Results 101 to 110 of about 4,789 (198)
ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistance
Cell ReportsSummary: The mechanism underlying the role of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) in metabolic disease remains unsolved. Using a 2′3′-cyclic GMP-AMP (cGAMP)-hydrolysis-deficient mouse ( Enpp1 H362A ), we show that selective loss of
Songnan Wang +13 more
doaj +1 more source
Enpp1 enzyme replacement restores bone mass in murine model of Enpp1 associated osteoporosis
Bone Reports, 2020 Demetrios Braddock +9 more
openaire +2 more sources
Quantitative correlation of ENPP1 pathogenic variants with disease phenotype
BoneEctonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) codes for a type 2 transmembrane glycoprotein which hydrolyzes extracellular phosphoanhydrides into bio-active molecules that regulate, inter alia, ectopic mineralization, bone formation, vascular endothelial proliferation, and the innate immune response.
Ansh, Anenya Jai +8 more
openaire +2 more sources
ENPP1 gene, insulin resistance and related clinical outcomes
, 2007 Purpose of review Insulin resitance plays a significant role in both morbidity and mortality of the general population. Understanding the molecular mechanisms of insulin resistance would help the identification of at-risk individuals in the ...
Sabrina Prudente +3 more
core +1 more source
Arterial Calcification Is Driven by RAGE in <i>Enpp1</i>–/– Mice
, 2010 <i>Background/Aims:</i> Ectopic osteochondral differentiation, driven by ENPP1-catalyzed generation of the chondrogenesis and calcification inhibitor inorganic pyrophosphate (PP<sub>i</sub>), promotes generalized arterial ...
Denise L. Cecil, Robert A. Terkeltaub
core +1 more source
Frontiers in EndocrinologyBackgroundRecently, in our clinical work, we discovered a case of abnormal bone metabolism in children resulting from an inactivated mutation of the ENPP1 gene.
Siyi Lu +4 more
doaj +1 more source
Nature CommunicationsDespite the STING-type-I interferon pathway playing a key role in effective anti-tumor immunity, the therapeutic benefit of direct STING agonists appears limited.
Congying Pu +16 more
doaj +1 more source
Calcification of Bruch’s membrane and RPE-associated functional changes in the ENPP1 transgenic mice
Purpose : In the absence of pathology, calcification is restricted to bones and teeth. Calcium and phosphate are strictly regulated to avoid ectopic calcification. However, in diseases like age-related macular degeneration (AMD), pseudoxanthoma elasticum
Cunningham, Fiona +11 more
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Inhibition of abnormal calcification by augmented ENPP1 via Nrf2 [PDF]
研究成果の概要（和文）： 本研究では、Nrf2活性化剤がENPP1発現を増強し、細胞外ピロリン酸濃度を上昇させることで石灰化を抑制することを明らかにした。バイオインフォマティクス解析とChIP-PCR実験により、Nrf2がENPP1プロモーター領域に結合して転写を促進することを確認した。また、培養実験と異所性石灰化モデルマウス（ttwマウス）を用いた実験で、Nrf2活性化が石灰化を有意に抑制することを実証した。これらの結果は、Nrf2活性化による異所性石灰化の予防が新規治療戦略となる可能性を示している ...
30333826 +4 more
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