Genetic Susceptibility to Retinopathy of Prematurity: A Paradigm for Preterm Disease Traits
Delhi Journal of Ophthalmology, 2014 Retinopathy of prematurity (ROP) is a vasoproliferative retinal disorder in premature infants that can lead to blindness and the incidence is increasing with increased survival of infants born at very early gestational age and low birth weight.
Manzoor Ahmad Malik +3 more
doaj +1 more source
Differential effects of heat shock protein 90 and serine 1179 phosphorylation on endothelial nitric oxide synthase activity and on its cofactors. [PDF]
PLoS ONE, 2017 Endothelial nitric oxide synthase (eNOS) is responsible for maintaining systemic blood pressure, vascular remodeling and angiogenesis. Previous studies showed that bovine eNOS serine 1179 (Serine 1177 for human eNOS) phosphorylation enhanced NO synthesis.
Yuanzhuo Chen +4 more
doaj +1 more source
PLoS ONE, 2014 Gram positive (G+) infections make up ∼50% of all acute lung injury cases which are characterized by extensive permeability edema secondary to disruption of endothelial cell (EC) barrier integrity.
Feng Chen +11 more
semanticscholar +1 more source
The Characteristics and Regulatory Mechanisms of Superoxide Generation from eNOS Reductase Domain. [PDF]
PLoS ONE, 2015 In addition to superoxide (O2.-) generation from nitric oxide synthase (NOS) oxygenase domain, a new O2.- generation site has been identified in the reductase domain of inducible NOS (iNOS) and neuronal NOS (nNOS).
Hu Peng +4 more
doaj +1 more source
Deciphering the Binding of Caveolin-1 to Client Protein Endothelial Nitric-oxide Synthase (eNOS)
Journal of Biological Chemistry, 2014 Background: One of the most significant client proteins of Cav-1 is the endothelial nitric-oxide synthase (eNOS), but their specific binding site is unknown.
Andy E. Trane +8 more
semanticscholar +1 more source
, 2003 Myocardial constitutive No production depends on the activity of both endothelial and neuronal NOS (eNOS and nNOS, respectively). Stimulation of myocardial β(3)-adrenergic receptor (β(3)-AR) produces a negative inotropic effect that is dependent on eNOS.
Balligand, Jean-Luc +8 more
core +1 more source
Antioxidants, 2019 Congenital heart defects (CHDs) are the most prevalent and serious birth defect, occurring in 1% of all live births. Pregestational maternal diabetes is a known risk factor for the development of CHDs, elevating the risk in the child by more than four ...
Anish Engineer +3 more
doaj +1 more source
Serine 1179 Phosphorylation of Endothelial Nitric Oxide Synthase Increases Superoxide Generation and Alters Cofactor Regulation. [PDF]
PLoS ONE, 2015 Endothelial nitric oxide synthase (eNOS) is responsible for maintaining systemic blood pressure, vascular remodeling and angiogenesis. In addition to producing NO, eNOS can also generate superoxide (O2-.) in the absence of the cofactor ...
Hu Peng +5 more
doaj +1 more source
Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities [PDF]
, 2003 Antioxidant vitamins C and E have protective properties in genetic hypertension associated with enhanced oxidative stress. This study investigated whether vitamins C and/or E modulate vascular function by regulating enzymatic activities of endothelial ...
Bayraktutan, Ulvi +2 more
core +2 more sources
Effects of Nitric Oxide Synthase Isoforms During Experimental Tooth Movement
Turkish Journal of Orthodontics, 2012 Aim:Many systemic/local factors take part in the process of bone-remodeling. Nitric oxide (NO), an important intercellular signal modulator produced by osteoblasts, is a potent regulator of bone-remodeling.
Hasan Bülbül +5 more
doaj +1 more source