Results 91 to 100 of about 1,926,101 (297)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Reflections and implementation strategies for constructing a standard system for deep coalbed methane exploration and exploitation

Meitian dizhi yu kantan
ObjectiveDeep coalbed methane (CBM; burial depths: > 1500 m) in China holds considerable resource potential. As a strategic clean energy, deep CBM is exhibiting increasingly high value of exploitation and utilization.
Xinjun CHEN, Zengqin LIU, Baojian SHEN, Shihu ZHAO, Jiaqi ZHANG, Jincheng YE   +5 more
doaj   +1 more source

Random-set methods identify distinct aspects of the enrichment signal in gene-set analysis

, 2007
A prespecified set of genes may be enriched, to varying degrees, for genes that have altered expression levels relative to two or more states of a cell.
Ahlquist, Paul, Boon, Johan A. den, Newton, Michael A., Quintana, Fernando A., Sengupta, Srikumar   +4 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

PENYUSUNAN BUKU PENGAYAAN PINTU GERBANG DIMENSI EKSPLANASI KELAS V DAN VI SD BAHASA INDONESIA MATERI TEKS EKSPLANASI SESUAI STANDAR PENERBIT PT INTAN PARIWARA [PDF]

Enrichment book development is an important process in the context of modern education. Enrichment books are designed to provide additional material or activities that can enrich students' understanding beyond the main curriculum.
Pratiwi, Nandha Satya
core  

Enrichment Procedures for Soft Clusters: A Statistical Test and its Applications [PDF]

, 2010
Clusters, typically mined by modeling locality of attribute spaces, are often evaluated for their ability to demonstrate ‘enrichment’ of categorical features.
Phillips, Rhonda D., Ramakrishnan, Naren, Watson, Layne T., Wynne, Randolph H.   +3 more
core   +1 more source

Metal Enrichment in the Reionization Epoch

, 2015
The presence of elements heavier than helium ("metals") is of fundamental importance for a large number of astrophysical processes occurring in planet, star and galaxy formation; it also affects cosmic structure formation and evolution in several ways ...
A. Ferrara, A. H. Pawlik, A. Heger, A. Pallottini, A. Pallottini, B. Ciardi, B. D. Oppenheimer, B. D. Oppenheimer, B. D. Oppenheimer, B. D. Oppenheimer, B. D. Smith, B. K. Gibson, C. Evoli, C. Scannapieco, C. W. Churchill, D. Schaerer, D. Schaerer, E. E. Salpeter, E. Giallongo, E. Scannapieco, E. Sobacchi, E. Sobacchi, E. Tescari, F. Iocco, F. Y. Wang, G. C. Rudie, G. C. Rudie, G. D. Becker, G. D. Becker, G. D. Becker, H.-W. Chen, J. H. Wise, J. M. Shull, L. C. Keating, L. Gao, L. Tornatore, M. Asplund, M. Bruscoli, M. Mapelli, M. McQuinn, P. Barai, P. Madau, P. R. Shapiro, Planck Collaboration, R. Cen, R. Cen, R. Salvaterra, R. Salvaterra, R. Schneider, R. Schneider, S. Borthakur, S. E. Woosley, S. Gallerani, S. Naoz, S. P. Oh, S. R. Furlanetto, S. Salvadori, S. Salvadori, T. H. Greif, T. Hosokawa, T. Totani, U. Maio, V. D’Odorico, V. Springel   +63 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

V453 Oph: a s-process enriched, but carbon-deficient RV Tauri star of low intrinsic metallicity

, 2005
This paper reports the detection of a heavy element enriched RV Tauri variable with an abundance pattern that differs significantly from a standard s-process enriched object: V453 Oph.
Alcock, Aoki, Aoki, Biémont, Bloecker, Boesgaard, Burris, Cowan, De Ruyter, Evans, François, Gallino, Gehrz, Giridhar, Giridhar, Goldsmith, Gonzalez, Goriely, Gratton, Gratton, H. Van Winckel, Hibbert, Hibbert, Josafatsson, Jura, Krełowski, Kupka, L. Siess, Lambert, Lawler, Lawler, M. Reyniers, Maas, Mathis, McClure, P. Deroo, Palmeri, Preston, Queloz, Reyniers, S. Goriely, Simmerer, Sneden, Thévenin, Tsujimoto, Van Eck, Van Winckel, Van Winckel, Van Winckel, Van Winckel, Van Winckel, Wallerstein, Wallerstein, Waters   +53 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source