Results 251 to 260 of about 17,087 (287)
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Biosynthesis of the Enkephalins and Enkephalin-Containing Polypeptides
Annual Review of Pharmacology and Toxicology, 1983The biochemical characterization of the enkephalins and the enkephalin-containing polypeptides and their biosynthesis has reached an advanced state. From the structural data showing great similarities between human and beef proenkephalin there is strong evidence for physiological roles for some of the extended enkephalins and for at least two of the ...
Alvin S. Stern, Randolph V. Lewis
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Biochemistry of the enkephalins and enkephalin-containing peptides
Archives of Biochemistry and Biophysics, 1983The enkephalins are present in many tissues not only as the free pentapeptides, but also as internal sequences in larger polypeptides of varying size. Fourteen enkephalin-containing peptides (EC peptides) from beef adrenal medulla were isolated and sequenced, and the presence of a protein that contained several [Met]enkephalin sequences and one of [Leu]
Sidney Udenfriend, Daniel L. Kilpatrick
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Enkephalins as immunomodulators
International Journal of Immunopharmacology, 1983The protective effects of methionine enkephalin as well as leucine enkephalin were studied in BDF1 mice inoculated with 1 X 10(4) and 1 X 10(2) cells of L1210 murine leukemia. Significant increases in number of survivors were observed in mice treated with enkephalins.
N. P. Plotnikoff, Gerald C. Miller
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Life Sciences, 1983
Methionine-enkephalin(met-enkephalin)-, leucine-enkephalin(leu-enkephalin)-, methionine-enkephalin-Arg6-Phe7(met-enkephalin-Arg-Phe)- and methionine-enkephalin-Arg6-Gly7-Leu8(met-enkephalin-Arg-Gly-Leu)-like immunoreactivities(-LI) were studied in 16 pheochromocytomas by radioimmunoassays (RIAs) for these four opioid peptides. Met-enkephalin-Arg-Phe-LI
Yoshio Ikeda +5 more
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Methionine-enkephalin(met-enkephalin)-, leucine-enkephalin(leu-enkephalin)-, methionine-enkephalin-Arg6-Phe7(met-enkephalin-Arg-Phe)- and methionine-enkephalin-Arg6-Gly7-Leu8(met-enkephalin-Arg-Gly-Leu)-like immunoreactivities(-LI) were studied in 16 pheochromocytomas by radioimmunoassays (RIAs) for these four opioid peptides. Met-enkephalin-Arg-Phe-LI
Yoshio Ikeda +5 more
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1979
Publisher Summary This chapter discusses the identification and distribution of enkephalins and endorphins. The two main methods of detecting and quantitating enkephalins and endorphins used so far are radioimmunoassay and bioassay. In addition, opioid receptor binding assays were originally utilized to detect general opioid activity.
Richard J. Miller, Pedro Cuatrecasas
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Publisher Summary This chapter discusses the identification and distribution of enkephalins and endorphins. The two main methods of detecting and quantitating enkephalins and endorphins used so far are radioimmunoassay and bioassay. In addition, opioid receptor binding assays were originally utilized to detect general opioid activity.
Richard J. Miller, Pedro Cuatrecasas
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The assay of Met-enkephalin aminopeptidase with [125I]Met-enkephalin
Journal of Biochemical and Biophysical Methods, 1982Presented here are procedural modifications which permit the utilization of 125I-labeled Met-enkephalin as substrate in the assay of rat brain enkephalin aminopeptidase. Th hydrolysis of enkephalin is monitored by the release of [125I]tyrosine separated on Porapak Q.
James L. Caffrey, Donald H. Hodges
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Enkephalin-containing polypeptides are potent inhibitors of enkephalin degradation
Peptides, 1983Enkephalin-containing polypeptides derived from pro-enkephalin A, pro-enkephalin B, or pro-opiomelanocortin were inhibitors of enkephalin degradation by aminoenkephalinases purified from cytosol or membranes. Of the peptides, Argo-Met-enkephalin was the most potent inhibitor for the aminoenkephalinases, with an IC50 of about 0.6 microM, it was more ...
Nicholas Ling +5 more
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Enkephalin Release and Enkephalin-Precursors in Chicken Retina [PDF]
, 1989 The demonstration of enkephalin-like immunoreactive neurons (Brecha, et al., 1979), opiate receptors (Osborne and Hertz, 1981; Slaughter, et al., 1985) and opiate-affected ganglion cell responses (Djamgoz, et al., 1981; Dick and Miller, 1981) favour the acceptance of an opiate-transmitter system in vertebrate retina.
Mark Dowton +2 more
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Enkephalins and nigrostriatal function
Neurology, 1978Unilateral lesions of the substantia nigra were made with 6-hydroxydopamine in rats. In this model, drugs such as naloxone, which block endogenous enkephalin receptors, potentiated agents with postsynaptic dopaminergic actions, while antagonizing agents with presynaptic dopaminergic actions.
Richard L. Borison, Bruce I. Diamond
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Spontaneous inactivation of enkephalin
Biochemical and Biophysical Research Communications, 1978Summary Dilute solutions of enkephalin are not stable upon prolonged storage. A new peak of UV absorption (at 325 nm) gradually appears. This change in spectral properties is accompanied by an alteration in the chromatographic pattern as well as the spontaneous modification of the tyrosyl residue of the enkephalin molecule.
Talia Miron +3 more
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