Results 101 to 110 of about 100,569 (330)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Association of VNTR 27-bp polymorphism in intron 4 of the eNOS3 gene and predisposition to Ischemic Heart Disease among Taif population in Saudi Arabia [PDF]

Network Biology, 2020
Genetic variation and polymorphism became a hot spot for researches to study the link between societies and certain endemic diseases. This study is an attempt to examine the possible association of the incidence of ischemic heart disease with the genetic
Adel Qlayel Alkhedaide, Adil Mergani, Mohamed Mohamed Soliman, et al.   +2 more
doaj  

Linear Discontinuity Sharpening for Highly Resolved and Robust Magnetohydrodynamics Simulations

International Journal for Numerical Methods in Fluids, EarlyView.
This study applies a reconstruction scheme, “hybrid MUSCL–THINC” for finite volume methods developed by Chiu et al., to magnetohydrodynamics (MHD) simulations. Furthermore, the robustness is improved by a modification that deactivates an artificial compression by THINC depending on the non‐linearity of MHD discontinuities.
Tomohiro Mamashita, Gaku Fukushima, Keiichi Kitamura   +2 more
wiley   +1 more source

Insights into the arginine paradox: evidence against the importance of subcellular location of arginase and eNOS.

American Journal of Physiology. Heart and Circulatory Physiology, 2013
Reduced production of nitric oxide (NO) is one of the first indications of endothelial dysfunction and precedes overt cardiovascular disease. Increased expression of Arginase has been proposed as a mechanism to account for diminished NO production ...
S. Elms, Feng Chen, Yusi Wang, Jin Qian, B. Askari, Yanfang Yu, D. Pandey, J. Iddings, R. Caldwell, D. Fulton   +9 more
semanticscholar   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, EarlyView.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source

Possível Influência do Fenômeno Climático Oceânico-Atmosférico El Niño Oscilação Sul (ENOS) sobre a Precipitação Acumulada Mensal em Campos dos Goytacazes, RJ, Brasil

Boletim do Observatório Ambiental Alberto Ribeiro Lamego, 2019
Este estudo se baseia na hipótese de existir alguma relação entre o fenômeno climático oceânico-atmosférico El Niño Oscilação Sul (ENOS) e o comportamento do clima no município de Campos dos Goytacazes, situado ao norte do estado do Rio de Janeiro, na ...
Antonio Ivo Gomes Barbosa, Gustavo Henrique Naves Givisiez, Eduardo Manuel Rosa Bulhoes   +2 more
doaj   +1 more source

Endothelial dysfunction in children with obstructive sleep apnea is associated with epigenetic changes in the eNOS gene.

Chest, 2013
BACKGROUND Obstructive sleep apnea (OSA) is a highly prevalent disorder that has been associated with an increased risk for cardiovascular morbidity, even in children.
L. Kheirandish-Gozal, A. Khalyfa, D. Gozal, R. Bhattacharjee, Yang Wang   +4 more
semanticscholar   +1 more source

Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular‐Related Complications

Molecular Nutrition &Food Research, EarlyView.
(Poly)phenols constitute a source of natural therapeutic molecules capable of targeting angiogenesis in different scenarios. This review summarizes the current evidence of the role of (poly)phenols in modulating angiogenesis. The reader can find a compilation of preclinical and human investigations describing pro‐ and anti‐angiogenic effects of these ...
María Ángeles Ávila‐Gálvez, Antonio Vico‐Padilla, Claus Schneider, Juan Carlos Espín, Antonio González‐Sarrías, Juan Antonio Giménez‐Bastida   +5 more
wiley   +1 more source

Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice.

American Journal of Physiology. Heart and Circulatory Physiology, 2013
Nitric oxide (NO) can modulate arterial stiffness by regulating both functional and structural changes in the arterial wall. Tissue transglutaminase (TG2) has been shown to contribute to increased central aortic stiffness by catalyzing the cross-linking ...
S. Jung, Simran Jandu, J. Steppan, A. Belkin, S. An, Alina Pak, E. Y. Choi, D. Nyhan, M. Butlin, Kayla D Viegas, A. Avolio, D. Berkowitz, L. Santhanam   +12 more
semanticscholar   +1 more source

Thiostrepton Suppresses the Progression of Rhabdomyosarcoma by Inhibiting the PI3K‐AKT Signaling Pathway

Pediatric Discovery, EarlyView.
The study establish TST as a multi‐mechanism PI3K‐AKT inhibitor for refractory RMS while validating Cmap‐driven drug repurposing for pediatric oncology. ABSTRACT Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma with 5‐year survival below 30% in high‐risk/metastatic cases, was investigated through integrated bioinformatics analysis (
Yu Wang, Peng Hong, Zhiqiang Gao, Wei Ma, Zaihong Hu, Jie Lin, Kongkong Cui, Qinlin Shi, Xiao‐Mao Tian, Guanghui Wei   +9 more
wiley   +1 more source