Results 141 to 150 of about 1,044,040 (304)

The MAJORANA DEMONSTRATOR: A Search for Neutrinoless Double-beta Decay of Germanium-76

, 2011
The observation of neutrinoless double-beta decay would determine whether the neutrino is a Majorana particle and provide information on the absolute scale of neutrino mass.
Aguayo, E., Avignone III, F. T., Back, H. O., Barabash, A. S., Bergevin, M., Bertrand, F. E., Boswell, M., Brudanin, V., Busch, M., Chan, Y-D., Christofferson, C. D., Collar, J. I., Combs, D. C., Cooper, R. J., Detwiler, J. A., Doe, P. J., Efremenko, Yu., Egorov, V., Ejiri, H., Elliott, S. R., Esterline, J., Fast, J. E., Fields, N., Finnerty, P., Fraenkle, F. M., Gehman, V. M., Giovanetti, G. K., Green, M. P., Guiseppe, V. E., Gusey, K., Hallin, A. L., Hazama, R., Henning, R., Hime, A., Hoppe, E. W., Horton, M., Howard, S., Howe, M. A., Johnson, R. A., Keeter, K. J., Keillor, M. E., Keller, C., Kephart, J. D., Kidd, M. F., Knecht, A., Kochetov, O., Konovalov, S. I., Kouzes, R. T., LaFerriere, B., LaRoque, B. H., Leon, J., Leviner, L. E., Loach, J. C., MacMullin, S., MAJORANA Collaboration, Marino, M. G., Martin, R. D., Mei, D. -M., Merriman, J., Miller, M. L., Mizouni, L., Nomachi, M., Orrell, J. L., Overman, N., Perumpilly, G., Phillips II, D. G., Poon, A. W. P., Prior, G., Radford, D. C., Rielage, K., Robertson, R. G. H., Ronquest, M. C., Schubert, A. G., Shima, T., Shirchenko, M., Snavely, K. J., Sobolev, V., Steele, D., Strain, J., Thomas, K., Timkin, V., Tornow, W., Vanyushin, I., Varner, R. L., Vetter, K., Vorren, K., Wilkerson, J. F., Wolfe, B. A., Yakushev, E., Young, A. R., Yu, C. ?H., Yumatov, V., Zhan, C.   +92 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Soil domestication by rice cultivation results in plant-soil feedback through shifts in soil microbiota. [PDF]

, 2019
BackgroundSoils are a key component of agricultural productivity, and soil microbiota determine the availability of many essential plant nutrients.
Edwards, Joseph, Kilmer, John, Liechty, Zachary, Nguyen, Bao, Ni, Jiadong, Phillips, Gregory, Santos-Medellín, Christian, Sundaresan, Venkatesan, Veliz, Esteban   +8 more
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

AM‐11: Enriched environments [PDF]

Alzheimer's & Dementia, 2007
openaire   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source