Results 121 to 130 of about 92,487 (246)
Паёми СиноObjective: o study genetic associations of age-related macular degeneration (AMD) with polymorphisms of the MMP9, CYP, and eNOS genes using modern molecular genetic methods, in order to assess their contribution to disease development and identify ...
Plotnikov Denis Yurievich +1 more
doaj +1 more source
Regulation of endothelial nitric oxide synthase by phosphorylation [PDF]
, 2007 Since its recognition as an endothelium-derived relaxing factor, the control and consequences of nitric oxide (NO) production have been investigated intensely.
Mohamed, Annisuddin
core
Dietary melatonin and its benefits on cardiovascular disease
British Journal of Pharmacology, EarlyView.Cardiovascular disease remains the leading cause of mortality globally, with a disproportionate burden in low‐ and middle‐income countries. Melatonin, a hormone primarily produced by the pineal gland, exhibits notable antioxidant, anti‐inflammatory and immunomodulatory properties that may confer cardiovascular benefits.
Karabo Tisane +2 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Atherosclerosis, a chronic inflammatory disease characterised by lipid accumulation and endothelial dysfunction, remains a leading cause of cardiovascular morbidity and mortality. While cannabinoid 2 (CB2) receptor agonists show therapeutic promise in preclinical studies, their systemic application is hindered by poor ...
Lucía Martín‐Navarro +3 more
wiley +1 more source
International Journal of NanomedicineLingzhi Lai,1 Hao Wu,1 Liang Peng,2 Zhen Zhang,3 Xinfan Wu,1 Shuo Zheng,3 Zekang Su,3 Hongxing Chu3 1Maoming People’s Hospital, Maoming, Guangdong, People’s Republic of China; 2The First People’s Hospital of Guiyang, Guiyang, Guizhou, People’s Republic ...
Lai L +7 more
doaj
Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou +5 more
wiley +1 more source
Common pathways and outliers in glucose catabolism across Trypanosomatidae
The FEBS Journal, EarlyView.Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes +5 more
wiley +1 more source
Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance
The FEBS Journal, EarlyView.Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley +1 more source
Fisheries Management and Ecology, EarlyView.ABSTRACT Hydroelectric dams are common in Amazonian tributaries under federal environmental licensing that requires long‐term fisheries monitoring. This study evaluated three fishing systems targeting “pacu” species (Serrasalmidae) in the Xingu River before, during, and after construction of the Belo Monte dam (2012–2023) across four river sectors ...
João Paulo Moura de Queiroz +5 more
wiley +1 more source
FTO/m6A Regulate Prenatal Nicotine-Induced eNOS Uncoupling and BP Susceptibility. [PDF]
HypertensionLiu B +11 more
europepmc +1 more source