Results 71 to 80 of about 1,292,580 (305)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Market Power in Uranium Enrichment [PDF]
Four firms dominate the international uranium enrichment market. Two reasons for this industrial concentration are (1) enrichment capacity can be used to make nuclear weapons, and hence its spread has been controlled through many mechanisms, including ...
Geoffrey Rothwell
core
The student experience of online mathematics enrichment
, 2000 Following concerns about the falling number of mathematics majors at University level, consideration has being given in a number of countries to enhancing provision for those school pupils who show the potential to study mathematics at University ...
Simons, Helen, Jones, Keith
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Bi-directional gene set enrichment and canonical correlation analysis identify key diet-sensitive pathways and biomarkers of metabolic syndrome. [PDF]
, 2010 peer-reviewedBackground Currently, a number of bioinformatics methods are available to generate appropriate lists of genes from a microarray experiment.
Morine Melissa J +23 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Plant responses to long-term "in situ" CO₂ enrichment and soil warming at treeline in the Swiss Alps [PDF]
, 2010 In situ studies lasting several years are essential for predicting how plant growth and ecosystem function will change under rising levels of atmospheric CO₂ and the associated changes in climate. High-latitude and high-elevation ecosystems are predicted
Dawes, Melissa Autumn
core +1 more source
Journal of Natural Gas Geoscience, 2017 Shale gas in Upper Ordovician Wufeng Formation–Lower Silurian Longmaxi Formation in the Sichuan Basin is one of the key strata being explored and developed in China, where shale gas reservoirs have been found in Fuling, Weiyuan, Changning and Zhaotong ...
Zhiliang He +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source