Genes Associated With Fracture Risk in Thoroughbred Horses Have Novel Roles in Osteogenesis
Animal Genetics, Volume 57, Issue 4, August 2026.ABSTRACT Bone fractures in Thoroughbred racehorses are a major welfare problem. Genetic factors contribute to fracture risk. Cell models have previously identified 112 differentially expressed genes in bone‐forming osteoblasts derived from horses at high and low genetic risk of fracture. However, 42 of these genes have no published role in bone.
Amy C. Ross +5 more
wiley +1 more source
The prevalence of ENPP1 deficiency and the preclinical efficacy of ENPP1 biologic therapy in OPLL.
Abstract Ossification of the Posterior Longitudinal Ligament (OPLL) and Diffuse Idiopathic Skeletal Hyperostosis (DISH) are disorders in which patients suffer from pain and stiffness due to progressive spinal fractures and enthesospathy.
Demetrios Braddock +21 more
openaire +1 more source
Emergence of osteocytic markers in the calcified aorta from the Enpp1−/− mouse in vivo.
, 2013 Medial aortic calcification was detected by alizarin red staining (arrows) in (a) Enpp1−/− tissue compared to (b) Enpp1+/+ control. Increased protein expression of (c, d) E11 and (g, h) Sclerostin was observed in the calcified media of Enpp1−/− aortic ...
Neil Charles Wallace Mackenzie (332889) +4 more
core +1 more source
Frontiers in EndocrinologyBackgroundEctonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) plays a key role in mineralization processes, and mutations in this gene are associated with various severe diseases.
Wanhong Wu +6 more
doaj +1 more source
Association of K121Q polymorphism ENPP1 gene with T2DM in persons of different sexes in Ukrainian population [PDF]
, 2016 Nowadays, the biological role of Ectonucleotide Pyrophosphatase Phosphodiesterase 1 (ENPP1) is not fully understood, but there are two groups of evidences concerning the ENPP1 significance in pathogenesis of some pathological processes and diseases.
Marchenko, Iryna Vasylivna +2 more
core
Disease Models & Mechanisms, 2014 In recent years it has become clear that, mechanistically, biomineralization is a process that has to be actively inhibited as a default state. This inhibition must be released in a rigidly controlled manner in order for mineralization to occur in ...
Alexander Apschner +4 more
doaj +1 more source
Role of GALNT2 in the modulation of ENPP1 expression, and insulin signaling and action GALNT2: A novel modulator of insulin signaling [PDF]
, 2013 Ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) inhibits insulin signaling and action. Understanding the mechanisms underlying ENPP1 expression may help unravel molecular mechanisms of insulin resistance.
Antonella Marucci +13 more
core +1 more source
Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors
, 2022 In an effort to discover novel scaffolds of non-nucleotide-derived Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors to stimulate the Stimulator of Interferon Genes (STING) pathway, we designed and synthesised pyrrolopyrimidine and ...
Hyo Jae Yoon (1630678) +14 more
core +1 more source
Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions
Scientific Reports, 2017 Control of phosphate metabolism is crucial to regulate aging in mammals. Klotho is a well-known anti-aging factor that regulates phosphate metabolism: mice mutant or deficient in Klotho exhibit phenotypes resembling human aging.
Ryuichi Watanabe +14 more
doaj +1 more source
HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer
, 2023 The tumor-immune microenvironment (TIME) is a critical determinant of therapeutic response. However, the mechanisms regulating its modulation are not fully understood. HER2A16, an oncogenic splice variant of the HER2, has been implicated in breast cancer
Attalla, Sherif Samer +35 more
core +1 more source