Results 261 to 270 of about 17,087 (287)
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International Journal of Peptide and Protein Research, 1983
Two kinds of dehydropeptide analogs of enkephalin containing a ΔTyr unit at the N‐terminus have been synthesized by coupling Boc‐ΔTyr‐(Cl2Bzl)‐OH with amino acid amides and tetrapeptide esters using the water soluble carbodiimide‐HOBt method. Pentapeptides consisting of ΔTyr1, and ΔPhe4 or ΔLeu5 were also prepared.
Aldean J. Kolar +3 more
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Two kinds of dehydropeptide analogs of enkephalin containing a ΔTyr unit at the N‐terminus have been synthesized by coupling Boc‐ΔTyr‐(Cl2Bzl)‐OH with amino acid amides and tetrapeptide esters using the water soluble carbodiimide‐HOBt method. Pentapeptides consisting of ΔTyr1, and ΔPhe4 or ΔLeu5 were also prepared.
Aldean J. Kolar +3 more
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European Journal of Pharmacology, 1980
Morphine is known to produce mydriasis in mice. We have found that enkephalins caused a similar effect. Morphine was twice as active as D-Ala-D-Leu-enkephalin (BW-180C), 5 times as active as Met-enkephalin and 7 times as active as Leu-enkephalin. The time course of the effect was shortest for the enkephalins ( t 1/2 = 8-12 min), intermediate for BW ...
Yechiel Eshel +2 more
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Morphine is known to produce mydriasis in mice. We have found that enkephalins caused a similar effect. Morphine was twice as active as D-Ala-D-Leu-enkephalin (BW-180C), 5 times as active as Met-enkephalin and 7 times as active as Leu-enkephalin. The time course of the effect was shortest for the enkephalins ( t 1/2 = 8-12 min), intermediate for BW ...
Yechiel Eshel +2 more
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International Journal of Peptide and Protein Research, 1982
The Gly3residue in Gly2‐ and D‐Ala2‐enkephalins has been replaced by ΔAla3and Ser3in order to examine the effect on binding to the Δ and μ opiate receptors. [D‐Ala2, ΔAla3, Leu5]‐enkephalin maintains most of its receptor binding affinities for both sites.
Yasuyuki Shimohigashi +1 more
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The Gly3residue in Gly2‐ and D‐Ala2‐enkephalins has been replaced by ΔAla3and Ser3in order to examine the effect on binding to the Δ and μ opiate receptors. [D‐Ala2, ΔAla3, Leu5]‐enkephalin maintains most of its receptor binding affinities for both sites.
Yasuyuki Shimohigashi +1 more
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Enkephalin in the goldfish retina [PDF]
Cellular and Molecular Neurobiology, 1986 Enkephalin-like immunoreactive amacrine cells were visualized using the highly sensitive avidin-biotin method. The somas of these cells were situated in the inner nuclear and ganglion cell layers. Enkephalin-stained processes were observed in layers 1, 3, and 5 of the inner plexiform layer.
C.B. Watt +3 more
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On the Origin of Leu-Enkephalin and Met-Enkephalin in the Rat Neurohypophysis
Endocrinology, 1985The posterior lobe of the pituitary contains large amounts of Leu- and Met-enkephalin (LE and ME, respectively). A marked depletion of ME (81.9%) and LE (94.5%) in the posterior pituitary occurred after transection of the pituitary stalk. This indicates that most, if not all, of the enkephalins are in processes of central neurons. In the present study,
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1990
Morphine, an opium alkaloid derived from the poppy, Papaver somniferum, has been one of the most commonly used analgesics in both clinical and experimental fields despite its addictive properties. In 1975, after a specific opiate receptor had been demonstrated, two endogenous opioid peptides, methionine enkephalin (Met-enk) and leucine enkephalin (Leu ...
Teruo Kudo, Reizo Inoki
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Morphine, an opium alkaloid derived from the poppy, Papaver somniferum, has been one of the most commonly used analgesics in both clinical and experimental fields despite its addictive properties. In 1975, after a specific opiate receptor had been demonstrated, two endogenous opioid peptides, methionine enkephalin (Met-enk) and leucine enkephalin (Leu ...
Teruo Kudo, Reizo Inoki
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Potent tetrapeptide enkephalins
Life Sciences, 1981Abstract Small peptides with opiate-like activity have generally had structures closely resembling that of the opioid pentapeptide enkephalin: Tyr-Gly-Gly-Phe-Met-COOH. Single deletions of any one of the amino acids has been demonstrated to reduce opiate activity drastically.
Richard E. Chipkin +6 more
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2016
Enkephalins are endogenous opioid pentapeptides that are produced mainly in the central nervous system, adrenal medulla, and other peripheral tissues. There are two structurally different enkephalin peptides: Met-enkephalin (YGGFM), and Leu-enkephalin (YGGFL).
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Enkephalins are endogenous opioid pentapeptides that are produced mainly in the central nervous system, adrenal medulla, and other peripheral tissues. There are two structurally different enkephalin peptides: Met-enkephalin (YGGFM), and Leu-enkephalin (YGGFL).
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Clinical and Experimental Pharmacology and Physiology, 1989
SUMMARY1. A radio‐immunoassay (RIA) for methionine‐enkephalin sulfoxide was developed and was used to measure methionine‐enkephalin, after oxidation, in the rat brain.2. The RIA was performed together with assays that use commercially available met‐and leu‐enkephalin antisera.3.
George K. L. Tiong, Jean E. Olley
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SUMMARY1. A radio‐immunoassay (RIA) for methionine‐enkephalin sulfoxide was developed and was used to measure methionine‐enkephalin, after oxidation, in the rat brain.2. The RIA was performed together with assays that use commercially available met‐and leu‐enkephalin antisera.3.
George K. L. Tiong, Jean E. Olley
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The metabolic stability of the enkephalins
Biochemical and Biophysical Research Communications, 1977Abstract [Met 5 ] and [Leu 5 ]-enkephalins inhibit 3 H-naloxone binding to brain opiate receptors much more effectively at 4°C than at 25°C. At 25°C several protease inhibitors potentiate the action of the enkephalins. Bacitracin is the most effective of these.
Kwen-Jen Chang +3 more
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