Results 101 to 110 of about 1,044,040 (304)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The limits of human predictions of recidivism. [PDF]

, 2020
Dressel and Farid recently found that laypeople were as accurate as statistical algorithms in predicting whether a defendant would reoffend, casting doubt on the value of risk assessment tools in the criminal justice system.
Goel, Sharad, Jung, Jongbin, Lin, Zhiyuan Jerry, Skeem, Jennifer   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Meanings and Expressions of Caring Among Nurses in Clinical Workplace: a Literature Review [PDF]

, 2013
Background: Research shows that nurse retention is high as a result of a stressful work environment coupled with inadequate support in clinical workplace.
Hatthakit, U. (Urai), Mayasari, P. (Putri), Thiangchanya, P. (Pratyanan)   +2 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The enriched environment: Making multiple connections

Academic Leadership: The Online Journal, 2010
One only has to reflect on what it took them to learn and master an activity and a few things may cometo mind. Perhaps the activity was learning Cardiopulmonary Resuscitation (CPR), and if so, theprocess for learning the task, really learning it, involved making many associations with the task.
Timothy Clapper, null null, null null, null null   +3 more
openaire   +2 more sources

Expanding sensor networks to automate knowledge acquisition [PDF]

, 2011
The availability of accurate, low-cost sensors to scientists has resulted in widespread deployment in a variety of sporting and health environments. The sensor data output is often in a raw, proprietary or unstructured format.
Conroy, Kenneth, May, Gregory, Roantree, Mark, Warrington, Giles   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Environmental stimuli shape microglial plasticity in glioma

eLife, 2017
In glioma, microglia and infiltrating macrophages are exposed to factors that force them to produce cytokines and chemokines, which contribute to tumor growth and to maintaining a pro-tumorigenic, immunosuppressed microenvironment.
Stefano Garofalo, Alessandra Porzia, Fabrizio Mainiero, Silvia Di Angelantonio, Barbara Cortese, Bernadette Basilico, Francesca Pagani, Giorgio Cignitti, Giuseppina Chece, Roberta Maggio, Marie-Eve Tremblay, Julie Savage, Kanchan Bisht, Vincenzo Esposito, Giovanni Bernardini, Thomas Seyfried, Jakub Mieczkowski, Karolina Stepniak, Bozena Kaminska, Angela Santoni, Cristina Limatola   +20 more
doaj   +1 more source

Incremental Consistency Checking in Delta-oriented UML-Models for Automation Systems

, 2016
Automation systems exist in many variants and may evolve over time in order to deal with different environment contexts or to fulfill changing customer requirements.
Kowal, Matthias, Schaefer, Ina
core   +1 more source