Results 31 to 40 of about 214,822 (255)
Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells
Molecular Biology of the Cell, 2018 We hypothesized that the maintenance of vascular homeostasis is critically dependent on the expression and reciprocal regulation of caveolin-1 (Cav-1) and endothelial nitric oxide synthase (eNOS) in endothelial cells (ECs).
Zhenlong Chen +9 more
semanticscholar +1 more source
eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally [PDF]
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2006 At birth, the transition to gas breathing requires the function of endothelial vasoactive agents. We investigated the function of endothelial nitric oxide synthase (eNOS) in pulmonary artery (PA) vessels and endothelial cells isolated from fetal and young (4-wk) sheep. We found greater relaxations to the NOS activator A-23187 in 4-wk-old compared with
Eugenia, Mata-Greenwood +7 more
openaire +2 more sources
“Non alcoholic fatty liver disease and eNOS dysfunction in humans”
BMC Gastroenterology, 2017 BackgroundNAFLD is associated to Insulin Resistance (IR). IR is responsible for Endothelial Dysfunction (ED) through the impairment of eNOS function. Although eNOS derangement has been demonstrated in experimental models, no studies have directly shown ...
M. Persico +8 more
semanticscholar +1 more source
Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties [PDF]
, 2011 Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to ...
Gibson, Colin +4 more
core +1 more source
Архивъ внутренней медицины, 2016 Coronary heart disease (CHD) is a major cause of mortality. Morphological substrate of CHD in most cases is atherosclerosis, which is based on structural genes polymorphism eNOS and AGTR2.
A. L. Khokhlov +4 more
doaj +1 more source
Sex-specific eNOS activity and function in human endothelial cells
Scientific Reports, 2017 Clinical and epidemiological data show that biological sex is one of the major determinants for the development and progression of cardiovascular disease (CVD).
M. Cattaneo +7 more
semanticscholar +1 more source
Increased eNO and pulmonary iNOS expression in eNOS null mice [PDF]
European Respiratory Journal, 2003 Nitric oxide (NO) is a major regulatory molecule of the cardiovascular system; however, measurement of vascular NO synthesisin vivorepresents a major challenge. NO stemming from the lower respiratory tract has been used as a marker of vascular endothelial function. Experimental evidence for this concept is lacking.
S, Cook +5 more
openaire +2 more sources
PHARMACOGENETIC FEATURES OF THERAPY OF PATIENTS WITH ATHEROSCLEROSIS
Архивъ внутренней медицины, 2018 The complexity of therapy of lipid metabolism disorders is not only in comorbidity and polypragmasia, but also in predicting a genetically determined response to the treatment.
A. L. Khokhlov +7 more
doaj +1 more source
The efficacy of nitric oxide in stroke (ENOS) trial – where do we stand in Romania? [PDF]
Romanian Journal of Neurology, 2012 Introduction. Romania ranks third worldwide for stroke mortality. Although high blood pressure (BP) is a major risk factor for stroke incidence and determinant of outcome, the management of BP in acute stroke remains undefined. The present study assesses
Szocs Ildiko +7 more
doaj +1 more source
Cardiovascular Diabetology, 2016 BackgroundEndothelial dysfunction has been suggested as a possible causal link between hyperglycemia and microvascular complications in diabetes mellitus. The effect of metformin on endothelial progenitor cells (EPCs) is still unclear.
Jiawen Yu +5 more
semanticscholar +1 more source