Results 31 to 40 of about 100,569 (330)
Alʹmanah Kliničeskoj Mediciny, 2023 Background: Patients with treatment-resistant hypertension have a worse cardiovascular prognosis compared to those who achieve their target levels of blood pressure (BP). One of biochemical and clinical markers of a decreased response to antihypertensive
Aleksandr N. Stafeev +2 more
doaj +1 more source
International Journal of Molecular Medicine, 2016 The mechanism by which hyperuricemia induced-endothelial dysfunction contributes to cardiovascular diseases (CVDs) is not yet fully understood. In the present study, we used uric acid (UA) to trigger endothelial dysfunction in cultured endothelial cells,
Peng Li +4 more
semanticscholar +1 more source
Catechins inhibit atherosclerosis in male rats on a high fat diet
Universa Medicina, 2015 Background A catechin isolate from the green tea clone GMB 4, which shows antioxidant activity, may be a candidate drug for prevention of atherosclerosis.
Erna Susanti +2 more
doaj +1 more source
Molecular mechanisms underlying pharmacological stimulation of eNOS expression and eNOS activity
BMC Pharmacology, 2009 Endothelium-derived nitric oxide (NO) generated by endothelial NO synthase (eNOS) is a key regulator of endothelial function. Vascular NO induces vasodilation, inhibits platelet aggregation and adhesion, prevents oxidative modification of LDL cholesterol, limits vascular smooth-muscle-cell proliferation, and decreases the expression of proinflammatory ...
Alice Habermeier +8 more
openaire +2 more sources
Signal transduction of eNOS activation [PDF]
Cardiovascular Research, 1999 Consistent with its classification as a Ca2+/calmodulin-dependent enzyme the constitutive endothelial nitric oxide (NO) synthase (eNOS) can be activated by receptor-dependent and -independent agonists as a consequence of an increase in the intracellular concentration of free Ca2+ ([Ca2+]i) and the association of the Ca2+/calmodulin complex with eNOS ...
Ingrid Fleming, Rudi Busse
openaire +3 more sources
Sex-specific eNOS activity and function in human endothelial cells
Scientific Reports, 2017 Clinical and epidemiological data show that biological sex is one of the major determinants for the development and progression of cardiovascular disease (CVD).
M. Cattaneo +7 more
semanticscholar +1 more source
Journal of Human Hypertension, 2016 Disruption of nitric oxide pathway and endoplasmic reticulum (ER) stress had been observed in preeclampsia (PE). However, the correlation and overall detailed expression profiles of ER stress-related markers and endothelial nitric oxide synthase ...
L. Du +5 more
semanticscholar +1 more source
Upregulation and Activation of eNOS by Resveratrol [PDF]
Circulation, 2003 To the Editor: Wallerath et al1 reported that the stilbene derivative trans-resveratrol, an ingredient of red wine, stimulates acute nitric oxide (NO) release from vascular endothelial cells and induces upregulation of endothelial nitric oxide synthase (eNOS) gene expression after 24 to 72 hours incubation.
Dirk Taubert, Reinhard Berkels
openalex +3 more sources
“Non alcoholic fatty liver disease and eNOS dysfunction in humans”
BMC Gastroenterology, 2017 BackgroundNAFLD is associated to Insulin Resistance (IR). IR is responsible for Endothelial Dysfunction (ED) through the impairment of eNOS function. Although eNOS derangement has been demonstrated in experimental models, no studies have directly shown ...
M. Persico +8 more
semanticscholar +1 more source
Effects of resveratrol on eNOS in the endothelium and the perivascular adipose tissue
Annals of the New York Academy of Sciences, 2017 Under physiological conditions, nitric oxide (NO) is produced in the vasculature mainly by the endothelial NO synthase (eNOS). Experiments using gene‐disrupted mice have demonstrated that eNOS has antihypertensive, antithrombotic, and antiatherosclerotic
N. Xia, U. Förstermann, Huige Li
semanticscholar +1 more source