Results 61 to 70 of about 1,926,101 (297)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Discussion on the uniformity of shale oil and gas in China

Shiyou shiyan dizhi
Shale oil and gas are important strategic resources in China's energy sector, existing in shale formations with self-generation and self-storage characteristics.
Xusheng GUO, Baojian SHEN, Zhiming LI, Chengxiang WAN, Chuxiong LI, Qianwen LI   +5 more
doaj   +1 more source

Numerical Simulation on Hydrofracture Propagation in Fractured-Vuggy Unconventional Reservoirs

Geofluids, 2022
The unconventional reservoirs such as carbonate formation develops complex and diverse storage space structures, and it is composed of large-scale cavity, dissolved vug, and fractures. The carbonate reservoir is highly heterogeneous.
Tingxue Jiang, Haitao Wang, Xiaobing Bian, Daobing Wang, Jun Zhou, Bo Yu   +5 more
doaj   +1 more source

State transitions as morphisms for complete lattices [PDF]

, 1999
We enlarge the hom-sets of categories of complete lattices by introducing `state transitions' as generalized morphisms. The obtained category will then be compared with a functorial quantaloidal enrichment and a contextual quantaloidal enrichment that ...
Coecke, Bob, Stubbe, Isar
core   +3 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Regulation mechanisms of material transfer within continental shale on reservoir properties: a case study of shale from upper submember of fourth member of Paleogene Shahejie Formation, Niuzhuang Subsag, Bohai Bay Basin

Shiyou shiyan dizhi
Continental shale oil and gas are important areas for increasing oil and gas reserves and production in China. However, traditional macroscopic-to-core scale studies are insufficient to reveal the relationship between material migration within laminae ...
Jianbin TENG, Xiaoyu HAN, Pengfei ZHANG, Bo LI, Junliang LI, Zhuowei MIAO, Shun ZHANG, Lipeng ZHU   +7 more
doaj   +1 more source

Principal component gene set enrichment (PCGSE) [PDF]

, 2014
Motivation: Although principal component analysis (PCA) is widely used for the dimensional reduction of biomedical data, interpretation of PCA results remains daunting.
Frost, H. Robert, Li, Zhigang, Moore, Jason H.   +2 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source