Results 81 to 90 of about 1,044,040 (304)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A study on multi-enriched housing environment in blue foxes [PDF]

, 2015
201
Eskeli, Pekka, Korhonen, Hannu T.
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Evidence of Springwater Acidification in the Vosges Mountains (North-East of France): Influence of Bedrock Buffering Capacity [PDF]

, 1999
Investigations on springwater acidity were carried out in the Vosges mountains (north-eastern France). Acid or poorly buffered spring and streamwaters were detected in the same area.
Dambrine, Etienne, Février, Clotilde, Party, Jean-Paul, Probst, Anne, Stussi, J.M., Thomas, Anne-Laure   +5 more
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

MRI Evaluation of Axonal Remodeling After Combination Treatment With Xiaoshuan Enteric-Coated Capsule and Enriched Environment in Rats After Ischemic Stroke

Frontiers in Physiology, 2019
Xiaoshuan enteric-coated capsule (XSEC) is a compound Chinese medicine widely used for the treatment of ischemic stroke. Enriched environment (EE) is a rehabilitative intervention designed to facilitate physical, cognitive, and social activity after ...
Man-Zhong Li, Man-Zhong Li, Yu Zhan, Yu Zhan, Le Yang, Le Yang, Xue-Feng Feng, Xue-Feng Feng, Hai-Yan Zou, Hai-Yan Zou, Jian-Feng Lei, Ting Zhao, Ting Zhao, Lei Wang, Lei Wang, Hui Zhao, Hui Zhao   +16 more
doaj   +1 more source

Enriched Environment and White Matter in Aging Brain [PDF]

The Anatomical Record, 2012
AbstractNormal aging is commonly associated with decreased cognitive functions, which could be conspicuously alleviated by enriched environment (EE) with physical, social, and sensory stimuli, suggesting that aging brain still has intriguing plasticity.
Shu, Yang, Wei, Lu, De-Shan, Zhou, Yong, Tang   +3 more
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Environmental Enrichment Prevents Transcriptional Disturbances Induced by Alpha-Synuclein Overexpression

Frontiers in Cellular Neuroscience, 2018
Onset and progression of neurodegenerative disorders, including synucleinopathies such as Parkinson's disease, have been associated with various environmental factors.
Zinah Wassouf, Thomas Hentrich, Sebastian Samer, Sebastian Samer, Carola Rotermund, Philipp J. Kahle, Philipp J. Kahle, Ingrid Ehrlich, Ingrid Ehrlich, Ingrid Ehrlich, Olaf Riess, Nicolas Casadei, Julia M. Schulze-Hentrich   +12 more
doaj   +1 more source

A task-centred approach to evaluating a mobile learning environment for pedagogical soundness [PDF]

, 2004
The focus of this paper is how to evaluate the pedagogical soundness of a mobile learning environment in which many users (both teachers and learners) may not have previously encountered mobile technology, so may be uncertain how best to deploy it to ...
Taylor, Josie
core