Results 111 to 120 of about 1,344,829 (308)
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Community enrichment program: developing digital learning in rural aged care [PDF]
, 2015 Project Overview The ‘Community Enrichment Program’ enabled technology training for selected aged care volunteers in Stanthorpe, Queensland, so that they may assist frail or otherwise debilitated aged care residents to use computer tablets for ...
McDonald, Lisa, Arden, Catherine
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Work-family conflict and enrichment: Direct and indirect effects towards mental health outcomes [PDF]
, 2010 There have been calls in the work-family literature for greater attention to moderation effects. Further, the established work-family conflict approach has expanded to include work-family enrichment.
Lewis, Johanna Brooke
core
The potential for microchip-automated technology to improve enrichment practices
, 2009 The greatest limitation involved with providing enrichment and evaluating its effects on captive mammals is a lack of available staff time [Hoy et al., 2009].
Peter J. Murray +5 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Improving the speediness of complex sample analysis has attracted much research interest in analytical science. In this work, an enrichment-sensing all-in-one strategy was presented for rapid surface-enhanced Raman spectroscopy (SERS) analysis of purine ...
Gongke Li (1496560) +2 more
core +1 more source
Shiyou shiyan dizhiChina possesses abundant shale oil resources, but exploration and development have progressed slowly due to the strong heterogeneity and complex fracture development in continental shale reservoirs.
Peng CHEN +7 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source