Results 131 to 140 of about 1,292,580 (305)
The potential for microchip-automated technology to improve enrichment practices
, 2009 The greatest limitation involved with providing enrichment and evaluating its effects on captive mammals is a lack of available staff time [Hoy et al., 2009].
Peter J. Murray +5 more
core +1 more source
Shiyou shiyan dizhiFracture systems significantly influence the storage capacity and seepage characteristics of oil and gas reservoirs, and accurately identifying fracture fluid types is crucial for reservoir evaluation and development.
Yuwei LIU +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Peptidomics of salivary histatins: enrichment strategy and de-novo sequencing
, 2016 Peptidomics of salivary histatins: enrichment strategy and de-novo ...
V Marzano +7 more
core
Enrichment-isolation, cortex length and the rank order effect
, 2023 In a previous paper we have proposed a developmental theory to account for the neurological changes which result from differentially rearing animals in either enrichment or isolation.
Robert Cummins (13065627) +1 more
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
ligand-discovery/protein-set-enrichment-analysis: Publication release
Protein set enrichment ...
Miquel Duran-Frigola
core +1 more source