Results 61 to 70 of about 173,115 (211)

REALITIES AND PROSPECTS FOR PHARMACOLOGICAL CORRECTION OF «ADMA-ENOS"-ASSOCIATED WAYS IN PREECLAMPSIA

Рациональная фармакотерапия в кардиологии, 2016
Methylated analogs of L-arginine - asymmetric dimetilarginin (ADMA) and monometilarginin (L-NMMA) - are endogenous inhibitors of endothelial NO-synthase (eNOS). ADMA level in maternal plasma is increased in women with preeclampsia. The high level of ADMA
M. V. Pokrovsky, N. G. Filipenko, M. V. Korokin, V. V. Gureyev, T. G. Pokrovsky, A. A. Barsuk, L. V. Korokina, E. V. Proskuryakova, N. V. Maltseva, O. V. Levashova, O. S. Gudyrev, A. S. Belous, O. S. Polyanskaya   +12 more
doaj   +1 more source

The Characteristics and Regulatory Mechanisms of Superoxide Generation from eNOS Reductase Domain. [PDF]

PLoS ONE, 2015
In addition to superoxide (O2.-) generation from nitric oxide synthase (NOS) oxygenase domain, a new O2.- generation site has been identified in the reductase domain of inducible NOS (iNOS) and neuronal NOS (nNOS).
Hu Peng, Yugang Zhuang, Yuanzhuo Chen, Alicia N Rizzo, Weiguo Chen   +4 more
doaj   +1 more source

Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents? [PDF]

, 2006
It has been postulated that endothelial cell injury is the initiating event in the pathogenesis of systemic sclerosis, causing attraction, attachment, migration and infiltration of activated T-cells and subsequent production of cytokines and growth ...
Derk, Chris T., Jimenez, Sergio A.
core   +2 more sources

Association between Genetic Variants of Nitric Oxide/cGMP Pathway and Susceptibility to Hypertension in Kermanshah Province

Journal of Mazandaran University of Medical Sciences, 2023
Background and purpose: Hypertension is a global health challenge due to its high prevalence and increased risk of cardiovascular disease. It is a multifactorial disease in which both genetic and environmental factors are involved.
Parham Nejati, Saba Naseri, Maryam Eini, Reza Alibakhshi, Sousan Mahmoudi, Lida Haghnazari, Nazanin Jalilian   +6 more
doaj  

Serine 1179 Phosphorylation of Endothelial Nitric Oxide Synthase Increases Superoxide Generation and Alters Cofactor Regulation. [PDF]

PLoS ONE, 2015
Endothelial nitric oxide synthase (eNOS) is responsible for maintaining systemic blood pressure, vascular remodeling and angiogenesis. In addition to producing NO, eNOS can also generate superoxide (O2-.) in the absence of the cofactor ...
Hu Peng, Yugang Zhuang, Mark C Harbeck, Donghong He, Lishi Xie, Weiguo Chen   +5 more
doaj   +1 more source

Reduction of blood pressure, plasma cholesterol, and atherosclerosis by elevated endothelial nitric oxide. [PDF]

, 2002
In the vascular system, nitric oxide is generated by endothelial NO synthase (eNOS). NO has pleiotropic effects, most of which are believed to be atheroprotective.
Bakker, Barend Mees, Barton, Breslow, Brown, d'Uscio, Daugherty, de Crom, Dirk J. Duncker, Drummond, Elza van Deel, Everson, Feron, Feron, Forstermann, Frank Grosveld, Fulton, Garcia-Cardena, Gordon, Govers, Harrison, Hoit, Huang, Jaap Hamming, Janssens, Kamphoven, Kano, Kincer, Knowles, Kuhlencordt, Laumonnier, Lefer, Li, Libby, Loscalzo, Marletta, Michael Kutryk, Monique de Waard, Murayama, Nakashima, Niebauer, O'Donnell, Ohashi, Ozaki, Paigen, Qian, Riddell, Rien van Haperen, Rini de Crom, Sessa, Sjoland, Thijs van Aken, van Haperen, Wever, Xia   +54 more
core   +1 more source

Nitric oxide synthase inhibition attenuates cardiac response to hemodilution with viscogenic plasma expander. [PDF]

, 2014
Background and objectivesIncreased vascular wall shear stress by elevated plasma viscosity significantly enhances the endothelial nitric oxide synthase (eNOS) activity during an acute isovolemic hemodilution.
Cabrales, Pedro, Chatpun, Surapong
core   +2 more sources

Predictive analysis and prediction of the main molecular targets for the N-acetyl-6-aminohexanoate derivative

Research Results in Pharmacology
Introduction: N-acetyl-6-aminohexanoate (acexamic acid) and its derivatives are actively studied as promising compounds for the creation of new drugs, but their pharmacokinetic parameters and detailed mechanisms underlying a wide range of biochemical ...
Anton P. Danilenko, Alexey A. Khentov, Alexey V. Kuznetsov, Veronika S. Shmigerova, Yulia V. Stepenko, Alla P. Tarasova, Vladimir I. Yakushev, Elizaveta V. Boeva, Albina V. Miller, Irina A. Tatarenkova, Tatiana V. Puzanova, Yana V. Loboda, Andrei P. Trashchenko, Oleg S. Gudyrev, Anna L. Motailo, Vladimir N. Kuzichkin, Valentina N. Milashechko, Lyudmila M. Danilenko   +17 more
doaj   +1 more source

Effects of El Niño on the dynamics of Lake Alchichica, central Mexico

Geofísica Internacional, 2003
Se presenta evidencia empírica que muestra los efectos contemporáneos del fenómeno El Niño Oscilación del Sur sobre Alchichica, un lago profundo, monomíctico cálido.
Javier Alcocer, Alfonso Lugo
doaj   +1 more source

c-Src inhibition improves cardiovascular function but not remodeling or fibrosis in Ang II-induced hypertension [PDF]

, 2016
c-Src plays an important role in angiotensin II (Ang II) signaling. Whether this member of the Src family kinases is involved in the development of Ang II–induced hypertension and associated cardiovascular damage in vivo remains unknown. Here, we studied
Antunes, Tayze T., Callera, Glaucia E., He, Ying, Montezano, Augusto C., Savoia, Carmine, Touyz, Rhian M., Yogi, Alvaro   +6 more
core   +1 more source