Results 61 to 70 of about 1,026,955 (282)

Environmental Enrichment Reverses Maternal Sleep Deprivation-Induced Anxiety-Like Behavior and Cognitive Impairment in CD-1 Mice

Frontiers in Behavioral Neuroscience, 2022
Preclinical studies have clearly indicated that offspring of mothers who suffered sleep deprivation during pregnancy exhibit anxiety, depression-like behaviors, and cognitive deficits.
Yue-Ming Zhang, Yun-Zhou Cheng, Ya-Tao Wang, Ru-Meng Wei, Yi-Jun Ge, Xiao-Yi Kong, Xue-Yan Li   +6 more
doaj   +1 more source

Recovery from population III supernova explosions and the onset of second generation star formation

, 2014
We use cosmological simulations to assess how the explosion of the first stars in supernovae (SNe) influences early cosmic history. Specifically, we investigate the impact by SNe on the host systems for Population~III (Pop~III) star formation and explore
Bromm, Volker, Jeon, Myoungwon, Milosavljevic, Milos, Pawlik, Andreas H.   +3 more
core   +1 more source

BIM semantic-enrichment for built heritage representation [PDF]

, 2018
In the built heritage context, BIM has shown difficulties in representing and managing the large and complex knowledge related to non-geometrical aspects of the heritage.
Acierno, Marta, Cursi, Stefano, Simeone, Davide   +2 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A deep Chandra observation of the poor cluster AWM4 - II. The role of the radio jets in enriching the intra-cluster medium

, 2010
We use a Chandra observation of the poor cluster AWM4 to map the temperature and abundance of the intra-cluster medium, so as to examine the influence of the central radio galaxy on its environment.
Ascasibar, Bildfell, Brüggen, Burns, Böhringer, Cappellaro, Ciotti, David, De Grandi, Denicoló, Edge, Ewan O’Sullivan, Gastaldello, Giacintucci, Gitti, Grevesse, Hicks, Jan M. Vrtilek, Kaastra, Kalberla, Kirkpatrick, Koranyi, Kuntz, Laurence P. David, Markevitch, Mazzotta, McNamara, Mittal, Nomoto, Nulsen, O’Dea, O’Sullivan, O’Sullivan, O’Sullivan, Peterson, Pipino, Rasia, Rasmussen, Rasmussen, Rebusco, Rebusco, Roediger, Salomé, Sanders, Schombert, Simionescu, Simionescu, Simionescu, Simona Giacintucci, Snowden, Somak Raychaudhury, Vikhlinin, Weisskopf, Werner, Xiang   +54 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Enriched environment attenuates hippocampal theta and gamma rhythms dysfunction in chronic cerebral hypoperfusion via improving imbalanced neural afferent levels

Frontiers in Cellular Neuroscience, 2023
Chronic cerebral hypoperfusion (CCH) is increasingly recognized as a common cognitive impairment-causing mechanism. However, no clinically effective drugs to treat cognitive impairment due to CCH have been identified.
Jiaxin Zheng, Sisi Peng, Lingling Cui, Xi Liu, Tian Li, Zhenyu Zhao, Yaqing Li, Yuan Hu, Miao Zhang, Linling Xu, JunJian Zhang   +10 more
doaj   +1 more source

DiVM: Model Checking with LLVM and Graph Memory

, 2017
In this paper, we introduce the concept of a virtual machine with graph-organised memory as a versatile backend for both explicit-state and abstraction-driven verification of software. Our virtual machine uses the LLVM IR as its instruction set, enriched
Barnat, Jiří, Ročkai, Petr, černá, Ivana, Štill, Vladimír   +3 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Impact of Pharmacological and Non-Pharmacological Modulators on Dendritic Spines Structure and Functions in Brain

Cells, 2021
Dendritic spines are small, thin, hair-like protrusions found on the dendritic processes of neurons. They serve as independent compartments providing large amplitudes of Ca2+ signals to achieve synaptic plasticity, provide sites for newer synapses ...
Arehally M. Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Tousif Ahmed Hediyal, Praveen Raj, Annan Gopinath Rathipriya, M. Walid Qoronfleh, Musthafa Mohamed Essa, Saravana Babu Chidambaram   +8 more
doaj   +1 more source