Results 111 to 120 of about 744,448 (280)

The Impact of EU Enlargement on European Border Regions [PDF]

open access: yes
EU enlargement is supposed to entail profound impact on the location of economic activities in Europe. Although there is concern about the implications of enlargement for regional disparities in the EU, corresponding empirical results are still rare. The
Annekatrin Niebuhr
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

The Impact of The European Enlargement and CAP Reforms on Agricultural Markets. Much Ado about Nothing? [PDF]

open access: yes
We analyze the effects of the 2004 CAP reform and EU enlargement on European and world agricultural markets. We compare the results from a CAP reform only and a CAP reform plus enlargement scenarios to a no-enlargement baseline implementing Agenda 2000 ...
Beghin, John C.   +7 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Has EU Enlargement Been, and Will It Continue to Be, a Success? An Evaluation of EU Enlargement's Effects on Policies Pursued by Candidate Countries [PDF]

open access: yes
In this paper, I discuss whether enlargement has been a successful external policy of the European Union (EU). In particular, I evaluate the policy’s success based on its effects on the policies candidate countries have pursued. I argue that the prospect
Hlavac, Marek
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Sizing It Up: Labor Migration Lessons of the EU Enlargement to 27 [PDF]

open access: yes
While economists were pointing out the advantages of the EU enlargement, politicians and policymakers were raising grave concerns about the significant political and economic differences between the newcomer states (EU12) and the "old Europe" of EU15 ...
Constant, Amelie F.
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

The Social Aspects of Enlargement

open access: yesEuropean Journal of Spatial Development, 2004
The report is likely to have a central role in shaping policy discussions on cohesion and regional development related issues for the foreseeable future, not least because it provides a blueprint for European cohesion policy after EU-enlargement in May ...
Ilari Karppi
doaj  

The macroeconomic consequences of migration diversion: evidence for Germany and the UK [PDF]

open access: yes
This paper examines the macroeconomic consequences of the diversion of migration flows away from Germany towards the UK in the course of the EUâs Eastern Enlargement.
Herbert Brücker, Timo Baas
core  

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