Results 1 to 10 of about 24,106 (152)

Development of Lipid–Polymer Hybrid Nanoparticles for Improving Oral Absorption of Enoxaparin

Pharmaceutics, 2020
Enoxaparin, an anticoagulant that helps prevent the formation of blood clots, is administered parenterally. Here, we report the development and evaluation of lipid–polymer hybrid nanoparticles (LPHNs) for the oral delivery of enoxaparin.
Bo Tang, Guihua Fang
exaly   +3 more sources

Biosimilar versus branded enoxaparin to prevent postoperative venous thromboembolism after surgery for digestive tract cancer: Randomized trial.

PLoS ONE, 2023
Cancer and/or major surgery are two factors that predispose to post-operative thrombosis. The annual incidence of venous thromboembolic disease (VTED) in cancer patients was estimated at 0.5%-20%.
Chadli Dziri, Wafa Ben Hmida, Wejih Dougaz, Mehdi Khalfallah, Imen Samaali, Hichem Jerraya, Ibtissem Bouasker, Ramzi Nouira   +7 more
doaj   +1 more source

Admission thrombelastography does not guide dose adjustment of enoxaparin in trauma patients

Surgery Open Science, 2020
Background: Enoxaparin is used as chemoprophylaxis to reduce incidence of venous thromboembolism and its complications following trauma. Serum anti-Xa monitoring is used to assess efficacy but requires several doses to be administered. Thrombelastography
Hannah V. Hayes, Molly E. Droege, Craig J. Furnish, Michael D. Goodman, Neil E. Ernst, Christopher A. Droege   +5 more
doaj   +1 more source

The effects of enoxaparin on the liver in experimental pneumoperitoneum model [PDF]

Acta Cirúrgica Brasileira, 2016
PURPOSE: To investigate the potential protective effects of enoxaparin against the adverse events of carbon dioxide (CO2) pneumoperitoneum. METHODS: Thirty four rats were divided into three groups: Group 1 (sham) underwent insertion of Veress needle ...
Turgut Cavusoglu, Kemal Kismet, Namik Ozcan, Berkay Kucuk, Aziz Mutlu Barlas, Bahadir Osman Bozkirli, Pinar Celepli, Mehmet Senes, Serkan Bolat, Sema Hucumenoglu   +9 more
doaj   +2 more sources

Cell-Penetrating Peptide-Surface Modified Liposomes to Enhance the Intestinal Absorption of Enoxaparin [PDF]

Pharmaceutical Sciences, 2023
Background: Enoxaparin is low-molecular-weight heparin administered by subcutaneous/intravenous injection. The oral bioavailability of enoxaparin is restricted by its low absorption through the intestine.
Hessam Rostamian, Hadi Valizadeh, Mohammad Mahmoudian, Ziba Islambulchilar, Parvin Zakeri-Milani   +4 more
doaj   +1 more source

The Impact of Continuous Veno-Venous Hemodiafiltration on the Efficacy of Administration of Prophylactic Doses of Enoxaparin: A Prospective Observational Study

Pharmaceuticals, 2023
Background: Critically ill patients frequently require continuous renal replacement therapy (CRRT). During CRRT, particles up to 10 kDa in size, such as enoxaparin, may be removed. The aim of this study was to determine if patients receiving prophylactic
Aleksander Aszkiełowicz, Karol P. Steckiewicz, Michał Okrągły, Magdalena A. Wujtewicz, Radosław Owczuk   +4 more
doaj   +1 more source

Characterizing the delays in adequate thromboprophylaxis after TBI

Trauma Surgery & Acute Care Open, 2021
Background We sought to compare enoxaparin dosing for venous thromboembolism (VTE) prophylaxis in trauma patients with and without traumatic brain injury (TBI) to better understand the time and dose required to reach target anti-Xa levels. Our hypothesis
Eric J Ley, Navpreet K Dhillon, Yassar M Hashim, Naomi Berezin, Felix Yong, Geena Conde, Russell Mason   +6 more
doaj   +1 more source

Thromboprophylaxis with enoxaparin is associated with a lower death rate in patients hospitalized with SARS-CoV-2 infection. A cohort study

EClinicalMedicine, 2020
Background: Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection is associated with hypercoagulability caused by direct invasion of endothelial cells and/or proinflammatory cytokine release.
Filippo Albani, Lilia Sepe, Federica Fusina, Chiara Prezioso, Manuela Baronio, Federica Caminiti, Antonella Di Maio, Barbara Faggian, Maria Elena Franceschetti, Marco Massari, Marcello Salvaggio, Giuseppe Natalini   +11 more
doaj   +1 more source

Pharmacoequivalence of Enoxaparin and Contaminated Enoxaparin

Blood, 2008
Abstract Introduction: Earlier this year, heparin was found to be contaminated with a non-heparin sulfated polymer identified as oversulfated chondroitin sulfate (OSCS). The presence of this contaminant was associated with severe adverse reactions such as hypotension and anaphylaxis, leading to death in some patients.
Jacqueline Kuziej, Walter Jeske, Debra Hoppensteadt, Evangelos Litinas, Elizabeth McGeehan, Jawed Fareed, Richard H. Kennedy   +6 more
openaire   +1 more source

Critically ill patients with edema and ascites may experience subtherapeutic anti-factor Xa levels following abdominal subcutaneous enoxaparin treatment

SAGE Open Medical Case Reports, 2022
Enoxaparin is a low molecular weight heparin that is principally prescribed for the treatment and prevention of thromboembolic disorders. In clinical practice, the abdominal site for subcutaneous enoxaparin administration is most preferable because of ...
Vichapat Tharanon, Theerasuk Kawamatawong   +1 more
doaj   +1 more source