Results 31 to 40 of about 177,036 (313)

Should the non‐canonical pathway of nitric oxide generation be targeted in hypertensive pregnancies?

British Journal of Pharmacology, EarlyView., 2023
Abstract Hypertension in pregnancy is prevalent, affecting around 10% of pregnancies worldwide, and significantly increases the risk of adverse outcomes for both mothers and their babies. Current treatment strategies for pregnant women with hypertension are limited, and new approaches for the management of hypertension in pregnancy are urgently needed.
Elizabeth C. Cottrell
wiley   +1 more source

T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity. [PDF]

, 2017
BACKGROUND: Endothelial dysfunction plays a critical role in the development of type 2 diabetes (T2DM). T-cadherin (T-cad) has gained recognition as a regulator of endothelial cell (EC) function.
Ambrosio, Anastasia, Lau, Wayne Bond, Ma, Xin-Liang, Summer, Ross, Tao, Ling, Wang, Han, Wang, Yajing, Yan, Wenjun   +7 more
core   +2 more sources

Hydrogen Sulfide Donor GYY4137 Acts Through Endothelial Nitric Oxide to Protect Intestine in Murine Models of Necrotizing Enterocolitis and Intestinal Ischemia [PDF]

, 2019
BACKGROUND: Necrotizing enterocolitis (NEC) in premature infants is often a devastating surgical condition with poor outcomes. GYY4137 is a long-acting donor of hydrogen sulfide, a gasotransmitter that is protective against intestinal injury in ...
Drucker, Natalie A., Jensen, Amanda R., Markel, Troy A., Te Winkel, Pieter Jan   +3 more
core   +1 more source

Vascular remodeling of the mouse yolk sac requires hemodynamic force [PDF]

, 2007
The embryonic heart and vessels are dynamic and form and remodel while functional. Much has been learned about the genetic mechanisms underlying the development of the cardiovascular system, but we are just beginning to understand how changes in heart ...
Chen, Ju, Dickinson, Mary E., Fraser, Scott E., Huang, Chengqun, Jones, Elizabeth A. V., Lucitti, Jennifer L.   +5 more
core   +1 more source

Análisis del impacto del fenómeno del Monzón en la producción agrícola de la India

Journal de Ciencias Sociales, 2016
La producción agrícola de la India se ve afectada por el fenómeno del Monzón, que significa estación, lo cual explica su aplicación a los cambios estacionales a gran escala del régimen de los vientos y la alternancia de un período seco y otro húmedo. El
María Guillermina Diaz
doaj   +1 more source

The effects of severe hypoxia on nitric oxide parameters in hypoxia-tolerant rodent: nannospalax nehringi [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018
Blind mole rats (BMRs) are solitary rodents which are tolerant to severe hypoxia. The aim of this study is to reveal the changes in nitric oxide (NO) and nitric oxide enzymes (NOS), which are involved in many physiological and pathological processes ...
Barış YILDIZ, Nadide Nabil KAMİLOĞLU, Metin ÖĞÜN, Cem ÖZİÇ, Oğuz MERHAN, Tarık MECİT, Yüksel COŞKUN   +6 more
doaj   +1 more source

Placental protein 13 (PP13)-induced vasodilation of resistance arteries from pregnant and nonpregnant rats occurs via endothelial-signaling pathways

Hypertension in Pregnancy, 2017
Placental protein 13 (PP13) induces hypotension in rats. This study aims to evaluate PP13 effects on isolated uterine arteries from nonpregnant and mid-pregnant rats.
Tijana Drobnjak, Sveinbjörn Gizurarson, Natalia I. Gokina, Hamutal Meiri, Maurizio Mandalá, Berthold Huppertz, George Osol   +6 more
doaj   +1 more source

REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA

Рациональная фармакотерапия в кардиологии, 2016
Methylated analogs of L-arginine - asymmetric dimetilarginin (ADMA) and monometilarginin (L-NMMA) - are endogenous inhibitors of endothelial NO-synthase (eNOS). ADMA level in maternal plasma is increased in women with preeclampsia. The high level of ADMA
M. V. Pokrovsky, N. G. Filipenko, M. V. Korokin, V. V. Gureyev, T. G. Pokrovsky, A. A. Barsuk, L. V. Korokina, E. V. Proskuryakova, N. V. Maltseva, O. V. Levashova, O. S. Gudyrev, A. S. Belous, O. S. Polyanskaya   +12 more
doaj   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Stranded Marine Mammals on the South-Central Coast of Peru during El Niño 1997-98

Revista Peruana de Biología
During the 1997-98 El Niño event, an assessment of marine mammal strandings was conducted from August 1997 to April 1998 between 15°22' and 15°27' S. This assessment encompassed 30.4 km of coastline, distributed in seven sectors located along the borders
Manuel Apaza
doaj   +1 more source