Results 91 to 100 of about 4,789 (198)

MicroCT analysis of trabecular bone in male wild-type and Enpp1^−/− mice.

, 2013
6 week femur (WT and Enpp1−/− n = 7) and tibia (WT n = 6, Enpp1−/− n = 7) and 22 week femur (WT and Enpp1−/− n = 9) and tibia (WT and Enpp1−/− n = 9) were tested.
Rob van 't Hof (332893), Elspeth M. Milne (332891), Vicky Elisabeth MacRae (332898), Neil Charles Wallace Mackenzie (332889), Dongxing Zhu (332890), Darryl Leigh Quarles (332895), Aline Martin (308465), Colin Farquharson (323916), José Luis Millán (3966677)   +8 more
core   +1 more source

Naturally occurring quercetin and myricetin as potent inhibitors for human ectonucleotide pyrophosphatase/phosphodiesterase 1

Scientific Reports
Ecto-nucleotide pyrophosphatases/phosphodiesterases 1 (ENPP1) is a key enzyme in purinergic signaling pathways responsible for cell-to-cell communications and regulation of several fundamental pathophysiological processes.
Peeradon Duangiad, Bodee Nutho, Thawatchai Chaijarasphong, Noppawan Phumala Morales, Thunyarat Pongtharangkul, Itaru Hamachi, Akio Ojida, Jirarut Wongkongkatep   +7 more
doaj   +1 more source

Uric Acid Impairs Insulin Signaling by Promoting Enpp1 Binding to Insulin Receptor in Human Umbilical Vein Endothelial Cells

Frontiers in Endocrinology, 2018
High levels of uric acid (UA) are associated with type-2 diabetes and cardiovascular disease. Recent pieces of evidence attributed to UA a causative role in the appearance of diabetes and vascular damage.
Eliezer J. Tassone, Antonio Cimellaro, Maria Perticone, Marta L. Hribal, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti, Francesco Perticone   +7 more
doaj   +1 more source

Clinical and Biochemical Phenotypes in a Family With ENPP1 Mutations

Journal of Bone and Mineral Research, 2019
ABSTRACT Inactivating mutations of the ENPP1 gene are associated with generalized arterial calcification of infancy (GACI) and less often autosomal-recessive hypophosphatemic rickets type 2 (ARHR2). We aimed to investigate the spectrum of phenotypes in a family with monoallelic and biallelic mutations of ENPP1 after identification ...
Anupam Kotwal, Alejandro Ferrer, Rajiv Kumar, Ravinder J Singh, Vishakantha Murthy, Laura Schultz-Rogers, Michael Zimmermann, Brendan Lanpher, Kristin Zimmerman, Paul R Stabach, Eric Klee, Demetrios T Braddock, Robert A Wermers   +12 more
openaire   +3 more sources

MicroCT analysis of cortical bone in male wild-type and Enpp1^−/− mice.

, 2013
6 week femur (WT n = 7, Enpp1−/− n = 6) and tibia (WT n = 6, Enpp1−/− n = 7) and 22 week femur (WT and Enpp1−/− n = 9) and tibia (WT n = 8, Enpp1−/− n = 9) were tested.
Rob van 't Hof (332893), Elspeth M. Milne (332891), Vicky Elisabeth MacRae (332898), Neil Charles Wallace Mackenzie (332889), Dongxing Zhu (332890), Darryl Leigh Quarles (332895), Aline Martin (308465), Colin Farquharson (323916), José Luis Millán (3966677)   +8 more
core   +1 more source

Could the ENPP1 p.D85H Mutation be Associated with Hypophosphatemic Rickets?

Bezmiâlem Science, 2018
Objective:A 35-year-old Turkish male patient was referred to us with a year-long history of joint paint and congenital hearing loss. Family history revealed more family members with hearing loss without paraneoplastic syndrome.
Ender COŞKUNPINAR, Sakin TEKİN, Şükrü PALANDUZ, Hakan AVCI, Kıvanç CEFLE, N. Ozan TİRYAKİOĞLU, Ayşe KUBAT ÜZÜM, Refik TANAKOL, İlhan SATMAN   +8 more
doaj   +1 more source

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1

Nature Communications, 2018
Ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) is a type II transmembrane glycoprotein that hydrolyzes both ATP and cGAMP. Here the authors present the crystal structures of the extracellular domain of mouse ENPP1 in complex with 3′3′-cGAMP ...
Kazuki Kato, Hiroshi Nishimasu, Daisuke Oikawa, Seiichi Hirano, Hisato Hirano, Go Kasuya, Ryuichiro Ishitani, Fuminori Tokunaga, Osamu Nureki   +8 more
doaj   +1 more source

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes in northern Chinese

, 2011
The K121Q polymorphism of the ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to insulin resistance, type 2 diabetes, and obesity, and conflicting results were observed in various populations. The purpose
Jin, Feng, Wang, Li, Tang, Lei, Sun, Liang, Yang, Ze, Shi, XH (reprint author), Beijing Hosp, Key Lab Geriatr, Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China., Sun, Junfeng, Shi, Xiaohong   +7 more
core  

Improving the Pharmacodynamics and In Vivo Activity of ENPP1‐Fc Through Protein and Glycosylation Engineering

, 2020
Enzyme replacement with ectonucleotide pyrophosphatase phospodiesterase‐1 (ENPP1) eliminates mortality in a murine model of the lethal calcification disorder generalized arterial calcification of infancy. We used protein engineering, glycan optimization,
Paul R. Stabach, Christian Agatemor, Kevin J. Yarema, Yarema, Kevin J., Stabach, Paul R., Braddock, Demetrios T., Christopher T. Saeui, De La Cruz, Enrique M., Dillon Kavanagh, Aaron Adame, Cao, Wenxiang, Agatemor, Christian, Shawn Gray, Demetrios T. Braddock, Saeui, Christopher T., Gray, Shawn, Kristin Zimmerman, Adame, Aaron, Wenxiang Cao, Enrique M. De La Cruz, Zimmerman, Kristin, Kavanagh, Dillon   +21 more
core   +1 more source

Synovial Membrane Is a Major Producer of Extracellular Inorganic Pyrophosphate in Response to Hypoxia

Pharmaceuticals
Calcium pyrophosphate dehydrate (CPPD) crystals are found in the synovial fluid of patients with articular chondrocalcinosis or sometimes with osteoarthritis.
Émilie Velot, Sylvie Sébillaud, Arnaud Bianchi   +2 more
doaj   +1 more source