
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2016
Enkephalins are endogenous opioid pentapeptides that are produced mainly in the central nervous system, adrenal medulla, and other peripheral tissues. There are two structurally different enkephalin peptides: Met-enkephalin (YGGFM), and Leu-enkephalin (YGGFL).
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Enkephalins are endogenous opioid pentapeptides that are produced mainly in the central nervous system, adrenal medulla, and other peripheral tissues. There are two structurally different enkephalin peptides: Met-enkephalin (YGGFM), and Leu-enkephalin (YGGFL).
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Clinical and Experimental Pharmacology and Physiology, 1989
SUMMARY1. A radio‐immunoassay (RIA) for methionine‐enkephalin sulfoxide was developed and was used to measure methionine‐enkephalin, after oxidation, in the rat brain.2. The RIA was performed together with assays that use commercially available met‐and leu‐enkephalin antisera.3.
George K. L. Tiong, Jean E. Olley
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SUMMARY1. A radio‐immunoassay (RIA) for methionine‐enkephalin sulfoxide was developed and was used to measure methionine‐enkephalin, after oxidation, in the rat brain.2. The RIA was performed together with assays that use commercially available met‐and leu‐enkephalin antisera.3.
George K. L. Tiong, Jean E. Olley
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The metabolic stability of the enkephalins
Biochemical and Biophysical Research Communications, 1977Abstract [Met 5 ] and [Leu 5 ]-enkephalins inhibit 3 H-naloxone binding to brain opiate receptors much more effectively at 4°C than at 25°C. At 25°C several protease inhibitors potentiate the action of the enkephalins. Bacitracin is the most effective of these.
Kwen-Jen Chang +3 more
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Peptides, 1984
Immunohistochemical localization of Met-enkephalin, Met-enkephalin-Arg6-Gly7-Leu8, Met-enkephalin-Arg6-Phe7 and Leu-enkephalin was studied in human adrenal medulla and pheochromocytomas at the light and electron microscopic levels. Both adrenal medulla and pheochromocytomas (4 adrenal, 1 extra-adrenal) showed scattered or clustered cells which ...
Keiichi Watanabe +4 more
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Immunohistochemical localization of Met-enkephalin, Met-enkephalin-Arg6-Gly7-Leu8, Met-enkephalin-Arg6-Phe7 and Leu-enkephalin was studied in human adrenal medulla and pheochromocytomas at the light and electron microscopic levels. Both adrenal medulla and pheochromocytomas (4 adrenal, 1 extra-adrenal) showed scattered or clustered cells which ...
Keiichi Watanabe +4 more
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2000
Enkephalin analogs for multivalent ligand systems, bivalent enkephalins, multivalent enkephalins on polymers, multivalent ligands on vesicles, simultaneous activation of two different receptor systems, and cell interactions of enkephalin/polypeptide conjugates are described.
Shunsaku Kimura, Yukio Imanishi
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Enkephalin analogs for multivalent ligand systems, bivalent enkephalins, multivalent enkephalins on polymers, multivalent ligands on vesicles, simultaneous activation of two different receptor systems, and cell interactions of enkephalin/polypeptide conjugates are described.
Shunsaku Kimura, Yukio Imanishi
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