Results 71 to 80 of about 1,838,152 (282)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Weakly enriched higher categories [PDF]
, 2013 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mathematics, 2013.Cataloged from PDF version of thesis.Includes bibliographical references (pages 189-190).The goal of this thesis is to begin to lay the foundations for a theory of ...
Haugseng, Rune
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
On lax protomodularity for Ord-enriched categories [PDF]
, 2023 Our main focus concerns a possible lax version of the algebraic property of protomodularity for Ord-enriched categories. Having in mind the role of comma objects in the enriched context, we consider some of the characteristic properties of ...
Rodelo D., Montoli A., Clementino M. M.
core +1 more source
Prediction of HIV-1 virus-host protein interactions using virus and host sequence motifs
BMC Medical Genomics, 2009 Background Host protein-protein interaction networks are altered by invading virus proteins, which create new interactions, and modify or destroy others.
Tozeren Aydin +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Comparative transcriptome analysis of flower heterosis in two soybean F1 hybrids by RNA-seq. [PDF]
PLoS ONE, 2017 Heterosis has been widely exploited as an approach to enhance crop traits during breeding. However, its underlying molecular genetic mechanisms remain unclear. Recent advances in RNA sequencing technology (RNA-seq) have provided an opportunity to conduct
Chunbao Zhang +11 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Mixed Relations as Enriched Semiringal Categories
J. Univers. Comput. Sci., 2000 JUCS - Journal of Universal Computer Science Volume Nr.
Grosu,Radu +2 more
openaire +2 more sources